Fat mass index and airway hyperresponsiveness in Korean adults.

IF 2.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Postgraduate Medicine Pub Date : 2023-06-01 DOI:10.1080/00325481.2023.2188000
Ji-Su Shim, Sun-Sin Kim, So-Hee Lee, Min-Hye Kim, Young-Joo Cho, Heung-Woo Park
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Abstract

Objective: Airway hyperresponsiveness (AHR) is associated with asthma and obesity, which is defined as a high body mass index. Body mass mainly comprises fat mass (FM) and muscle mass (MM), which are independent of each other. We investigated the effect of changes in FM over time on the development of asymptomatic AHR in adults.

Methods: This long-term longitudinal study included adults who were underwent health checkups at the Seoul National University Hospital Gangnam Center. The participants underwent two methacholine bronchial provocation tests with a follow-up period (between the first and second tests) of more than 3 years and bioelectrical impedance analysis (BIA) at all visits. FM index (FMI; FM normalized for height) and MM index (MMI; MM normalized for height) were calculated using BIA.

Results: The study included 328 adult participants (61 women and 267 men). The mean number of BIA measurements was 6.96 and the follow-up duration was 6.69 years. In total, 13 participants showed a positive conversion of AHR. Multivariate analysis indicated that a high rate of change in FMI ([g/m2]/year), not MMI, was significantly associated with the risk of AHR development (P = 0.037) after adjustment for age, sex, smoking status, and FEV1 predicted.

Conclusion: A rapid gain of FM over time may be a risk factor for developing AHR in adults. Prospective studies are needed to confirm our results and evaluate the role of FM reduction in preventing AHR development in obese adults.

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韩国成人的脂肪质量指数与气道高反应性。
目的:气道高反应性(AHR)与哮喘和肥胖相关,其定义为高体重指数。身体质量主要包括脂肪质量(FM)和肌肉质量(MM),两者是相互独立的。我们调查了FM随时间变化对成人无症状AHR发展的影响。方法:这项长期的纵向研究包括在首尔国立大学医院江南中心接受健康检查的成年人。参与者接受了两次甲胆碱支气管激发试验,随访期(第一次和第二次试验之间)超过3年,并在所有就诊时进行生物电阻抗分析(BIA)。调频指数(FMI;FM归一化高度)和MM指数(MMI;采用BIA计算高度归一化MM。结果:该研究包括328名成年参与者(61名女性和267名男性)。平均BIA测量次数为6.96次,随访时间为6.69年。共有13名参与者表现出积极的AHR转换。多因素分析表明,在调整年龄、性别、吸烟状况和FEV1预测后,FMI的高变化率([g/m2]/年)与AHR发展风险显著相关(P = 0.037),而非MMI。结论:随着时间的推移,FM的快速增加可能是成人发生AHR的危险因素。需要前瞻性研究来证实我们的结果,并评估减少FM在预防肥胖成人AHR发展中的作用。
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来源期刊
Postgraduate Medicine
Postgraduate Medicine 医学-医学:内科
CiteScore
6.10
自引率
2.40%
发文量
110
审稿时长
6-12 weeks
期刊介绍: Postgraduate Medicine is a rapid peer-reviewed medical journal published for physicians. Tracing its roots back to 1916,  Postgraduate Medicine  was established by Charles Mayo, MD, as a peer-to-peer method of communicating the latest research to aid physicians when making treatment decisions, and it maintains that aim to this day. In addition to its core subscriber base, Postgraduate Medicine is distributed to hundreds of US-based physicians within internal medicine and family practice.
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