The Journal of Gene Medicine

TFPI2 and NDRG4 gene promoter methylation analysis in peripheral blood mononuclear cells are novel epigenetic noninvasive biomarkers for colorectal cancer diagnosis.

Pub Date : 2020-08-01 DOI: 10.1002/jgm.3189 Hadi Bagheri, Meysam Mosallaei, Bahram Bagherpour, Sharifeh Khosravi, Ahmad Reza Salehi, Rasoul Salehi

Cnidium lactone prevents bone loss in an ovariectomized rat model through the estrogen-α/BMP-2/Smad signaling pathway.

Pub Date : 2020-08-01 DOI: 10.1002/jgm.3198 Zhao Wang, Hong-Wei Bao, You-Jia Xu

A homozygous missense variant in the homeobox domain of the NKX6-2 results in progressive spastic ataxia type 8 associated with lower limb weakness and neurological manifestations.

Pub Date : 2020-08-01 DOI: 10.1002/jgm.3196 Ahmad Almatrafi, Muhammad Umair, Amr Eldardear, Majid Al-Luqmani, Jamil A Hashmi, Alia M Albalawi, Majid Alfadhel, Khushnooda Ramzan, Sulman Basit