Impact of Nanotechnology on Differentiation and Augmentation of Stem Cells for Liver Therapy.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2023-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2023042400

Ifrah Anwar, Usman Ali Ashfaq

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Abstract

The liver is one of the crucial organs of the body that performs hundreds of chemical reactions needed by the body to survive. It is also the largest gland of the body. The liver has multiple functions, including the synthesis of chemicals, metabolism of nutrients, and removal of toxins. It also acts as a storage unit. The liver has a unique ability to regenerate itself, but it can lead to permanent damage if the injury is beyond recovery. The only possible treatment of severe liver damage is liver transplant which is a costly procedure and has several other drawbacks. Therefore, attention has been shifted towards the use of stem cells that have shown the ability to differentiate into hepatocytes. Among the numerous kinds of stem cells (SCs), the mesenchymal stem cells (MSCs) are the most famous. Various studies suggest that an MSC transplant can repair liver function, improve the signs and symptoms, and increase the chances of survival. This review discusses the impact of combining stem cell therapy with nanotechnology. By integrating stem cell science and nanotechnology, the information about stem cell differentiation and regulation will increase, resulting in a better comprehension of stem cell-based treatment strategies. The augmentation of SCs with nanoparticles has been shown to boost the effect of stem cell-based therapy. Also, the function of green nanoparticles in liver therapies is discussed.

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纳米技术对肝治疗干细胞分化和增强的影响。

肝脏是人体至关重要的器官之一，它执行人体生存所需的数百种化学反应。它也是人体最大的腺体。肝脏有多种功能，包括化学物质的合成、营养物质的代谢和毒素的排除。它还可以作为存储单元。肝脏具有独特的自我再生能力，但如果损伤无法恢复，它可能导致永久性损伤。严重肝损伤的唯一可能的治疗方法是肝移植，这是一个昂贵的过程，并且有几个其他的缺点。因此，人们的注意力已经转移到干细胞的使用上，这些干细胞已经显示出分化为肝细胞的能力。在种类繁多的干细胞(SCs)中，以间充质干细胞(MSCs)最为著名。各种研究表明，MSC移植可以修复肝功能，改善体征和症状，并增加生存机会。本文综述了将干细胞治疗与纳米技术相结合的影响。通过整合干细胞科学和纳米技术，关于干细胞分化和调控的信息将会增加，从而更好地理解基于干细胞的治疗策略。纳米颗粒增强SCs已被证明可以提高干细胞治疗的效果。此外，还讨论了绿色纳米颗粒在肝脏治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.