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An Improved Synthesis of 2-Bromo-4-nitro-1H-imidazole

有机合成与工艺文献分享 2025-04-05 07:30
文章摘要
本文介绍了一种改进的2-溴-4-硝基咪唑的合成方法。背景方面，现有的合成方法在工艺安全性和收率上存在优化空间。研究目的是通过改进反应条件，避免使用大规模操作困难的分子溴，转而采用氢溴酸和过氧化氢原位生成溴的方法。结论表明，该方法在公斤级规模上实现了较高的产物纯度和收率，但需要进一步的安全研究以扩大反应规模。
An Improved Synthesis of 2-Bromo-4-nitro-1H-imidazole
查看文献： An Improved Kilogram-Scale Synthesis of 2-Bromo-4-nitro-1H-imidazole: A Key Building Block of Nitroimidazole Drugs
查看期刊：Organic Process Research & Development
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