D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS

PLN-74809, a Dual-Selective Inhibitor of Integrins αvβ6 and αvβ1, Shows Dose-Dependent Target Engagement in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF)

Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5254 J. Mooney, K. Morris, S. Jacobs, E. Lefebvre, G. Cosgrove, S. Wong, J. Bellini, M. Jurek, S. Turner, M. Decaris, R. Jiron, B. Williams, H. Duan, R. Gunn, G. Rizzo, M. Wardak, H.H. Guo

Discovery of Remodilins - a Novel Class of Small Molecules That Inhibit Myofibroblast Differentiation of Human Lung Fibroblasts and Pulmonary Fibrosis in Mice

Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5250 B. Chen, C.Y. Park, L. Diane, E. B. Reed, J. Wang, R. Krishnan, V. Gurvich, S. Byrn, D. Maloney, M. Rosner, N. Prabhakar, J. Nanduri, G. Mutlu, R. Amy, S. White, B. Laxman, S. Kales, D. Tao, G. Bantukallu, A. Simeonov, M. Muzzio, R. Moellering, J. Huang, L. Hwang, D. Mccormick, J. Fredberg, J. Solway, N. O. Dulin

Plasma Biomarkers of Inflammation and Lung Injury in Obese Surgical Patients Ventilated with Low vs. High Positive End-Expiratory Pressure and Lung Recruitment Maneuvers - A Substudy of the PROBESE Randomized Controlled Trial

Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5252 M. Scharffenberg, T. Bluth, J. Wittenstein, R. Huhle, T. Koch, P. Pelosi, M. Schulz, J. Sprung, M. Gama de Abreu