Huiyul Park, Kye-Yeung Park, Minki Kim, Hoon-Ki Park, Hwan-Sik Hwang
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Pearson correlation analysis showed a stronger correlation of SUA level with the fatty liver index (<i>r</i> = 0.40, <i>P</i> < 0.001) than the correlation with serum ALT level (<i>r</i> = 0.28, <i>P</i> < 0.001), or NFS (<i>r</i> = 0.018, <i>P</i> = 0.51). SUA levels in patients with NAFLD and an abnormal liver function test (LFT) result were significantly higher than levels in patients without NAFLD and abnormal LFT results. By contrast, there was no significant association of SUA level with NFS grade. When age, male sex, body mass index, the presence of hypertension, diabetic mellitus, and NAFLD, abnormality of ALT level, and SUA level were included in binary logistic regression to evaluate risk factors for elevated NFS grade, hyperuricemia was not significantly associated with NFS grade (OR = 0.94, <i>P</i> = 0.75).</p><p><strong>Conclusion: </strong>Pearson correlation and logistic regression together indicated SUA level is more closely associated with hepatic steatosis than abnormal liver function test or hepatic fibrosis.</p>","PeriodicalId":8501,"journal":{"name":"Asian Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321156/pdf/","citationCount":"1","resultStr":"{\"title\":\"Association between serum uric acid level and non-alcoholic fatty liver disease in Koreans.\",\"authors\":\"Huiyul Park, Kye-Yeung Park, Minki Kim, Hoon-Ki Park, Hwan-Sik Hwang\",\"doi\":\"10.2478/abm-2022-0003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The association between serum uric acid (SUA) levels and non-alcoholic fatty liver disease (NAFLD) is controversial.</p><p><strong>Objectives: </strong>We compared the association of SUA levels with NAFLD, abnormal alanine transferase (ALT), and the degree of liver fibrosis to clarify the association of SUA levels with NAFLD.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional study. Adult patients who underwent a health check-up (N = 1,343) were included for analysis. Fatty liver was diagnosed by abdominal ultrasonography. The degree of liver fibrosis was determined using the NAFLD fibrosis score (NFS). Pearson correlation analysis showed a stronger correlation of SUA level with the fatty liver index (<i>r</i> = 0.40, <i>P</i> < 0.001) than the correlation with serum ALT level (<i>r</i> = 0.28, <i>P</i> < 0.001), or NFS (<i>r</i> = 0.018, <i>P</i> = 0.51). SUA levels in patients with NAFLD and an abnormal liver function test (LFT) result were significantly higher than levels in patients without NAFLD and abnormal LFT results. By contrast, there was no significant association of SUA level with NFS grade. 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引用次数: 1
摘要
背景:血清尿酸(SUA)水平与非酒精性脂肪肝(NAFLD)之间的关系是有争议的。目的:我们比较SUA水平与NAFLD、丙氨酸转移酶(ALT)异常和肝纤维化程度的关系,以阐明SUA水平与NAFLD的关系。方法:我们进行了回顾性横断面研究。接受健康检查的成年患者(N = 1343)被纳入分析。腹部超声诊断脂肪肝。采用NAFLD纤维化评分(NFS)确定肝纤维化程度。Pearson相关分析显示,SUA水平与脂肪肝指数(r = 0.40, P < 0.001)的相关性强于与血清ALT水平(r = 0.28, P < 0.001)或NFS水平(r = 0.018, P = 0.51)的相关性。NAFLD和肝功能检查(LFT)结果异常的患者的SUA水平显著高于无NAFLD和LFT结果异常的患者。相比之下,SUA水平与NFS分级无显著相关性。当将年龄、男性、体重指数、是否存在高血压、糖尿病、NAFLD、ALT水平异常、SUA水平纳入二元logistic回归评估NFS分级升高的危险因素时,高尿酸血症与NFS分级无显著相关性(OR = 0.94, P = 0.75)。结论:Pearson相关分析和logistic回归分析表明,与肝功能异常和肝纤维化相比,SUA水平与肝脂肪变性的关系更为密切。
Association between serum uric acid level and non-alcoholic fatty liver disease in Koreans.
Background: The association between serum uric acid (SUA) levels and non-alcoholic fatty liver disease (NAFLD) is controversial.
Objectives: We compared the association of SUA levels with NAFLD, abnormal alanine transferase (ALT), and the degree of liver fibrosis to clarify the association of SUA levels with NAFLD.
Methods: We conducted a retrospective cross-sectional study. Adult patients who underwent a health check-up (N = 1,343) were included for analysis. Fatty liver was diagnosed by abdominal ultrasonography. The degree of liver fibrosis was determined using the NAFLD fibrosis score (NFS). Pearson correlation analysis showed a stronger correlation of SUA level with the fatty liver index (r = 0.40, P < 0.001) than the correlation with serum ALT level (r = 0.28, P < 0.001), or NFS (r = 0.018, P = 0.51). SUA levels in patients with NAFLD and an abnormal liver function test (LFT) result were significantly higher than levels in patients without NAFLD and abnormal LFT results. By contrast, there was no significant association of SUA level with NFS grade. When age, male sex, body mass index, the presence of hypertension, diabetic mellitus, and NAFLD, abnormality of ALT level, and SUA level were included in binary logistic regression to evaluate risk factors for elevated NFS grade, hyperuricemia was not significantly associated with NFS grade (OR = 0.94, P = 0.75).
Conclusion: Pearson correlation and logistic regression together indicated SUA level is more closely associated with hepatic steatosis than abnormal liver function test or hepatic fibrosis.
期刊介绍:
Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries
Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.