Systems biology

Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour.

Pub Date : 2006-11-01 DOI: 10.1049/ip-syb:20050065 B B Aldridge, G Haller, P K Sorger, D A Lauffenburger

Decreased internalisation of erbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib.

Pub Date : 2006-11-01 DOI: 10.1049/ip-syb:20050108 B S Hendriks, G J Griffiths, R Benson, D Kenyon, M Lazzara, J Swinton, S Beck, M Hickinson, J M Beusmans, D Lauffenburger, D de Graaf

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.

Pub Date : 2006-11-01 DOI: 10.1049/ip-syb:20050067 U Klingmüller, A Bauer, S Bohl, P J Nickel, K Breitkopf, S Dooley, S Zellmer, C Kern, I Merfort, T Sparna, J Donauer, G Walz, M Geyer, C Kreutz, M Hermes, F Götschel, A Hecht, D Walter, L Egger, K Neubert, C Borner, M Brulport, W Schormann, C Sauer, F Baumann, R Preiss, S MacNelly, P Godoy, E Wiercinska, L Ciuclan, J Edelmann, K Zeilinger, M Heinrich, U M Zanger, R Gebhardt, T Maiwald, R Heinrich, J Timmer, F von Weizsäcker, J G Hengstler