Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition.

Journal of the National Cancer Institute. Monographs Pub Date : 2023-05-04 DOI:10.1093/jncimonographs/lgad010

Sarah A Purcell, Dieuwertje E Kok, Tyler Ketterl, Miriam B Garcia, Lenat Joffe, Justin C Brown, Christina M Dieli-Conwright, Grant R Williams

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Abstract

Energy balance accounts for an individual's energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual's drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer.

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癌症治疗药物的药代动力学与能量平衡：饮食摄入、能量消耗和身体组成的作用。

能量平衡是指一个人的能量摄入、消耗和储存。能量平衡的每个方面都对癌症治疗的药代动力学有影响，可能会影响个体的药物暴露，进而影响药物的耐受性和疗效。然而，人们尚未完全了解饮食、体力活动和身体成分对药物吸收、代谢、分布和排泄的综合影响。本综述研究了有关能量平衡的现有文献，特别是膳食摄入和营养状况、体力活动和能量消耗以及身体成分对癌症治疗药物药代动力学的作用。由于能量平衡和药代动力学因素会受到与年龄相关的代谢状态和合并症的影响，本综述还探讨了与年龄相关的身体成分和生理变化对儿童和老年癌症患者药代动力学的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the National Cancer Institute. Monographs

CiteScore

6.30

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0.00%

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