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An Efficient Preparation of Trisubstituted Pyridines

有机合成与工艺文献分享 2024-11-15 07:30

文章摘要

本文介绍了一种高效制备三取代吡啶的方法。Merck公司报道了α-芳基酮与乙烯基二胺六氟磷酸盐反应生成相应的3-芳基吡啶。该环化反应在含有吸电子基团的乙烯基盐中表现出良好的至优异的产率。此外，该反应被应用于COX-2抑制剂及其一系列类似物的制备。在另一篇文献中，研究小组描述了乙烯基物种的制备。六氟磷酸盐易于处理，为有机阳离子的常用高氯酸盐和氯化物盐提供了替代方案。

An Efficient Preparation of Trisubstituted Pyridines

查看文献： Annulation of Ketones with Vinamidinium Hexafluorophosphate Salts: An Efficient Preparation of Trisubstituted Pyridines
查看期刊：Organic Letters

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