M. Hayashi, H. Kawakubo, K. Fukuda, S. Mayanagi, R. Nakamura, K. Suda, Testu Hayashida, N. Wada, Y. Kitagawa
Although chemotherapy is a core treatment for esophageal cancer, some patients develop drug resistance. Gene screening with transposons (i.e. mobile genetic elements) is a novel procedure for identifying chemotherapy‐resistant genes. Transposon insertion can randomly affect nearby gene expression. By identifying the affected genes, candidate genes can be found. The present study aimed to identify cisplatin (CDDP)/5‐fluorouracil (5‐FU)‐resistant genes in in vitro human esophageal squamous cell carcinoma with transposons.
{"title":"THUMP domain containing 2 protein possibly induces resistance to cisplatin and 5‐fluorouracil in in vitro human esophageal squamous cell carcinoma cells as revealed by transposon activation mutagenesis","authors":"M. Hayashi, H. Kawakubo, K. Fukuda, S. Mayanagi, R. Nakamura, K. Suda, Testu Hayashida, N. Wada, Y. Kitagawa","doi":"10.1002/jgm.3135","DOIUrl":"https://doi.org/10.1002/jgm.3135","url":null,"abstract":"Although chemotherapy is a core treatment for esophageal cancer, some patients develop drug resistance. Gene screening with transposons (i.e. mobile genetic elements) is a novel procedure for identifying chemotherapy‐resistant genes. Transposon insertion can randomly affect nearby gene expression. By identifying the affected genes, candidate genes can be found. The present study aimed to identify cisplatin (CDDP)/5‐fluorouracil (5‐FU)‐resistant genes in in vitro human esophageal squamous cell carcinoma with transposons.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132031082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Saravani, Mohsen Rokni, M. Mehrbani, Arian Amirkhosravi, Sanaz Faramarz, I. Fatemi, Mojdeh Esmaeili Tarzi, M. Nematollahi
Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheath destruction. Hypoxia‐inducible factor 1 (HIF‐1) has several roles in cells, such as inducing inflammation and angiogenesis. Recently, several lines of evidence have indicated the role of the hypoxia response and the HIF‐1 signaling pathway in an autoimmune disease such as MS. The present study aimed to evaluate the effects of HIF‐1α gene polymorphisms and vascular endothelial growth factor (VEGF) (as a major target gene of HIF‐1α) gene polymorphism on MS susceptibility.
{"title":"The evaluation of VEGF and HIF‐1α gene polymorphisms and multiple sclerosis susceptibility","authors":"M. Saravani, Mohsen Rokni, M. Mehrbani, Arian Amirkhosravi, Sanaz Faramarz, I. Fatemi, Mojdeh Esmaeili Tarzi, M. Nematollahi","doi":"10.1002/jgm.3132","DOIUrl":"https://doi.org/10.1002/jgm.3132","url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheath destruction. Hypoxia‐inducible factor 1 (HIF‐1) has several roles in cells, such as inducing inflammation and angiogenesis. Recently, several lines of evidence have indicated the role of the hypoxia response and the HIF‐1 signaling pathway in an autoimmune disease such as MS. The present study aimed to evaluate the effects of HIF‐1α gene polymorphisms and vascular endothelial growth factor (VEGF) (as a major target gene of HIF‐1α) gene polymorphism on MS susceptibility.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114627000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shang-Lun Chiang, S. Nithiyanantham, B. Velmurugan, H. Tu, Chien-Hung Lee, Y. Ko
Cigarette smoking in women is raising a public health problem. The X‐linked monoamine oxidase A (MAOA) was considered as a susceptibility gene to substance abuse of tobacco, but the evolutionary effect of MAOA may lead to a positive or negative association between genetic variations and smoking development among study regions.
{"title":"A haplotype‐specific linkage disequilibrium pattern of monoamine oxidase A gene associated with regular smoking in women","authors":"Shang-Lun Chiang, S. Nithiyanantham, B. Velmurugan, H. Tu, Chien-Hung Lee, Y. Ko","doi":"10.1002/jgm.3142","DOIUrl":"https://doi.org/10.1002/jgm.3142","url":null,"abstract":"Cigarette smoking in women is raising a public health problem. The X‐linked monoamine oxidase A (MAOA) was considered as a susceptibility gene to substance abuse of tobacco, but the evolutionary effect of MAOA may lead to a positive or negative association between genetic variations and smoking development among study regions.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130906546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaori Koizumi, H. Nakamura, M. Iijima, T. Matsuzaki, Masaharu Somiya, K. Kumasawa, T. Kimura, S. Kuroda
The uterus is an organ that is directly accessible via the transvaginal route, whereas the drug delivery system and the gene delivery system (GDS) for the uterus are very limited, even in animal models. In the present study, we optimized a bionanocapsule (BNC) comprising a hepatitis B virus envelope L‐protein particle, for which a structurally similar particle has been used as an immunogen of a conventional HB vaccine worldwide for more than 30 years, as a local uterine GDS using a mouse model.
{"title":"In vivo uterine local gene delivery system using TAT‐displaying bionanocapsules","authors":"Kaori Koizumi, H. Nakamura, M. Iijima, T. Matsuzaki, Masaharu Somiya, K. Kumasawa, T. Kimura, S. Kuroda","doi":"10.1002/jgm.3140","DOIUrl":"https://doi.org/10.1002/jgm.3140","url":null,"abstract":"The uterus is an organ that is directly accessible via the transvaginal route, whereas the drug delivery system and the gene delivery system (GDS) for the uterus are very limited, even in animal models. In the present study, we optimized a bionanocapsule (BNC) comprising a hepatitis B virus envelope L‐protein particle, for which a structurally similar particle has been used as an immunogen of a conventional HB vaccine worldwide for more than 30 years, as a local uterine GDS using a mouse model.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130344228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Triple‐negative breast cancer (TNBC) has become a common tumor that harms women's physical and mental health, as characterized by a relatively rapid recurrence and a high incidence of brain metastasis. Research increasingly suggests that microRNAs play key roles in the progress of TNBC. However, the function of miR‐6838‐5p in TNBC has not yet been reported, and requires additional exploration.
三阴性乳腺癌(Triple‐negative breast cancer, TNBC)具有复发相对较快、脑转移发生率高的特点，已成为危害女性身心健康的常见肿瘤。越来越多的研究表明，microrna在TNBC的进展中起着关键作用。然而，miR - 6838 - 5p在TNBC中的功能尚未报道，需要进一步探索。
{"title":"MiR‐6838‐5p suppresses cell metastasis and the EMT process in triple‐negative breast cancer by targeting WNT3A to inhibit the Wnt pathway","authors":"Guozhu Liu, ping wang, Hao Zhang","doi":"10.1002/jgm.3129","DOIUrl":"https://doi.org/10.1002/jgm.3129","url":null,"abstract":"Triple‐negative breast cancer (TNBC) has become a common tumor that harms women's physical and mental health, as characterized by a relatively rapid recurrence and a high incidence of brain metastasis. Research increasingly suggests that microRNAs play key roles in the progress of TNBC. However, the function of miR‐6838‐5p in TNBC has not yet been reported, and requires additional exploration.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122199314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bo Gao, Shuai Hao, Wuguo Tian, Yan Jiang, Shu Zhang, Lingji Guo, Jianjie Zhao, Gang Zhang, Jie Yan, Donglin Luo
In the present study, we investigated the possible tumor suppressive effect of microRNA‐107 (miR‐107) in human breast cancer.
在本研究中，我们研究了microRNA‐107 (miR‐107)在人乳腺癌中可能的肿瘤抑制作用。
{"title":"MicroRNA‐107 is downregulated and having tumor suppressive effect in breast cancer by negatively regulating brain‐derived neurotrophic factor","authors":"Bo Gao, Shuai Hao, Wuguo Tian, Yan Jiang, Shu Zhang, Lingji Guo, Jianjie Zhao, Gang Zhang, Jie Yan, Donglin Luo","doi":"10.1002/jgm.2932","DOIUrl":"https://doi.org/10.1002/jgm.2932","url":null,"abstract":"In the present study, we investigated the possible tumor suppressive effect of microRNA‐107 (miR‐107) in human breast cancer.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126467325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Shariati, H. Khanahmad, Mansoor Salehi, Z. Hejazi, I. Rahimmanesh, Mohammad Amin Tabatabaiefar, M. Modarressi
β‐thalassemia comprises a major group of human genetic disorders involving a decrease in or an end to the normal synthesis of the β‐globin chains of hemoglobin. KLF1 is a key regulatory molecule involved in the γ‐ to β‐globin gene switching process directly inducing the expression of the β‐globin gene and indirectly repressing γ‐globin. The present study aimed to investigate the ability of an engineered CRISPR/Cas9 system with respect to disrupting the KLF1 gene to inhibit the γ‐ to β‐hemoglobin switching process in K562 cells.
{"title":"Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system","authors":"L. Shariati, H. Khanahmad, Mansoor Salehi, Z. Hejazi, I. Rahimmanesh, Mohammad Amin Tabatabaiefar, M. Modarressi","doi":"10.1002/jgm.2928","DOIUrl":"https://doi.org/10.1002/jgm.2928","url":null,"abstract":"β‐thalassemia comprises a major group of human genetic disorders involving a decrease in or an end to the normal synthesis of the β‐globin chains of hemoglobin. KLF1 is a key regulatory molecule involved in the γ‐ to β‐globin gene switching process directly inducing the expression of the β‐globin gene and indirectly repressing γ‐globin. The present study aimed to investigate the ability of an engineered CRISPR/Cas9 system with respect to disrupting the KLF1 gene to inhibit the γ‐ to β‐hemoglobin switching process in K562 cells.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125685028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Jin, Hongxing Zhang, Qi Yang, Lei Li, Yongri Ouyang, Min Yang, Fengjiao Wang, Zhenyuan Wang, Ji Zhang, D. Yuan
The number of heroin addicts is increasing in the world. Both environmental and genetic factors both play critical roles in the process of heroin addiction. We aimed to investigate the associations between single nucleotide polymorphisms (SNPs) in LIN7C, BDNFOS and BDNF genes and drug addiction in the Han Chinese population.
{"title":"The relationship between polymorphisms of BDNFOS and BDNF genes and heroin addiction in the Han Chinese population","authors":"T. Jin, Hongxing Zhang, Qi Yang, Lei Li, Yongri Ouyang, Min Yang, Fengjiao Wang, Zhenyuan Wang, Ji Zhang, D. Yuan","doi":"10.1002/jgm.2927","DOIUrl":"https://doi.org/10.1002/jgm.2927","url":null,"abstract":"The number of heroin addicts is increasing in the world. Both environmental and genetic factors both play critical roles in the process of heroin addiction. We aimed to investigate the associations between single nucleotide polymorphisms (SNPs) in LIN7C, BDNFOS and BDNF genes and drug addiction in the Han Chinese population.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117072562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although herpes simplex virus type 1 (HSV‐1) has outstanding properties for gene delivery vectors and its genome is available in bacterial artificial chromosomes (BACs) for mutagenesis studies, one impediment is the presence of approximately 15.4 kb of DNA sequences that are duplicated in the HSV‐1 genome, complicating vector construction and stability.
{"title":"A haploid HSV‐1 genome platform for vector development: testing of the tetracycline‐responsive switch shows interference by infected cell protein 0","authors":"H. Khalique, Jorge López Marco, F. Lim","doi":"10.1002/jgm.2929","DOIUrl":"https://doi.org/10.1002/jgm.2929","url":null,"abstract":"Although herpes simplex virus type 1 (HSV‐1) has outstanding properties for gene delivery vectors and its genome is available in bacterial artificial chromosomes (BACs) for mutagenesis studies, one impediment is the presence of approximately 15.4 kb of DNA sequences that are duplicated in the HSV‐1 genome, complicating vector construction and stability.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131016799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The original article to which this Erratum refers was published in Journal of Gene Medicine 9: 2007; 779–787.
本勘误所引用的原始文章发表在《基因医学杂志》2007年第9期;779 - 787。
{"title":"Erratum: Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral‐mediated gene transfer Xing Yan, Antonis Voutetakis, Changyu Zheng, Bo Hai, Chunmei Zhang, Bruce J. Baum, Songlin Wang. Journal of Gene Medicine 2007; 9: 779–787","authors":"","doi":"10.1002/jgm.1134","DOIUrl":"https://doi.org/10.1002/jgm.1134","url":null,"abstract":"The original article to which this Erratum refers was published in Journal of Gene Medicine 9: 2007; 779–787.","PeriodicalId":328333,"journal":{"name":"The Journal of Gene Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119944723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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