Preussiate, a new urease inhibitory chalcone from Dioscorea preussii Pax.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-01-01 Epub Date: 2023-08-21 DOI:10.1080/14786419.2023.2248350

Muhammad Shaiq Ali, Seerat Iqbal, Mehreen Lateef, Ngoupayo Joseph

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Abstract

The phytochemical investigation of the aqueous methanolic extract of the aerial parts of Dioscorea preussii, led to the isolation of a new chalcone preussiate (1) along with 10 other compounds including xanthomicrol (2), cholestan-3-one (3), arjunolic acid (4), tormentic acid (5), ursolic acid (6), betulin (7), lupeol (8), p-hydroxybenzoic acid (9), isovanillin (10) and vanillic acid (11), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectroscopy. All the isolates were subjected to the biological screening but only showed antioxidant and urease inhibitory properties. The compounds 1,8 and 11 displayed the most potent urease inhibitory properties with IC₅₀ values, 22.4_, 33.3 and 35.7 µM, respectively, while 3 was moderately active. The compound 11 showed potent antioxidant activity among all the tested isolates with an IC₅₀ value of 45.3 µM.

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从薯蓣中提取的一种新的脲酶抑制查尔酮。

通过对薯蓣地上部甲醇水萃取物的植物化学研究，首次从该植物中分离到新的查尔酮酸酯(1)和另外10个化合物，包括黄酮醇(2)、胆甾醇-3- 1(3)、arjunolic酸(4)、拷问酸(5)、熊果酸(6)、白桦素(7)、芦皮醇(8)、对羟基苯甲酸(9)、异香兰素(10)和香草酸(11)。通过二维核磁共振波谱等光谱技术确定了它们的结构。所有分离物均经过生物筛选，但仅表现出抗氧化和抑制脲酶的特性。其中化合物1、8和11的IC50值分别为22.4、33.3和35.7µM，抑制脲酶活性最强，化合物3的IC50值为中等。化合物11在所有被试菌株中表现出较强的抗氧化活性，IC50值为45.3µM。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.