补充肌酸保护空间记忆和长期增强对抗慢性约束压力。

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2023-09-01 DOI:10.1097/FBP.0000000000000739
Zahra Bahari, Zohreh Jangravi, Boshra Hatef, Habib Valipour, Gholam Hossein Meftahi
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引用次数: 0

摘要

压力会导致许多精神疾病,包括记忆障碍,并威胁到一个人的健康。据报道,补充肌酸可能会影响认知过程。因此,在本研究中,我们研究了补充肌酸对慢性约束应激(CRS)大鼠海马CA1区记忆、突触可塑性和神经元树突的影响。将32只体重200 ~ 250 g的8周龄成年雄性Wistar大鼠随机分为对照组、应激组、肌酸组和应激+肌酸组(每组8只)。连续14 d,每天诱导6 h,通过在动物饮用水中溶解肌酸(2 g/kg体重/天)补充肌酸,连续14 d。采用巴恩斯迷宫和穿梭箱对空间记忆和被动回避记忆进行测试。采用体内场电位记录和高尔基-考克斯染色研究CA1锥体神经元的长期增强(LTP)和树突树突化。慢性应激损害了应激大鼠的空间记忆、LTP参数失调、CA1锥体神经元树突数量减少,而补充肌酸可以改善应激大鼠的这些影响。补充肌酸可以改善CRS诱导的海马CA1神经元的空间记忆缺陷和突触可塑性丧失,可能是通过减轻树突树突损伤来实现的。然而,对其机理的理解还需要进一步的研究。
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Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress.

Stress contributes to numerous psychopathologies, including memory impairment, and threatens one's well-being. It has been reported that creatine supplementation potentially influences cognitive processing. Hence, in this study, we examined the effects of creatine supplementation on memory, synaptic plasticity, and neuronal arborization in the CA1 region of the hippocampus in rats under chronic restraint stress (CRS). Thirty-two adult male Wistar rats (8 weeks old) weighing 200-250 g were randomly divided into four groups (n = 8/per group): control, stress, creatine, and stress + creatine. CRS was induced for 6 h per day for 14 days, and creatine supplementation was carried out by dissolving creatine (2 g/kg body weight per day) in the animals' drinking water for 14 days. We used the Barnes maze and shuttle box for spatial and passive avoidance memory examination. The in-vivo field potential recording and Golgi-Cox staining were also used to investigate long-term potentiation (LTP) and dendrite arborization in the CA1 pyramidal neurons. Chronic stress impaired spatial memory, dysregulated LTP parameters, and decreased the number of dendrites in the CA1 pyramidal neurons of stressed rats, and creatine supplementation modified these effects in stressed rats. It seems that creatine supplementation can improve spatial memory deficits and synaptic plasticity loss induced by CRS in hippocampal CA1 neurons, possibly by reducing the dendrite arborization damages. However, understanding its mechanism needs further investigation.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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