Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1089
Marie Bernardo, Timothy R Wagenaar, Hossam Hefesha, Virna Cortez-Retamozo, Mikhail Levit, Isaac Esparza, Ferdia Bates, Kerstin Andrea Heyl, Katalin Kariko, Donald Shaffer, Christian Hotz
{"title":"1089 Local cancer immunotherapy with a mixture of cytokine-encoding mRNAs formulated in a novel lipoplex stimulates potent antitumor immune responses resulting in improved antitumor activity","authors":"Marie Bernardo, Timothy R Wagenaar, Hossam Hefesha, Virna Cortez-Retamozo, Mikhail Levit, Isaac Esparza, Ferdia Bates, Kerstin Andrea Heyl, Katalin Kariko, Donald Shaffer, Christian Hotz","doi":"10.1136/jitc-2023-sitc2023.1089","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1089","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"4 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0455
Emilie Bayon, Audrey Wetzel, Arije Mersni, Kiave Yune Ho Wang Yin
{"title":"455 Establishing an effective xenograft mouse model: replicating human immune cell infiltration in colon adenocarcinoma for enhanced immunotherapy testing","authors":"Emilie Bayon, Audrey Wetzel, Arije Mersni, Kiave Yune Ho Wang Yin","doi":"10.1136/jitc-2023-sitc2023.0455","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0455","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"4 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0541
Yu Jen A Jan, Soravis Osataphan, Cho Han Chiang, Kerry Reynolds, Ryan Sullivan
{"title":"541 Diabetes and glucose level as metabolic determinants of immune checkpoint inhibitors response in melanoma","authors":"Yu Jen A Jan, Soravis Osataphan, Cho Han Chiang, Kerry Reynolds, Ryan Sullivan","doi":"10.1136/jitc-2023-sitc2023.0541","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0541","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"3 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0835
Emily E Steffke, Taijun Hana, Laila Latifi, Vinnycius Pereira Almeida, James McAuliffe, Amanda Wicki, Laurine Noblecourt, Morgan Coombs, Nargis Malik, Wei Zhang, Meili Zhang, Hua Song, Dionne Davis, Nicole Briceno, Mark Gilbert, Gary Kohanbash, Hideho Okada, Carol Leung, Benoit Van den Eynde, Masaki Terabe
{"title":"835 Heterologous prime boost viral vector vaccination provides protection against intracranial syngeneic murine glioblastoma","authors":"Emily E Steffke, Taijun Hana, Laila Latifi, Vinnycius Pereira Almeida, James McAuliffe, Amanda Wicki, Laurine Noblecourt, Morgan Coombs, Nargis Malik, Wei Zhang, Meili Zhang, Hua Song, Dionne Davis, Nicole Briceno, Mark Gilbert, Gary Kohanbash, Hideho Okada, Carol Leung, Benoit Van den Eynde, Masaki Terabe","doi":"10.1136/jitc-2023-sitc2023.0835","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0550
Assaf Menachem, Zoya Alteber, Gady Cojocaru, Tal Fridman Kfir, Dan Blat, Olga Leiderman, Moran Galperin, Lital Sever, Nadav Cohen, Keren Cohen, Roy Granit, Sandra Vols, Masha Frenkel, Lior Faigenbloom, Liron Soffer, Karin Meyer, Keren Menachem, Hadas Galon Tilleman, Michal Perpinial, Evgeny Tatirovsky, Pierre Ferre, Eran Ophir
{"title":"550 Harnessing natural IL-18 activity through IL-18BP blockade reshapes the tumor microenvironment for potent anti-tumor immune response","authors":"Assaf Menachem, Zoya Alteber, Gady Cojocaru, Tal Fridman Kfir, Dan Blat, Olga Leiderman, Moran Galperin, Lital Sever, Nadav Cohen, Keren Cohen, Roy Granit, Sandra Vols, Masha Frenkel, Lior Faigenbloom, Liron Soffer, Karin Meyer, Keren Menachem, Hadas Galon Tilleman, Michal Perpinial, Evgeny Tatirovsky, Pierre Ferre, Eran Ophir","doi":"10.1136/jitc-2023-sitc2023.0550","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0550","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"71 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.1223
Santosh Narayan, Allison P Drain, Nathaniel Swanson, Nicholas Rouillard, Tyler Warner, Nicole Danek, Ken Gareau, Cheryl Black, James Parsons, Anthony Thomas, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Vince Nguyen, Iqraa Priyata, Sarah Vidyasagar, Joshua Francis, Xingyue He, Patrick J Browne, Rebecca C Lamothe, Meghan D Storlie, Gregory J Cost, Thomas M Schmitt, Philip D Greenberg, Smita S Chandran, Christopher A Klebanoff, Ankit Gupta, Damien Hallet, Gary Shapiro, Kim Nguyen, Loic Vincent
{"title":"1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the<i>TRAC</i>locus outperforms lentiviral-based engineering of T cells","authors":"Santosh Narayan, Allison P Drain, Nathaniel Swanson, Nicholas Rouillard, Tyler Warner, Nicole Danek, Ken Gareau, Cheryl Black, James Parsons, Anthony Thomas, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Vince Nguyen, Iqraa Priyata, Sarah Vidyasagar, Joshua Francis, Xingyue He, Patrick J Browne, Rebecca C Lamothe, Meghan D Storlie, Gregory J Cost, Thomas M Schmitt, Philip D Greenberg, Smita S Chandran, Christopher A Klebanoff, Ankit Gupta, Damien Hallet, Gary Shapiro, Kim Nguyen, Loic Vincent","doi":"10.1136/jitc-2023-sitc2023.1223","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.1223","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"70 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"651 A phase 1, multicenter, open-label, dose-escalation, safety, pharmacodynamic, pharmacokinetic study of Q702 with a cohort expansion at the RP2D in patients with advanced solid tumors","authors":"Devalingam Mahalingam, Angela Alistar, Alain Mita, Jeongjun Kim, Hyunji Ahn, Jinho Choi, Seung-Hee Ryu, Jiye Ahn, Bae Jung Choi, Hwankyu Kang, Yeong-In Yang, Seung-Joo Lee, Borami Jeon, Stefan Proniuk, Kiyean Nam, Anthony El-Khoueiry","doi":"10.1136/jitc-2023-sitc2023.0651","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0651","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"308 1-4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0199
Suhendan Ekmekcioglu, Sungnam Cho, Javier A Gomez, Reham Abdel-Wahab, Salah-Eddine Bentebibel, Noha Abdel-Wahab, Julie M Simon, Jeffrey E Gershenwald, Alexander J Lazar, Jared K Burks, Michael A Davies, Adi Diab
{"title":"199 Quantitative and spatial characteristics of TIL in inflammatory neighborhoods of advanced melanoma tumors","authors":"Suhendan Ekmekcioglu, Sungnam Cho, Javier A Gomez, Reham Abdel-Wahab, Salah-Eddine Bentebibel, Noha Abdel-Wahab, Julie M Simon, Jeffrey E Gershenwald, Alexander J Lazar, Jared K Burks, Michael A Davies, Adi Diab","doi":"10.1136/jitc-2023-sitc2023.0199","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0199","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135215852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0737
Justin C Moser, Mateusz Opyrchal, Ildefonso Rodriguez Rivera, Mehmet A Bilen, Brendan Curti, Igor Puzanov, Kristin Morris, Christopher J Nirschl, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K Subramanian, Sameer S Chopra, Randi Isaacs
{"title":"737 A phase 1/1b study of the tumor-activated IL-2 prodrug WTX-124 alone or in combination with pembrolizumab in patients with immunotherapy-sensitive locally advanced or metastatic solid tumors","authors":"Justin C Moser, Mateusz Opyrchal, Ildefonso Rodriguez Rivera, Mehmet A Bilen, Brendan Curti, Igor Puzanov, Kristin Morris, Christopher J Nirschl, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K Subramanian, Sameer S Chopra, Randi Isaacs","doi":"10.1136/jitc-2023-sitc2023.0737","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0737","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"19 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1136/jitc-2023-sitc2023.0679
Alan L Ho, Alexander T Pearson, Siqing Fu, Marshall R Posner, Douglas Adkins, Lisle Nabell, Jiaxin Niu, Debra L Richardson, Rom S Leidner, Ki Chung, Douglas Laux, Jorge Nieva, Stuart Wong, Katerin Rojas, Ari J Rosenberg, Minh Phan, Trisha Kaufmann, Christopher Plescia, Xiaoping Qing, Corinne Iacobucci, Ilian Tchakov, Kia Katchar, Klaus Orlinger, Katia Schlienger, David G Pfister
{"title":"679 Characterization of tumor specific CD8+ T cell responses in patients with recurrent/metastatic HPV16-positive head and neck cancer receiving HB-200 monotherapy as second or later line treatment in a phase 1 study","authors":"Alan L Ho, Alexander T Pearson, Siqing Fu, Marshall R Posner, Douglas Adkins, Lisle Nabell, Jiaxin Niu, Debra L Richardson, Rom S Leidner, Ki Chung, Douglas Laux, Jorge Nieva, Stuart Wong, Katerin Rojas, Ari J Rosenberg, Minh Phan, Trisha Kaufmann, Christopher Plescia, Xiaoping Qing, Corinne Iacobucci, Ilian Tchakov, Kia Katchar, Klaus Orlinger, Katia Schlienger, David G Pfister","doi":"10.1136/jitc-2023-sitc2023.0679","DOIUrl":"https://doi.org/10.1136/jitc-2023-sitc2023.0679","url":null,"abstract":"","PeriodicalId":500964,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"17 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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