非塞汀的抗肿瘤作用:揭示机制和未来治疗的靶点。

IF 1.2 Q4 GENETICS & HEREDITY Global Medical Genetics Pub Date : 2023-09-01 DOI:10.1055/s-0043-1772219
Eskandar Qaed, Bandar Al-Hamyari, Ahmed Al-Maamari, Abdullah Qaid, Haneen Alademy, Marwan Almoiliqy, Jean Claude Munyemana, Murad Al-Nusaif, Jameel Alafifi, Eman Alyafeai, Mohammed Safi, Zhaohong Geng, Zeyao Tang, Xiaodong Ma
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引用次数: 1

摘要

癌症仍然是一项重大的全球健康挑战,也是导致死亡的主要原因。在水果和蔬菜中发现的类黄酮因其潜在的抗癌特性而受到关注。在草莓、苹果、洋葱和其他植物中大量存在的非瑟酮,已经成为一种很有希望的癌症预防药物。流行病学研究将富含这些食物的饮食与降低癌症风险联系起来,引发了对非瑟酮功效的广泛研究。目的全面探讨非瑟酮抗癌作用的分子机制,探讨其与其他抗癌药物的协同作用。此外,本文综述了非瑟酮对各种癌症的治疗和预防作用。方法系统分析现有科学文献,包括与非瑟酮抗癌特性相关的研究论文、临床试验和综述论文。我们检索了信誉良好的数据库,并对选定的研究进行了严格评估,以提取有关非塞汀作用机制及其与其他抗癌药物相互作用的基本信息。结果临床前试验表明,非瑟酮通过改变细胞周期、诱导细胞凋亡和激活自噬信号通路等机制抑制癌细胞生长。此外,非瑟酮降低活性氧水平,有助于其整体抗癌潜力。对其与其他抗癌药物的协同作用的研究表明联合治疗的潜力。结论非瑟酮是一种富含水果和蔬菜的生物活性类黄酮,通过多种作用机制显示出良好的抗癌作用。临床前试验为进一步探索人体临床试验提供了基础。了解非瑟酮的分子机制对于开发新颖、安全、有效的癌症预防和治疗策略至关重要。与其他抗癌药物的潜在协同作用为联合治疗开辟了新的途径,增强了癌症管理方法和全球健康结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies.

Background  Cancer remains a critical global health challenge and a leading cause of mortality. Flavonoids found in fruits and vegetables have gained attention for their potential anti-cancer properties. Fisetin, abundantly present in strawberries, apples, onions, and other plant sources, has emerged as a promising candidate for cancer prevention. Epidemiological studies linking a diet rich in these foods to lower cancer risk have sparked extensive research on fisetin's efficacy. Objective  This review aims to comprehensively explore the molecular mechanisms of fisetin's anticancer properties and investigate its potential synergistic effects with other anticancer drugs. Furthermore, the review examines the therapeutic and preventive effects of fisetin against various cancers. Methods  A systematic analysis of the available scientific literature was conducted, including research articles, clinical trials, and review papers related to fisetin's anticancer properties. Reputable databases were searched, and selected studies were critically evaluated to extract essential information on fisetin's mechanisms of action and its interactions with other anticancer drugs. Results  Preclinical trials have demonstrated that fisetin inhibits cancer cell growth through mechanisms such as cell cycle alteration, induction of apoptosis, and activation of the autophagy signaling pathway. Additionally, fisetin reduces reactive oxygen species levels, contributing to its overall anticancer potential. Investigation of its synergistic effects with other anticancer drugs suggests potential for combination therapies. Conclusion  Fisetin, a bioactive flavonoid abundant in fruits and vegetables, exhibits promising anticancer properties through multiple mechanisms of action. Preclinical trials provide a foundation for further exploration in human clinical trials. Understanding fisetin's molecular mechanisms is vital for developing novel, safe, and effective cancer prevention and treatment strategies. The potential synergy with other anticancer drugs opens new avenues for combination therapies, enhancing cancer management approaches and global health outcomes.

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来源期刊
Global Medical Genetics
Global Medical Genetics GENETICS & HEREDITY-
自引率
11.80%
发文量
30
审稿时长
14 weeks
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