Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p165
Christopher R. Smith, Lars D. Engstrom, S. Kulyk, Ruth Aranda, Laurie Waters, K. Moya, Vickie Bowcut, Allan Hebbert, David Trinh, David M Briere, J. Lawson, Jeff Clarine, L. Rahbaek, J. Christensen, M. Marx, P. Olson
{"title":"Abstract P165: MRTX1719: A first-in-class MTA-cooperative PRMT5 inhibitor that selectively elicits antitumor activity in MTAP/CDKN2A deleted cancer models","authors":"Christopher R. Smith, Lars D. Engstrom, S. Kulyk, Ruth Aranda, Laurie Waters, K. Moya, Vickie Bowcut, Allan Hebbert, David Trinh, David M Briere, J. Lawson, Jeff Clarine, L. Rahbaek, J. Christensen, M. Marx, P. Olson","doi":"10.1158/1535-7163.targ-21-p165","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p165","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74510898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p025
J. Bré, A. Dickson, O. Read, Ying Zhang, P. Mullen, C. Czekster, D. Harrison
{"title":"Abstract P025: NUC-3373 is a more potent inhibitor of thymidylate synthase than 5-FU and reduces generation of toxic metabolites","authors":"J. Bré, A. Dickson, O. Read, Ying Zhang, P. Mullen, C. Czekster, D. Harrison","doi":"10.1158/1535-7163.targ-21-p025","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p025","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84313784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p240
Peter J. King, A. Axel, Kevin D. Fowler, S. Kolitz, S. Barrett, B. Zeskind, B. Hall
{"title":"Abstract P240: Benchmarking the novel dual-MEK inhibitor, IMM-1-104, head-to-head and in combination with sotorasib (AMG-510) in the MIA PaCa-2 (KRAS-G12C) pancreatic cancer xenograft model","authors":"Peter J. King, A. Axel, Kevin D. Fowler, S. Kolitz, S. Barrett, B. Zeskind, B. Hall","doi":"10.1158/1535-7163.targ-21-p240","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p240","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84942551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p229
Yoon-Chi Han, Pui Yee Ng, Ryan Schulz, S. Yang, A. Lelo, Luisa Shin, M. O’Connor, I. Jewett, N. Ishiyama, D. Romashko, S. Thakur, A. Salomatov, S. Smith, E. Buck, Christopher Roberts, M. Lucas, Tai-an Lin
{"title":"Abstract P229: Pre-clinical evaluation of next-generation inhibitor targeting a wide spectrum of oncogenic BRAF dimers","authors":"Yoon-Chi Han, Pui Yee Ng, Ryan Schulz, S. Yang, A. Lelo, Luisa Shin, M. O’Connor, I. Jewett, N. Ishiyama, D. Romashko, S. Thakur, A. Salomatov, S. Smith, E. Buck, Christopher Roberts, M. Lucas, Tai-an Lin","doi":"10.1158/1535-7163.targ-21-p229","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p229","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"419 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77776511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p180
Weijia Cai, Mai Q. Nguyen, Nicole A. Wilski, Timothy J. Purwin, Manoela TiagodosSantos, A. Aplin
{"title":"Abstract P180: Genetic screen identifies PDPK1 as a synergistic target to enhancing the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma","authors":"Weijia Cai, Mai Q. Nguyen, Nicole A. Wilski, Timothy J. Purwin, Manoela TiagodosSantos, A. Aplin","doi":"10.1158/1535-7163.targ-21-p180","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p180","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77982675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p142
A. Klippel, Rui Wang, L. Puca, Andrew L. Faber, W. Shen, S. Bhagwat, Kannan R. Karukurichi, Feiyu Zhang, C. Pérez, Ramón Rama, Ana Ramos, Yi Zheng, Z. Bonday, James Thomas, H. Brooks, Lisa J. Kindler, Sarah M. Bogner, Parisa Zolfaghari, M. Ii, S. Callies, B. Mattioni, L. LeBrun, J. Durbin, E. Anderson, Chris Mayne, E. Kesicki, Gabrielle R. Kolakowski, S. Andrews, B. Brandhuber
{"title":"Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor","authors":"A. Klippel, Rui Wang, L. Puca, Andrew L. Faber, W. Shen, S. Bhagwat, Kannan R. Karukurichi, Feiyu Zhang, C. Pérez, Ramón Rama, Ana Ramos, Yi Zheng, Z. Bonday, James Thomas, H. Brooks, Lisa J. Kindler, Sarah M. Bogner, Parisa Zolfaghari, M. Ii, S. Callies, B. Mattioni, L. LeBrun, J. Durbin, E. Anderson, Chris Mayne, E. Kesicki, Gabrielle R. Kolakowski, S. Andrews, B. Brandhuber","doi":"10.1158/1535-7163.targ-21-p142","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p142","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76457811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p140
C. Bellis, S. Chakraborty, Mihlali Mlaza, Bianca Del Bianco Sahm, Paula Rezende Teixeira, L. Costa‐Lotufo, S. Prince
{"title":"Abstract P140: Chromomycin A5, a marine-derived antibiotic, targets the oncogenic TBX2 in breast cancer","authors":"C. Bellis, S. Chakraborty, Mihlali Mlaza, Bianca Del Bianco Sahm, Paula Rezende Teixeira, L. Costa‐Lotufo, S. Prince","doi":"10.1158/1535-7163.targ-21-p140","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p140","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88285496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p078
J. W. Lee, Sundong Kim, C. Yang, B. Burtness
{"title":"Abstract P078: Aurora A kinase inhibition with VIC-1911 overcomes intrinsic and acquired resistance to KRASG12C inhibition in KRAS(G12C)-mutated lung cancer","authors":"J. W. Lee, Sundong Kim, C. Yang, B. Burtness","doi":"10.1158/1535-7163.targ-21-p078","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p078","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"20 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86755969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p125
Jiawan Wang, A. Calizo, K. Pollard, A. Hirbe, C. Pratilas
{"title":"Abstract P125: Combined inhibition of SHP2 and CDK4/6 is active in NF1-associated malignant peripheral nerve sheath tumor","authors":"Jiawan Wang, A. Calizo, K. Pollard, A. Hirbe, C. Pratilas","doi":"10.1158/1535-7163.targ-21-p125","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p125","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"180 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88969314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1158/1535-7163.targ-21-p143
Patrick Connerty, Ernest Moles, Charles E. deBock, Nisitha Jayatilleke, Jenny L. Smith, S. Meshinchi, C. Mayoh, M. Kavallaris, R. Lock
{"title":"Abstract P143: Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for paediatric acute myeloid leukaemia","authors":"Patrick Connerty, Ernest Moles, Charles E. deBock, Nisitha Jayatilleke, Jenny L. Smith, S. Meshinchi, C. Mayoh, M. Kavallaris, R. Lock","doi":"10.1158/1535-7163.targ-21-p143","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p143","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"20 1 Part 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89193213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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