The Journal of Clinical Investigation

Non-classical action of Ku70 promotes Treg suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma.

Pub Date : 2024-10-24 DOI: 10.1172/jci178079 Qianru Huang,Na Tian,Jianfeng Zhang,Shiyang Song,Hao Cheng,Xinnan Liu,Wenle Zhang,Youqiong Ye,Yanhua Du,Xueyu Dai,Rui Liang,Dan Li,Sheng-Ming Dai,Chuan Wang,Zhi Chen,Qianjun Zhou,Bin Li

Frameshift mutation spectra overlap between constitutional mismatch repair deficiency tumors and Lynch syndrome tumors.

Pub Date : 2024-10-22 DOI: 10.1172/jci185999 Yurong Song,Ryan N Baugher,Todd B Young,Brandon Somerville,Yuriko Mori,Ligia A Pinto,Kim E Nichols,Robert H Shoemaker

MOGAT3-Mediated DAG Accumulation Drives Acquired Resistance to Anti-BRAF/EGFR Therapy in BRAFV600E-Mutant Metastatic Colorectal Cancer.

Pub Date : 2024-10-22 DOI: 10.1172/jci182217 Jiawei Wang,Huogang Wang,Wei Zhou,Xin Luo,Huijuan Wang,Qing Meng,Jiaxin Chen,Xiaoyu Chen,Yinqiang Liu,David W Chan,Zhenyu Ju,Zhangfa Song