Intermittent vs. continuous swimming training on adipokines and pro-inflammatory cytokines in metabolic syndrome experimental model.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-08-17 eCollection Date: 2023-09-01 DOI:10.1515/hmbci-2022-0004

Shila Nayebifar, Hossein Nakhaei, Zohreh Borhani Kakhki, Elham Ghasemi

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Abstract

Objectives: In this study, metabolic syndrome-affected rats were studied to examine how intermittent and continuous swimming training influenced adipokines and pro-inflammatory cytokines.

Methods: Forty-eight male Wistar rats were randomized in this experimental study into four groups (n=8), including normal control (NC), metabolic syndrome (MS), continuous swimming training with metabolic syndrome (CT-MS: load 0-3% body mass, 5 d/wk, for 8 weeks), and intermittent swimming training with metabolic syndrome (IT-MS: load 5-16% body mass, 5 d/wk, for 8 weeks). The serum levels of metrnl, adipolin, irisin, leptin, TNF-α, and IL-6 were measured using the ELISA test.

Results: The IT-MS and NC groups exhibited significantly lower leptin concentrations than the CT-MS group (p=0.001). The irisin, meteorin, and adipolin serum levels increased significantly in CT-MS and IT relative to the NC and CT-MS groups (p=0.001), with the changes being more pronounced in the IT group (p=0.05). TNF-α and IL-6 were inclined in the CT-MS group compared with the other three groups (p=0.001), while IL-6 was increased in the IT group (p=0.024).

Conclusions: Intermittent swimming is more effective than continuous swimming training in improving adipokines in rats with metabolic syndrome.

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代谢综合征实验模型中脂肪因子和促炎细胞因子的间歇与连续游泳训练。

目的：在本研究中，对代谢综合征影响的大鼠进行了研究，以了解间歇性和连续游泳训练如何影响脂肪因子和促炎细胞因子。方法：48只雄性Wistar大鼠随机分为4组（n=8），包括正常对照组（NC）、代谢综合征组（MS）、伴有代谢综合征的连续游泳训练组（CT-MS：负荷0-3%体重，5 d/周，持续8周）和伴有代谢综合症的间歇游泳训练组。采用ELISA法测定血清metrnl、阿脂蛋白、鸢尾素、瘦素、TNF-α和IL-6水平。结果：IT-MS和NC组的瘦素浓度显著低于CT-MS组（p=0.001）。与NC和CT-MS相比，CT-MS和IT组的鸢尾素、陨星蛋白和脂肪蛋白血清水平显著升高（p=0.000），与其他三组相比，CT-MS组TNF-α和IL-6呈下降趋势（p=0.001），而IT组IL-6升高（p=0.024）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.