首页 > 化学

Practical Synthesis of N-Unprotected β-Amino Esters

有机合成与工艺文献分享 2024-12-23 08:09
文章摘要
本文介绍了N-未保护的β-氨基酯的实际合成方法，特别是手性合成中间体甲基(R)-3-氨基丁酸酯(4a)的制备。传统的合成方法依赖于从甲基乙酰乙酸酯(2a)开始的逐步不对称氢化过程。2011年，Takasago的研究人员测试了一种公斤级合成方法，使用NH4OAc直接以86%的产率和95%的ee值合成了手性氨基酯1a，并通过结晶为TsOH盐进一步提高了ee值至>99%。文章还讨论了可能的副反应路径，包括酮的竞争性还原、二聚体类似物的形成和消除产物的形成，并提出了抑制这些副反应的方法。
Practical Synthesis of N-Unprotected β-Amino Esters
查看文献： Practical, Catalytic Enantioselective Hydrogenation to Synthesize N-Unprotected β-Amino Esters
查看期刊：Organic Process Research & Development
阅读全文
本站注明稿件来源为其他媒体的文/图等稿件均为转载稿，本站转载出于非商业性的教育和科研之目的，并不意味着赞同其观点或证实其内容的真实性。如转载稿涉及版权等问题，请作者速来电或来函联系。
推荐文献
ACS Applied Polymer Materials ACS Applied Polymer Materials
Issue Publication Information
DOI: 10.1021/apv008i002_2033340 Pub Date : 2026-01-23
IF 4.7 2区 化学 Q2
ACS Applied Polymer Materials
Accounts of Chemical Research Accounts of Chemical Research
Correction to “Expanding Horizons in Quantum Chemical Studies: The Versatile Power of MRSF-TDDFT”
DOI: 10.1021/acs.accounts.6c00063 Pub Date : 2026-02-04
IF 18.3 1区 化学 Q1
Accounts of Chemical Research
Organic Process Research & Development Organic Process Research & Development
Development of a Robust, Efficient, and Scalable Process for the Synthesis of Bisacodyl
DOI: 10.1021/acs.oprd.5c00465 Pub Date : 2026-02-06
IF 3.4 3区 化学 Q2
Organic Process Research & Development
最新文章
A High Yield Continuous-Flow Nitration Process
A High Yield Continuous-Flow Nitration Process
Org. Process Res. Dev. 2025, 29, 3150−3158. DOI: 10.1021/acs.oprd.5c00273◆This study presents an eff
2025-12-31
New Robust Synthetic Strategy toward FAPI-46
New Robust Synthetic Strategy toward FAPI-46
Org. Process Res. Dev. 2025, 29, 3138−3149. DOI: 10.1021/acs.oprd.5c00267◆The radiolabeled FAPI-46 h
2025-12-29
Optimizing the CHF6523 Isocoumarin Core Scaffold
Optimizing the CHF6523 Isocoumarin Core Scaffold
Org. Process Res. Dev. 2025, 29, 1809−1821. DOI: 10.1021/acs.oprd.5c00133◆A programmed approach for
2025-12-29
Evolution of the Synthesis Route for CC-99677 (2)
Evolution of the Synthesis Route for CC-99677 (2)
Org. Process Res. Dev. 2025, 29, 3159−3172. DOI: 10.1021/acs.oprd.5c00278◆A new route to intermediat
2025-12-26
有机合成与工艺文献分享
A High Yield Continuous-Flow Nitration Process
A High Yield Continuous-Flow Nitration Process 2025-12-31
New Robust Synthetic Strategy toward FAPI-46
New Robust Synthetic Strategy toward FAPI-46 2025-12-29
Optimizing the CHF6523 Isocoumarin Core Scaffold
Optimizing the CHF6523 Isocoumarin Core Scaffold 2025-12-29
Evolution of the Synthesis Route for CC-99677 (2)
Evolution of the Synthesis Route for CC-99677 (2) 2025-12-26
Evolution of the Synthesis Route for CC-99677 (1)
Evolution of the Synthesis Route for CC-99677 (1) 2025-12-24
热门类别
综合性期刊 物理 法学 地球科学 历史学
相关文章
上海交大中英国际低碳学院姚琳课题组与波兰West Pomeranian University of Technology in Szczecin陈学成教授联合诚聘博士后 哈尔滨工业大学：均温板-石墨烯薄膜，热界面材料 | Transactions of Materials Research 德国Karlsruhe Institute of Technology招收电化学储能及联合培养CSC博士等 Research|N型SnSe多晶热电材料：液相烧结赋予高性能 德国Karlsruhe Institute of Technology招收电化学储能及联合培养CSC博士等
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1