Discovery immunology

Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells.

Pub Date : 2025-11-28 DOI: 10.1093/discim/kyaf016 Farjana Islam, Scott Layzell, Ines Boal-Carvalho, Benedict Seddon

Vaccination of calves with Bacille Calmette Guerin increased the frequency but did not affect aggregation or clustering of natural killer cells in draining lymph nodes.

Pub Date : 2025-11-13 DOI: 10.1093/discim/kyaf017 Jayne C Hope, Sarah Ho, Clara Zifko, Carly A Hamilton, Darren J Shaw

Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations.

Pub Date : 2025-11-12 DOI: 10.1093/discim/kyaf018 Alexander W Hardgrave, Megan Dooley, Ivy Maminimini, Adura Faniyi, Antonia Christodoulidou, Yasmine Alshammari, Helen J March, Riccardo V D'Elia, John J Worthington