文献互助智能选刊最新文献

高级搜索发布求助登录注册

首页 > 化学

JC|2410|PNAS, Cell Chemical Biology

谢然课题组 2024-11-25 09:00

文章摘要

本文探讨了烯醇化酶1（ENO1）的O-GlcNAcylation在结直肠癌中的双重调节作用，即有氧糖酵解和免疫逃避。研究发现，ENO1的T19和S249位点的糖基化修饰分别影响糖酵解过程和PD-L1表达，从而调节细胞增殖和免疫反应。阻断这些位点的糖基化可抑制肿瘤生长并增强抗肿瘤免疫反应。研究结果揭示了O-GlcNAcylation在肿瘤生长中的关键作用，并为开发新的治疗策略提供了理论基础。

JC|2410|PNAS, Cell Chemical Biology

查看文献： O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer.
查看期刊：Proceedings of the National Academy of Sciences of the United States of America

本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。

推荐文献

iScience

iScience

The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo

DOI: 10.1016/j.isci.2024.111055 Pub Date : 2024-11-15

IF 4.6 2区综合性期刊 Q1

iScience

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

Using computational modeling to validate the onset of productive determiner-noun combinations in English-learning children.

DOI: 10.1073/pnas.2316527121 Pub Date : 2024-12-10 Date: 2024/11/21 0:00:00

IF 9.4 1区综合性期刊 Q1

Proceedings of the National Academy of Sciences of the United States of America

Science Bulletin

Science Bulletin

The Tibetan Plateau darkening initiates positive feedback through the Arctic.

DOI: 10.1016/j.scib.2024.11.015 Pub Date : 2024-11-13

IF 18.8 1区综合性期刊 Q1

Science Bulletin

最新文章

JC|2410|Nature Nanotechnology, Science Translational Medicine

JC|2410|Nature Nanotechnology, Science Translational Medicine

2024年10月相关文献导读Nature NanotechnologyCombinatorial design of siloxaneincorporated lipid nanoparticles

22小时前

JC|2410|ACS Infectious Diseases, Science Advances, Nat. Methods

JC|2410|ACS Infectious Diseases, Science Advances, Nat. Methods

2024年10月相关文献导读ACS Infectious DiseasesVolume 10，Issue 10The HCoV-HKU1 N‑Terminal Domain Binds a Wide

22小时前

JC|2410|ACS Chemical Biology, Analytical Chemistry

JC|2410|ACS Chemical Biology, Analytical Chemistry

2024年10月相关文献导读ACS Chemical BiologyVolume 19, Issue 10Glucose Transporter-Targeting Chimeras Enabling

22小时前

JC|2410|Bioconjugate Chemistry, RSC Chemical Biology

JC|2410|Bioconjugate Chemistry, RSC Chemical Biology

2024年10月相关文献导读Bioconjugate ChemistryVolume 35, Issue 10Strategy for Construction of Homogeneous Glyc

22小时前

Book学术官方微信

Book学术文献互助

Book学术文献互助群
群号：481959085

文献互助智能选刊最新文献互助须知联系我们：info@booksci.cn

Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。

Copyright © 2023 Book学术 All rights reserved.

京公网安备 11010802042870号京ICP备2023020795号-1