Gabriel Moraes de Oliveira, Fernando Augusto Barcelos Andrade, André Bahia Pereira, Rodrigo Silva Viza, Henrique Fernandes Gerspacher, Mateus da Costa Monteiro, Helton Oliveira Campos, Lucas Rios Drummond, Laura Hora Rios Leite, Cândido Celso Coimbra
{"title":"使用非甾体抗炎药会影响体能吗？系统回顾和荟萃分析。","authors":"Gabriel Moraes de Oliveira, Fernando Augusto Barcelos Andrade, André Bahia Pereira, Rodrigo Silva Viza, Henrique Fernandes Gerspacher, Mateus da Costa Monteiro, Helton Oliveira Campos, Lucas Rios Drummond, Laura Hora Rios Leite, Cândido Celso Coimbra","doi":"10.1080/00913847.2023.2220439","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aim to analyze the effects of ingesting non-steroidal anti-inflammatory drugs (NSAIDs) on physical performance, muscle strength, and muscle damage in three different moments: immediately, 24 and 48 h after resistance exercise practice.</p><p><strong>Methods: </strong>Relevant studies were researched in three databases (PubMed, Web of Science and SPORTDiscus) in April 2023. After excluding duplicates, the decision to include or exclude studies was made by two independent investigators in the following steps: (I) the study title; (II) the study abstract; and (III) the complete study manuscript. The following characteristics were recorded: (I) first author, (II) year of publication, (III) sample size, (IV) method of NSAIDs administration, (V) exercise protocol, and (VI) analyzed variable results. The studies selected were divided into trials that evaluated the effects of NSAIDs ingestion on performance indices of resistance exercise, endurance exercise and resistance training.</p><p><strong>Results: </strong>The meta-analysis, based only on resistance exercises, revealed that both performance and muscle strength were similar between placebo or NSAID treatment immediately and 24 h after resistance exercise practice. An ergolytic effect was found 48 hours after resistance exercise (mean effect size (ES) = -0.42; 95% CI: -0.71, -0.12; <i>p</i> = 0.132), as well as reduced muscle strength (ES = -0.50; 95% CI: -0.83, -0.16; <i>p</i> = 0.072). Additionally, NSAID use did not prevent muscle waste as seen by the unchanged CK plasma concentration at all timetables.</p><p><strong>Conclusion: </strong>The data of the present meta-analysis indicate that NSAID use is ineffective in improving resistance performance and muscle strength, as well as exercise recovery. When considering the practical application of using NSAIDs to improve exercise capacity and strength gains, the present data supports that consumption of analgesic drugs as an endurance performance enhancer or as a muscle anabolic must not be recommended.</p>","PeriodicalId":51268,"journal":{"name":"Physician and Sportsmedicine","volume":" ","pages":"207-216"},"PeriodicalIF":1.9000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is physical performance affected by non-steroidal anti-inflammatory drugs use? A systematic review and meta-analysis.\",\"authors\":\"Gabriel Moraes de Oliveira, Fernando Augusto Barcelos Andrade, André Bahia Pereira, Rodrigo Silva Viza, Henrique Fernandes Gerspacher, Mateus da Costa Monteiro, Helton Oliveira Campos, Lucas Rios Drummond, Laura Hora Rios Leite, Cândido Celso Coimbra\",\"doi\":\"10.1080/00913847.2023.2220439\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This systematic review and meta-analysis aim to analyze the effects of ingesting non-steroidal anti-inflammatory drugs (NSAIDs) on physical performance, muscle strength, and muscle damage in three different moments: immediately, 24 and 48 h after resistance exercise practice.</p><p><strong>Methods: </strong>Relevant studies were researched in three databases (PubMed, Web of Science and SPORTDiscus) in April 2023. After excluding duplicates, the decision to include or exclude studies was made by two independent investigators in the following steps: (I) the study title; (II) the study abstract; and (III) the complete study manuscript. The following characteristics were recorded: (I) first author, (II) year of publication, (III) sample size, (IV) method of NSAIDs administration, (V) exercise protocol, and (VI) analyzed variable results. The studies selected were divided into trials that evaluated the effects of NSAIDs ingestion on performance indices of resistance exercise, endurance exercise and resistance training.</p><p><strong>Results: </strong>The meta-analysis, based only on resistance exercises, revealed that both performance and muscle strength were similar between placebo or NSAID treatment immediately and 24 h after resistance exercise practice. An ergolytic effect was found 48 hours after resistance exercise (mean effect size (ES) = -0.42; 95% CI: -0.71, -0.12; <i>p</i> = 0.132), as well as reduced muscle strength (ES = -0.50; 95% CI: -0.83, -0.16; <i>p</i> = 0.072). Additionally, NSAID use did not prevent muscle waste as seen by the unchanged CK plasma concentration at all timetables.</p><p><strong>Conclusion: </strong>The data of the present meta-analysis indicate that NSAID use is ineffective in improving resistance performance and muscle strength, as well as exercise recovery. When considering the practical application of using NSAIDs to improve exercise capacity and strength gains, the present data supports that consumption of analgesic drugs as an endurance performance enhancer or as a muscle anabolic must not be recommended.</p>\",\"PeriodicalId\":51268,\"journal\":{\"name\":\"Physician and Sportsmedicine\",\"volume\":\" \",\"pages\":\"207-216\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physician and Sportsmedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/00913847.2023.2220439\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/6/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physician and Sportsmedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00913847.2023.2220439","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/8 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
Is physical performance affected by non-steroidal anti-inflammatory drugs use? A systematic review and meta-analysis.
Objective: This systematic review and meta-analysis aim to analyze the effects of ingesting non-steroidal anti-inflammatory drugs (NSAIDs) on physical performance, muscle strength, and muscle damage in three different moments: immediately, 24 and 48 h after resistance exercise practice.
Methods: Relevant studies were researched in three databases (PubMed, Web of Science and SPORTDiscus) in April 2023. After excluding duplicates, the decision to include or exclude studies was made by two independent investigators in the following steps: (I) the study title; (II) the study abstract; and (III) the complete study manuscript. The following characteristics were recorded: (I) first author, (II) year of publication, (III) sample size, (IV) method of NSAIDs administration, (V) exercise protocol, and (VI) analyzed variable results. The studies selected were divided into trials that evaluated the effects of NSAIDs ingestion on performance indices of resistance exercise, endurance exercise and resistance training.
Results: The meta-analysis, based only on resistance exercises, revealed that both performance and muscle strength were similar between placebo or NSAID treatment immediately and 24 h after resistance exercise practice. An ergolytic effect was found 48 hours after resistance exercise (mean effect size (ES) = -0.42; 95% CI: -0.71, -0.12; p = 0.132), as well as reduced muscle strength (ES = -0.50; 95% CI: -0.83, -0.16; p = 0.072). Additionally, NSAID use did not prevent muscle waste as seen by the unchanged CK plasma concentration at all timetables.
Conclusion: The data of the present meta-analysis indicate that NSAID use is ineffective in improving resistance performance and muscle strength, as well as exercise recovery. When considering the practical application of using NSAIDs to improve exercise capacity and strength gains, the present data supports that consumption of analgesic drugs as an endurance performance enhancer or as a muscle anabolic must not be recommended.
期刊介绍：
The Physician and Sportsmedicine is a peer-reviewed, clinically oriented publication for primary care physicians. We examine the latest drug discoveries to advance treatment and recovery, and take into account the medical aspects of exercise therapy for a given condition. We cover the latest primary care-focused treatments serving the needs of our active patient population, and assess the limits these treatments govern in stabilization and recovery.
The Physician and Sportsmedicine is a peer-to-peer method of communicating the latest research to aid primary care physicians’ advancement in methods of care and treatment. We routinely cover such topics as: managing chronic disease, surgical techniques in preventing and managing injuries, the latest advancements in treatments for helping patients lose weight, and related exercise and nutrition topics that can impact the patient during recovery and modification.
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