2019冠状病毒病后嗅觉丧失和大脑连通性:一年的结构随访。

IF 3 4区 医学 Q2 NEUROSCIENCES Neural Plasticity Pub Date : 2023-01-01 DOI:10.1155/2023/6496539
Fabrizio Esposito, Mario Cirillo, Rosa De Micco, Giuseppina Caiazzo, Mattia Siciliano, Andrea G Russo, Caterina Monari, Nicola Coppola, Gioacchino Tedeschi, Alessandro Tessitore
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引用次数: 22

摘要

先前有报道称,在27名最近感染sars - COV- 2 (COV+)的受试者中,初级嗅觉皮层与主要次级嗅觉区域的结构连通性在内侧眶额皮质中相对增加,其中23/27临床证实嗅觉丧失,而对照组(COV-)正常的受试者中有18名以前未感染。为了补充这一发现,本文报告了对18/27名COV+受试者(10名男性,平均年龄±SD: 38.7±8.1岁)和10/18名COV-受试者(5名男性,平均年龄±SD: 33.1±3.6岁)收集的随访数据集进行相同的高角分辨率扩散MRI分析的结果,这些受试者在1年后重复了嗅觉功能评估和MRI检查。通过比较新衍生的亚组,我们观察到,尽管10/18 COV+受试者在感染SARS-CoV-2约1年后仍发现低呼吸,但随访时内侧眶额叶皮层结构连通性指数的增加并不显著。我们得出的结论是,至少在某些情况下,嗅觉皮层与内侧眶额皮质的相对超连通性可能是一种急性或可逆的现象,与最近的SARS-CoV-2感染相关的嗅觉丧失有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Olfactory Loss and Brain Connectivity after COVID-19: Structural Follow-Up at One Year.

The structural connectivity from the primary olfactory cortex to the main secondary olfactory areas was previously reported as relatively increased in the medial orbitofrontal cortex in a cohort of 27 recently SARS-CoV-2-infected (COV+) subjects, of which 23/27 had clinically confirmed olfactory loss, compared to 18 control (COV-) normosmic subjects, who were not previously infected. To complement this finding, here we report the outcome of an identical high angular resolution diffusion MRI analysis on follow-up data sets collected in 18/27 COV+ subjects (10 males, mean age ± SD: 38.7 ± 8.1 years) and 10/18 COV- subjects (5 males, mean age ± SD: 33.1 ± 3.6 years) from the previous samples who repeated both the olfactory functional assessment and the MRI examination after ~1 year. By comparing the newly derived subgroups, we observed that the increase in the structural connectivity index of the medial orbitofrontal cortex was not significant at follow-up, despite 10/18 COV+ subjects were still found hyposmic after ~1 year from SARS-CoV-2 infection. We concluded that the relative hyperconnectivity of the olfactory cortex to the medial orbitofrontal cortex could be, at least in some cases, an acute or reversible phenomenon linked to the recent SARS-CoV-2 infection with associated olfactory loss.

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来源期刊
Neural Plasticity
Neural Plasticity NEUROSCIENCES-
CiteScore
6.80
自引率
0.00%
发文量
77
审稿时长
16 weeks
期刊介绍: Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.
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