Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5254
J. Mooney, K. Morris, S. Jacobs, E. Lefebvre, G. Cosgrove, S. Wong, J. Bellini, M. Jurek, S. Turner, M. Decaris, R. Jiron, B. Williams, H. Duan, R. Gunn, G. Rizzo, M. Wardak, H.H. Guo
{"title":"PLN-74809, a Dual-Selective Inhibitor of Integrins αvβ6 and αvβ1, Shows Dose-Dependent Target Engagement in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF)","authors":"J. Mooney, K. Morris, S. Jacobs, E. Lefebvre, G. Cosgrove, S. Wong, J. Bellini, M. Jurek, S. Turner, M. Decaris, R. Jiron, B. Williams, H. Duan, R. Gunn, G. Rizzo, M. Wardak, H.H. Guo","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5254","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5254","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125756817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5250
B. Chen, C.Y. Park, L. Diane, E. B. Reed, J. Wang, R. Krishnan, V. Gurvich, S. Byrn, D. Maloney, M. Rosner, N. Prabhakar, J. Nanduri, G. Mutlu, R. Amy, S. White, B. Laxman, S. Kales, D. Tao, G. Bantukallu, A. Simeonov, M. Muzzio, R. Moellering, J. Huang, L. Hwang, D. Mccormick, J. Fredberg, J. Solway, N. O. Dulin
{"title":"Discovery of Remodilins - a Novel Class of Small Molecules That Inhibit Myofibroblast Differentiation of Human Lung Fibroblasts and Pulmonary Fibrosis in Mice","authors":"B. Chen, C.Y. Park, L. Diane, E. B. Reed, J. Wang, R. Krishnan, V. Gurvich, S. Byrn, D. Maloney, M. Rosner, N. Prabhakar, J. Nanduri, G. Mutlu, R. Amy, S. White, B. Laxman, S. Kales, D. Tao, G. Bantukallu, A. Simeonov, M. Muzzio, R. Moellering, J. Huang, L. Hwang, D. Mccormick, J. Fredberg, J. Solway, N. O. Dulin","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5250","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5250","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115655970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5252
M. Scharffenberg, T. Bluth, J. Wittenstein, R. Huhle, T. Koch, P. Pelosi, M. Schulz, J. Sprung, M. Gama de Abreu
{"title":"Plasma Biomarkers of Inflammation and Lung Injury in Obese Surgical Patients Ventilated with Low vs. High Positive End-Expiratory Pressure and Lung Recruitment Maneuvers - A Substudy of the PROBESE Randomized Controlled Trial","authors":"M. Scharffenberg, T. Bluth, J. Wittenstein, R. Huhle, T. Koch, P. Pelosi, M. Schulz, J. Sprung, M. Gama de Abreu","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5252","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5252","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121244068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5256
J. Wittenstein, M. Scharffenberg, J. Fröhlich, C. Rothmann, X. Ran, Y. Zhang, Y. Chai, X. Yang, S. Müller, T. Koch, R. Huhle, M. Gama de Abreu
{"title":"Effects of Different Levels of Positive End-Expiratory Pressure on Regional Distribution of Pulmonary Perfusion During One-Lung-Ventilation in Pigs","authors":"J. Wittenstein, M. Scharffenberg, J. Fröhlich, C. Rothmann, X. Ran, Y. Zhang, Y. Chai, X. Yang, S. Müller, T. Koch, R. Huhle, M. Gama de Abreu","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5256","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5256","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129044180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5805
J.E. Peabody Lever, S. S. Hussain, H. Kim, E. Onuoha, M.Q. Sonnier, S. Gowda, D. Stanford, J. P. Kennemur, S. Thomas, E. McMillian, S. Samuel, Q. Li, J. Campos-Gómez, S.E. Phillips, S. Rowe
{"title":"Aged Ferrets Demonstrate Decreased Whole Lung Mucociliary Clearance at Baseline and Worse Fibrotic Remodeling Following Bleomycin Injury Compared to Young Ferrets","authors":"J.E. Peabody Lever, S. S. Hussain, H. Kim, E. Onuoha, M.Q. Sonnier, S. Gowda, D. Stanford, J. P. Kennemur, S. Thomas, E. McMillian, S. Samuel, Q. Li, J. Campos-Gómez, S.E. Phillips, S. Rowe","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5805","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5805","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121825765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5258
G. Povysil, J. Todd, A. Allen, D. Dilling, H.J. Kim, M. Neely, I. Noth, Z. Ren, L. Snyder, M. Strek, A. Swaminathan, D. Zhang, C. Hesslinger, T. Leonard, D. Goldstein, S. Palmer, on behalf of the IPF-PRO Registry investigators
{"title":"Gene-Based Collapsing Genetic Analyses to Identify Rare Protein-Coding Variants Associated with Susceptibility to Idiopathic Pulmonary Fibrosis (IPF): Data from the IPF-PRO Registry","authors":"G. Povysil, J. Todd, A. Allen, D. Dilling, H.J. Kim, M. Neely, I. Noth, Z. Ren, L. Snyder, M. Strek, A. Swaminathan, D. Zhang, C. Hesslinger, T. Leonard, D. Goldstein, S. Palmer, on behalf of the IPF-PRO Registry investigators","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5258","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5258","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134644879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5247
M. Osovskaya, J. Bilodeaux, A. Wallbank, H. Farooqi, B.J. Smith
{"title":"Heterogeneous Changes in Airspace Morphometry During Murine Acute Lung Injury","authors":"M. Osovskaya, J. Bilodeaux, A. Wallbank, H. Farooqi, B.J. Smith","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5247","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5247","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133329183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5257
B.J. Smith, J. Bilodeaux, A. Wallbank, H. Farooqi, A. Benjamin
{"title":"The Effect of Training Dataset Composition on Model Predictive Accuracy in Two-Hit Models of Acute- and Ventilator-Induced Lung Injury","authors":"B.J. Smith, J. Bilodeaux, A. Wallbank, H. Farooqi, A. Benjamin","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5257","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5257","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116235672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5248
S. Orfanos, G. Cao, B. Deeney, V. Parikh, R. Panettieri
{"title":"Treprostinil, an EP-2 Agonist, Decreases Lung Fibroblasts Extra-Cellular Matrix Production in a cAMP Dependent Manner","authors":"S. Orfanos, G. Cao, B. Deeney, V. Parikh, R. Panettieri","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5248","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5248","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125056584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5246
R. Huhle, M. Scharffenberg, J. Wittenstein, J. Zhang, X. Ran, A. Braune, T. Koch, J. Kotzerke, M. Gama de Abreu
{"title":"Association of Dynamic and Static Mechanical Energy and Neutrophilic Inflammation in Experimental Acute Lung Injury in Pigs","authors":"R. Huhle, M. Scharffenberg, J. Wittenstein, J. Zhang, X. Ran, A. Braune, T. Koch, J. Kotzerke, M. Gama de Abreu","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5246","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5246","url":null,"abstract":"","PeriodicalId":179165,"journal":{"name":"D30. THE INJURED LUNG: MECHANISMS AND THERAPEUTIC TARGETS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126902163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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