Katherine Terence, Olivia Cundy, Salomey Kellett, Andrew D Dick, Jugnoo Rahi, Ameenat Lola Solebo
{"title":"Limited Utility of Keratic Precipitate Morphology as an Indicator of Underlying Diagnosis in Ocular Inflammation.","authors":"Katherine Terence, Olivia Cundy, Salomey Kellett, Andrew D Dick, Jugnoo Rahi, Ameenat Lola Solebo","doi":"10.1080/09273948.2023.2242946","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to establish the degree of consensus among clinicians on descriptors of KP morphology.</p><p><strong>Methods: </strong>A web-based exercise in which respondents associated KP descriptors, as identified through a scoping review of the published literature, to images from different disorders. Inter-observer agreement was assessed using the Krippendorff kappa alpha metric.</p><p><strong>Results: </strong>Of the 76 descriptive terms identified by the scoping review, the most used included \"mutton-fat\" (<i>n</i> = 93 articles, 36%), \"fine/dust\" (<i>n</i> = 76, 29%), \"stellate\" (<i>n</i> = 40, 15%), \"large\" (<i>n</i> = 33, 12%), and \"medium\" (<i>n</i> = 33, 12%). The survey of specialists (<i>n</i> = 26) identified inter-observer agreement for these descriptors to be poor (\"stellate,\" kappa: 0.15, 95% confidence interval 0.13-0.17), limited (\"medium\": 0.27, 95% CI 0.25-0.29; \"dust/fine\": 0.36, 95% CI 0.34-0.37), or moderate (\"mutton fat\": 0.40, 95% CI 0.36-0.43; \"large\": 0.43, 95% CI 0.39-0.46).</p><p><strong>Conclusion: </strong>The clinical utility of KP morphology as an indicator of disease classification is limited by low inter-observer agreement.</p>","PeriodicalId":19406,"journal":{"name":"Ocular Immunology and Inflammation","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ocular Immunology and Inflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09273948.2023.2242946","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/14 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: We aimed to establish the degree of consensus among clinicians on descriptors of KP morphology.
Methods: A web-based exercise in which respondents associated KP descriptors, as identified through a scoping review of the published literature, to images from different disorders. Inter-observer agreement was assessed using the Krippendorff kappa alpha metric.
Results: Of the 76 descriptive terms identified by the scoping review, the most used included "mutton-fat" (n = 93 articles, 36%), "fine/dust" (n = 76, 29%), "stellate" (n = 40, 15%), "large" (n = 33, 12%), and "medium" (n = 33, 12%). The survey of specialists (n = 26) identified inter-observer agreement for these descriptors to be poor ("stellate," kappa: 0.15, 95% confidence interval 0.13-0.17), limited ("medium": 0.27, 95% CI 0.25-0.29; "dust/fine": 0.36, 95% CI 0.34-0.37), or moderate ("mutton fat": 0.40, 95% CI 0.36-0.43; "large": 0.43, 95% CI 0.39-0.46).
Conclusion: The clinical utility of KP morphology as an indicator of disease classification is limited by low inter-observer agreement.
期刊介绍：
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
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