设计相关的临床前啮齿动物模型,以研究营养、肥胖、新陈代谢和癌症之间的联系。

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2021-10-11 Epub Date: 2021-08-06 DOI:10.1146/annurev-nutr-120420-032437
Elaine M Glenny, Michael F Coleman, Erin D Giles, Elizabeth A Wellberg, Stephen D Hursting
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引用次数: 0

摘要

饮食和营养与癌症的预防、生长和治疗反应密切相关。临床前啮齿类动物模型是生物医学研究的基石,对于我们了解癌症与饮食之间的关系以及开发有效的治疗方法仍然非常重要。然而,将有前景的研究成果从实验室转化到临床的成功率却不尽如人意。精心设计的啮齿类动物模型对于提高基础科学对临床治疗方案的影响至关重要。本综述讨论了在设计临床前癌症模型时应考虑的基本实验因素,重点是将这些模型纳入有关饮食、营养和新陈代谢的研究中。本综述的目的是:(a) 深入探讨为肥胖、营养和代谢研究设计癌症模型时的相关注意事项;(b) 找出选择啮齿动物模型时的常见误区;(c) 讨论现有临床前模型的优势和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer.

Diet and nutrition are intricately related to cancer prevention, growth, and treatment response. Preclinical rodent models are a cornerstone to biomedical research and remain instrumental in our understanding of the relationship between cancer and diet and in the development of effective therapeutics. However, the success rate of translating promising findings from the bench to the bedside is suboptimal. Well-designed rodent models will be crucial to improving the impact basic science has on clinical treatment options. This review discusses essential experimental factors to consider when designing a preclinical cancer model with an emphasis on incorporatingthese models into studies interrogating diet, nutrition, and metabolism. The aims of this review are to (a) provide insight into relevant considerations when designing cancer models for obesity, nutrition, and metabolism research; (b) identify common pitfalls when selecting a rodent model; and (c) discuss strengths and limitations of available preclinical models.

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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
期刊最新文献
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