鲁拉西酮作为氟西汀的附加治疗药物用于伴有限制性厌食症的强迫症:病例报告。

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY International Clinical Psychopharmacology Pub Date : 2024-05-01 Epub Date: 2023-08-09 DOI:10.1097/YIC.0000000000000502
Laura Orsolini, Silvia Bellagamba, Umberto Volpe
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引用次数: 0

摘要

强迫症(OCD)是一种普遍的致残性障碍,可能与神经性厌食症等其他精神疾病重叠。最近的指南建议,对于出现残余症状的强迫症患者,在使用选择性血清素再摄取抑制剂(SSRIs)的基础上,加用小剂量第二代抗精神病药物。我们在此报告了一例临床病例,患者是一名 45 岁的女性,患有严重的强迫症并合并神经性厌食症(限制型)(AN-r)。在基线和6个月的随访期间,我们对患者进行了临床总体印象-严重程度、症状检查表-90项、Y-BOCS-II(雅勒-布朗强迫症量表)和EDI-3(进食障碍量表)测试。经过 1 个月的强化治疗后,在 Y-BOCS-II 强迫症状(Y-BOCS 减少≥35%)和 EDI-3 进食症状方面观察到了显著的临床反应。3 个月后完全缓解(Y-BOCS 评分≤14)(P
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Lurasidone as add-on to fluoxetine in obsessive-compulsive disorder with comorbid restrictive anorexia: a case report.

Obsessive-compulsive disorder (OCD) is a pervasive disabling disorder that may overlap with other psychiatric conditions, including anorexia nervosa. Recent guidelines recommend low doses of second-generation antipsychotics as add-on therapy to selective serotonin reuptake inhibitors (SSRIs) for those patients presenting OCD who display residual symptomatology. Here we report a clinical case of a 45-years-old woman affected by severe OCD in comorbidity with anorexia nervosa, restrictive type (AN-r), treated with fluoxetine (titrated up to 40 mg/day) in augmentation with low doses of lurasidone (37 mg/day). At baseline and during a 6 months-follow-up we administered Clinical Global Impression-Severity, Symptom Checklist-90 items, Y-BOCS-II (Yale-Brown Obsessive Compulsive Scale) and EDI-3 (Eating Disorder Inventory). After 1 month of augmentation treatment, a clinically significant response was observed on obsessive symptoms at Y-BOCS-II (≥35% Y-BOCS reduction) and eating symptomatology at EDI-3. Full remission was reported after 3 months (Y-BOCS scoring ≤14) ( P  < 0.01). Further longitudinal and real-world effectiveness studies should be implemented to confirm these novel results, to investigate the potential of lurasidone as add-on strategy to SSRI in poor responder OCD patients, including treatment-resistant-OCD (tr-OCD), as well as in improving eating disorder symptomatology, whereas there is comorbidity with AN-r.

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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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