The Journal of Clinical Investigation

Vascular smooth muscle cell-derived KIF13B protects against atherosclerosis: evidence from humans and mice.

Pub Date : 2026-01-29 DOI: 10.1172/jci194175 Guolin Miao,Yufei Han,Jingxuan Chen,Yiran Liu,Ge Zhang,Shaotong Pei,Yinqi Zhao,Yitong Xu,Liwen Zheng,Zhaoling Li,Xiangru Liu,Sijing Shi,Xuya Kang,Yahan Liu,Ling Zhang,Wei Huang,Yuhui Wang,Junnan Tang,Erdan Dong,Xunde Xian

MAP4K2 suppresses antitumor immunity in a pancreatic cancer model by promoting Treg differentiation.

Pub Date : 2026-01-29 DOI: 10.1172/jci196379 Huai-Chia Chuang,Chia-Wen Wang,Chia-Hsin Hsueh,Yu-Zhi Xiao,Ching-Yi Tsai,Pu-Ming Hsu,Evelyn L Tan,Hsien-Yi Chiu,Tse-Hua Tan

Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound.

Pub Date : 2026-01-29 DOI: 10.1172/jci198294 Were R Omange,Benjamin D Varco-Merth,Omo Fadeyi,Alejandra Marenco,Hiroshi Takata,Derick M Duell,William D Goodwin,Paula Armitage,Christine M Fennessey,Emek Kose,Taina T Immonen,Ewelina Kosmider,William J Bosche,Randy Fast,Chris Homick,Kelli Oswald,Rebecca Shoemaker,Rachele Bochart,Rhonda MacAllister,Caralyn S Labriola,Jeremy V Smedley,Michael K Axthelm,Paul T Edlefsen,Brandon F Keele,Jeffrey D Lifson,Janina Gergen,Benjamin Petsch,Susanne Rauch,Louis J Picker,Afam A Okoye