Regular and Young Investigator Award Abstracts

1089 Local cancer immunotherapy with a mixture of cytokine-encoding mRNAs formulated in a novel lipoplex stimulates potent antitumor immune responses resulting in improved antitumor activity

Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.1089 Marie Bernardo, Timothy R Wagenaar, Hossam Hefesha, Virna Cortez-Retamozo, Mikhail Levit, Isaac Esparza, Ferdia Bates, Kerstin Andrea Heyl, Katalin Kariko, Donald Shaffer, Christian Hotz

455 Establishing an effective xenograft mouse model: replicating human immune cell infiltration in colon adenocarcinoma for enhanced immunotherapy testing

Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0455 Emilie Bayon, Audrey Wetzel, Arije Mersni, Kiave Yune Ho Wang Yin

541 Diabetes and glucose level as metabolic determinants of immune checkpoint inhibitors response in melanoma

Pub Date : 2023-11-01 DOI: 10.1136/jitc-2023-sitc2023.0541 Yu Jen A Jan, Soravis Osataphan, Cho Han Chiang, Kerry Reynolds, Ryan Sullivan