Poster Presentations - Proffered Abstracts

Abstract P165: MRTX1719: A first-in-class MTA-cooperative PRMT5 inhibitor that selectively elicits antitumor activity in MTAP/CDKN2A deleted cancer models

Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p165 Christopher R. Smith, Lars D. Engstrom, S. Kulyk, Ruth Aranda, Laurie Waters, K. Moya, Vickie Bowcut, Allan Hebbert, David Trinh, David M Briere, J. Lawson, Jeff Clarine, L. Rahbaek, J. Christensen, M. Marx, P. Olson

Abstract P025: NUC-3373 is a more potent inhibitor of thymidylate synthase than 5-FU and reduces generation of toxic metabolites

Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p025 J. Bré, A. Dickson, O. Read, Ying Zhang, P. Mullen, C. Czekster, D. Harrison

Abstract P240: Benchmarking the novel dual-MEK inhibitor, IMM-1-104, head-to-head and in combination with sotorasib (AMG-510) in the MIA PaCa-2 (KRAS-G12C) pancreatic cancer xenograft model

Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p240 Peter J. King, A. Axel, Kevin D. Fowler, S. Kolitz, S. Barrett, B. Zeskind, B. Hall