{"title":"Determination of salicylic acid content in pharmaceuticals using chitosan@Fe<sub>3</sub>O<sub>4</sub>/CPE electrode detected by SWV technique.","authors":"Sudarut Pitakrut, Phetlada Sanchayanukun, Sasithorn Muncharoen","doi":"10.5599/admet.1682","DOIUrl":null,"url":null,"abstract":"<p><p>Chitosan-coated magnetite nanoparticles (Chitosan@Fe<sub>3</sub>O<sub>4</sub>) were used to modify the carbon paste electrode (Chitosan@Fe<sub>3</sub>O<sub>4</sub>/CPE) to enhance sensitivity for salicylic acid (SA) analysis using square wave voltammetry (SWV). The performance and behaviour of the purposed electrodes were investigated using cyclic voltammetry (CV). The results showed that the mixed behaviour process was observed. Furthermore, parameters affecting SWV were also studied. It was discovered that the optimum conditions were a two-linearity range of SA determination, 1-100 and 100-400 μM. The limit of detection (LOD) and the limit of quantitation (LOQ) for SA are 0.57 μM and 0.90 μM, respectively. The proposed electrodes were successfully used to determine SA in applications employing pharmaceutical samples.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262223/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ADMET and DMPK","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5599/admet.1682","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Chitosan-coated magnetite nanoparticles (Chitosan@Fe3O4) were used to modify the carbon paste electrode (Chitosan@Fe3O4/CPE) to enhance sensitivity for salicylic acid (SA) analysis using square wave voltammetry (SWV). The performance and behaviour of the purposed electrodes were investigated using cyclic voltammetry (CV). The results showed that the mixed behaviour process was observed. Furthermore, parameters affecting SWV were also studied. It was discovered that the optimum conditions were a two-linearity range of SA determination, 1-100 and 100-400 μM. The limit of detection (LOD) and the limit of quantitation (LOQ) for SA are 0.57 μM and 0.90 μM, respectively. The proposed electrodes were successfully used to determine SA in applications employing pharmaceutical samples.
期刊介绍：
ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study
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