The Nocebo Effect.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-16 DOI:10.1146/annurev-pharmtox-022723-112425
Luana Colloca
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Abstract

Adverse nocebo responses can cause harm to patients and interfere with treatment adherence and effects in both clinic practice and clinical trials. Nocebo responses refer to negative outcomes to active medical treatments in clinical trials or practice that cannot be explained by the treatment's pharmacologic effects. Negative expectancies and nocebo effects are less known than placebo responses. Nocebo effects can be triggered by verbal suggestions, prior negative experiences, observation of others experiencing negative outcomes, and other contextual and environmental factors. As research advances over the years, mechanistic knowledge is accumulating on the neurobiological mechanisms of nocebo effects. This review summarizes studies on different facets of nocebo effects and responses and discusses clinical implications, ethical considerations, and future directions.

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恐慌效应
在临床实践和临床试验中,不良的前兆反应会对患者造成伤害,并影响治疗的依从性和效果。安慰剂反应是指在临床试验或实践中,积极的医学治疗产生了无法用治疗的药理作用来解释的负面结果。与安慰剂反应相比,消极预期和安慰剂效应鲜为人知。言语暗示、先前的负面经历、观察到他人经历负面结果以及其他背景和环境因素都可能引发安慰剂效应。随着多年来研究的进展,有关安慰剂效应神经生物学机制的知识也在不断积累。本综述总结了有关预兆效应和反应不同方面的研究,并讨论了其临床意义、伦理考虑和未来发展方向。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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