Pub Date : 2025-02-17DOI: 10.1080/14786419.2025.2465605
Aline Coqueiro, Vinicius Galvão Wakui, Alan C Pilon, Nathália S Castilho, Eliângela C C Costa, Afif F Monteiro, Charlene S Dos Anjos, Luis Fernando Leandro, Carlos Henrique Gomes Martins, Vanessa G Pasqualotto Severino
Kielmeyera coriacea Mart., native to Brazilian Cerrado, is traditionally used in folk medicine. The MIC against bacteria and yeasts was determined for the ethanolic extracts of roots, outer bark, leaves, and fruits. A dereplication strategy via HPLC-ESI-HRMS/MS and GNPS was used to identify known compounds and highlight potential compounds responsible for the activities. The root extract exhibited the most promising activity against a range of bacteria and fungi. This extract was selected for further fractionation, yielding n-hexane, ethyl acetate, and hydroalcoholic fractions. These were evaluated against the same microbial strains. Subsequent chromatographic analysis and bioactivity tests identified two highly active subfractions from the n-hexane and hydroalcoholic fractions. Detailed analysis using standards and databases (GNPS and Scifinder) led to the annotation of three xanthones (kielcorin, and its hydroxy- and methoxy- derivatives), three glycosylated flavonoids, and two acylphoroglucinol derivatives (garcinielliptone D e A).
{"title":"Integrative dereplication and molecular networking reveal potential antimicrobial agents in <i>Kielmeyera coriacea</i> Mart.","authors":"Aline Coqueiro, Vinicius Galvão Wakui, Alan C Pilon, Nathália S Castilho, Eliângela C C Costa, Afif F Monteiro, Charlene S Dos Anjos, Luis Fernando Leandro, Carlos Henrique Gomes Martins, Vanessa G Pasqualotto Severino","doi":"10.1080/14786419.2025.2465605","DOIUrl":"https://doi.org/10.1080/14786419.2025.2465605","url":null,"abstract":"<p><p><i>Kielmeyera coriacea</i> Mart., native to Brazilian Cerrado, is traditionally used in folk medicine. The MIC against bacteria and yeasts was determined for the ethanolic extracts of roots, outer bark, leaves, and fruits. A dereplication strategy <i>via</i> HPLC-ESI-HRMS/MS and GNPS was used to identify known compounds and highlight potential compounds responsible for the activities. The root extract exhibited the most promising activity against a range of bacteria and fungi. This extract was selected for further fractionation, yielding <i>n</i>-hexane, ethyl acetate, and hydroalcoholic fractions. These were evaluated against the same microbial strains. Subsequent chromatographic analysis and bioactivity tests identified two highly active subfractions from the <i>n</i>-hexane and hydroalcoholic fractions. Detailed analysis using standards and databases (GNPS and Scifinder) led to the annotation of three xanthones (kielcorin, and its hydroxy- and methoxy- derivatives), three glycosylated flavonoids, and two acylphoroglucinol derivatives (garcinielliptone D e A).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Argan oil is widely used as an active ingredient of dermo-cosmetic products. Its high demand has led to an increase adulteration with varying amounts of inexpensive herbal oils. The quality control of argan oil is one of the most important issues for pharmaceutical companies. In this study,1H-NMR-based metabolomics study was used as a fast and non-destructive technique to detect adulteration. Argan seeds and oil were purchased from pharmacies and stores. The results showed that pure argan oil doesn't contain α-linolenic acid, while it is present in varying amounts in most herbal oils. A number of argan oils that were purchased from the market or pharmacies, despite the manufacturer's claim that the argan oil is 100% pure with no additives in the final product, had impurities especially in aromatic regions. This is the first attempt to demonstrate that the 1H-NMR-based metabolomics study can successfully apply to detect argan oil adulteration.
{"title":"<sup>1</sup>H NMR-based metabolomics study of the lipid profile of argan oil and investigation of possible adulterations in the market of this valuable herbal oil.","authors":"Maede Hasanpour, Nazanin Mohammadpour, Mahnaz Khanavi, Satar Saberi, Tugba Ercetin, Reza Abdollahzadeh, Mehrdad Iranshahi","doi":"10.1080/14786419.2025.2463702","DOIUrl":"https://doi.org/10.1080/14786419.2025.2463702","url":null,"abstract":"<p><p>Argan oil is widely used as an active ingredient of dermo-cosmetic products. Its high demand has led to an increase adulteration with varying amounts of inexpensive herbal oils. The quality control of argan oil is one of the most important issues for pharmaceutical companies. In this study,<sup>1</sup>H-NMR-based metabolomics study was used as a fast and non-destructive technique to detect adulteration. Argan seeds and oil were purchased from pharmacies and stores. The results showed that pure argan oil doesn't contain α-linolenic acid, while it is present in varying amounts in most herbal oils. A number of argan oils that were purchased from the market or pharmacies, despite the manufacturer's claim that the argan oil is 100% pure with no additives in the final product, had impurities especially in aromatic regions. This is the first attempt to demonstrate that the <sup>1</sup>H-NMR-based metabolomics study can successfully apply to detect argan oil adulteration.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A hemisynthesis ‘in situ’ reaction of (thio)barbituric acids with an α,β-unsaturated aldehyde using perillaldehyde from Ammodaucus leucotrichus essential oil, afforded chromeno-pyrimidine derivatives B-1 and B-2. The reaction was carried out in water and water/ethanol medium without a catalyst. The obtained pyrimidines were identified by their spectral 1H,13C, Dept-135, HMBC, HSQC, COSY, and NOESY 2D. The antioxidant activity of both compounds was evaluated using different in vitro methods (DPPH, ABTS, and CUPRAC). The hemisynthesized molecules exhibited a bacteriostatic effect against ten tested gram (+) and gram (–) strains. According to the molecular docking analysis, B-1 showed lower binding energies compared to B-2 against (PDB: 1HD2) and (PDB: 1KZN) targets, which is in agreement with the ABTS and E. Coli assays. Furthermore, a probable promising anti-HIV activity was noticed against reverse transcriptase (PDB: 2RKI), a key enzyme for HIV replication. The ADME properties calculations showed no Lipinski’s rule violation for both compounds.
{"title":"Facile green in situ hemisynthesis of new chiral chromeno-pyrimidine derivatives: antibacterial, antioxidant activities and molecular docking study","authors":"Ramzi Maadadi , Abbes Benmerache , Rafik Menacer , Borhane E.C Ziani , Zahia Kabouche , Liza Saher , Khaldoun Bachari , Dominique Harakat","doi":"10.1080/14786419.2023.2290148","DOIUrl":"10.1080/14786419.2023.2290148","url":null,"abstract":"<div><div>A hemisynthesis ‘<em>in situ</em>’ reaction of (thio)barbituric acids with an α,β-unsaturated aldehyde using perillaldehyde from <em>Ammodaucus leucotrichus</em> essential oil, afforded chromeno-pyrimidine derivatives <strong>B-1</strong> and <strong>B-2</strong>. The reaction was carried out in water and water/ethanol medium without a catalyst. The obtained pyrimidines were identified by their spectral <sup>1</sup>H,<sup>13</sup>C, Dept-135, HMBC, HSQC, COSY, and NOESY 2D. The antioxidant activity of both compounds was evaluated using different <em>in vitro</em> methods (DPPH, ABTS, and CUPRAC). The hemisynthesized molecules exhibited a bacteriostatic effect against ten tested gram (+) and gram (–) strains. According to the molecular docking analysis, <strong>B-1</strong> showed lower binding energies compared to <strong>B-2</strong> against (PDB: 1HD2) and (PDB: 1KZN) targets, which is in agreement with the ABTS and <em>E. Coli</em> assays. Furthermore, a probable promising anti-HIV activity was noticed against reverse transcriptase (PDB: 2RKI), a key enzyme for HIV replication. The ADME properties calculations showed no Lipinski’s rule violation for both compounds.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 758-768"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138569622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2287177
Jianbin Wang , Rongxin Liu , Hao Chen , Anqi Chen , Li Chen
Ent-kaurane diterpenoids were studied as a biologically active ingredient group of Sigesbeckia pubescens (Makino) Makino. Here, five known ent-kaurane diterpenoids were isolated and identified, named ent-16β,17-dihydroxy-kauran-19-oic acid (1), ent-16β,17-dihydroxy-kauran-19-oate (2), ent-18-acetoxy-17-hydroxykauran-19-oic acid (3), ent-16β,17,18-trihydroxy-kauran-19 -oic acid (4), and ent-17-hydroxy-kauran-16βH-19-oic acid (5). Their inhibitory effects of these compounds on MDA-MB-231 breast cancer migration were firstly tested in a chemotaxis invasion assay. Among them, compound 1 (DKA) showed superior inhibitory activities with IC50 value of 1.96 µM. Then, a wound healing assay and BALB/c nude mice were used for further studying the inhibitory activity of DKA on MDA-MB-231 breast cancer migration in vitro and in vivo, respectively. The wound healing assay showed that DKA (1, 5, and 25 μM) can significantly inhibit cell migration and the mouse model of lung metastasis showed that DKA (2.5, 5, and 10 mg/kg) could strongly suppress the lung metastasis of MDA-MB-231 breast cancer cells.
对正戊烷二萜进行了生物活性研究。本研究分离鉴定了5种已知的对kauran二萜类化合物，分别命名为:t-16β、17-二羟基kauran-19-oic酸(1)、t-16β、17-二羟基kauran-19-oic酸(2)、t-18-乙酰氧基-17-羟基kauran-19-oic酸(3)、t-16β、17,18-三羟基kauran-19-oic酸(4)和t-17-羟基kauran-16 - β h -19-oic酸(5)。通过趋化性侵袭实验，首次检测了这些化合物对MDA-MB-231乳腺癌迁移的抑制作用。其中化合物1 (DKA)的IC50值为1.96µM，具有较强的抑制活性。通过伤口愈合实验和BALB/c裸鼠实验，进一步研究DKA对MDA-MB-231乳腺癌迁移的体外和体内抑制作用。伤口愈合实验显示，DKA(1、5和25 μM)能显著抑制细胞迁移，肺转移小鼠模型显示，DKA(2.5、5和10 mg/kg)能强烈抑制MDA-MB-231乳腺癌细胞的肺转移。
{"title":"Ent-16β,17-dihydroxy-kauran-19-oic acid (DKA), a kaurane diterpenoid from Sigesbeckia pubescens(Makino) Makino, inhibits the migration of MDA-MB-231 breast cancer","authors":"Jianbin Wang , Rongxin Liu , Hao Chen , Anqi Chen , Li Chen","doi":"10.1080/14786419.2023.2287177","DOIUrl":"10.1080/14786419.2023.2287177","url":null,"abstract":"<div><div><em>Ent</em>-kaurane diterpenoids were studied as a biologically active ingredient group of <em>Sigesbeckia pubescens</em> (Makino) Makino. Here, five known <em>ent</em>-kaurane diterpenoids were isolated and identified, named <em>ent</em>-16<em>β</em>,17-dihydroxy-kauran-19-oic acid (<strong>1)</strong>, <em>ent</em>-16<em>β</em>,17-dihydroxy-kauran-19-oate (<strong>2)</strong>, <em>ent</em>-18-acetoxy-17-hydroxykauran-19-oic acid (<strong>3</strong>), <em>ent</em>-16<em>β</em>,17,18-trihydroxy-kauran-19 -oic acid (<strong>4</strong>), and <em>ent</em>-17-hydroxy-kauran-16<em>β</em>H-19-oic acid (<strong>5</strong>). Their inhibitory effects of these compounds on MDA-MB-231 breast cancer migration were firstly tested in a chemotaxis invasion assay. Among them, compound <strong>1</strong> (DKA) showed superior inhibitory activities with IC<sub>50</sub> value of 1.96 µM. Then, a wound healing assay and BALB/c nude mice were used for further studying the inhibitory activity of DKA on MDA-MB-231 breast cancer migration <em>in vitro</em> and <em>in vivo</em>, respectively. The wound healing assay showed that DKA (1, 5, and 25 μM) can significantly inhibit cell migration and the mouse model of lung metastasis showed that DKA (2.5, 5, and 10 mg/kg) could strongly suppress the lung metastasis of MDA-MB-231 breast cancer cells.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 689-694"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The GC and GC/MS analysis of the essential oil samples obtained separately from whole aerial parts and the roots of Laportea bulbifera resulted in the identification of a total of 40 compounds from the whole aerial parts and 45 compounds from the roots representing 89.7% and 82.9%, respectively, of the total essential oil composition. The essential oil from aerial parts is dominated by oxygenated sesquiterpenes (66.4%) with α-elemol (55.1%), germacrene D-4-ol (4.2%), linalool (3.5%) and phytol (3.4%) as the major constituents while the root essential oil is dominated by oxygenated monoterpenes (30.4%) with trans-myrtanol (16.3%), cis-myrtanol (11.6%), nopinone (7.8%), cadin-4-en-10-ol (4.7%), and α-elemol (3.4%) as major constituents. The essential oil from whole aerial parts showed bactericidal effect at 250 µL/mL concentration (MBC) against Pasteurella multocida and Dickeya dadantii while the root essential oil exhibited bactericidal effect at 125 µL/mL against Escherichia coli, Enterococcus faecalis, Xanthomonas phaseoli, and Dickeya dadantii.
采用GC和GC/MS分析方法，分别从黄连全部和根部提取精油样品，共鉴定出40个化合物。
{"title":"A comparative study on chemical composition and antibacterial activity of essential oils from the aerial parts and roots of Laportea bulbifera (Siebold & Zucc.) Wedd. growing in the Central Himalayan region","authors":"Manisha Palni , Leelawati Nitwal , Anand B. Melkani , Deepshikha Joshi , Rajendra Prasad","doi":"10.1080/14786419.2023.2289187","DOIUrl":"10.1080/14786419.2023.2289187","url":null,"abstract":"<div><div>The GC and GC/MS analysis of the essential oil samples obtained separately from whole aerial parts and the roots of <em>Laportea bulbifera</em> resulted in the identification of a total of 40 compounds from the whole aerial parts and 45 compounds from the roots representing 89.7% and 82.9%, respectively, of the total essential oil composition. The essential oil from aerial parts is dominated by oxygenated sesquiterpenes (66.4%) with <em>α-</em>elemol (55.1%), germacrene D-4-ol (4.2%), linalool (3.5%) and phytol (3.4%) as the major constituents while the root essential oil is dominated by oxygenated monoterpenes (30.4%) with <em>trans</em>-myrtanol (16.3%), <em>cis</em>-myrtanol (11.6%), nopinone (7.8%), cadin-4-en-10-ol (4.7%), and <em>α</em>-elemol (3.4%) as major constituents. The essential oil from whole aerial parts showed bactericidal effect at 250 µL/mL concentration (MBC) against <em>Pasteurella multocida</em> and <em>Dickeya dadantii</em> while the root essential oil exhibited bactericidal effect at 125 µL/mL against <em>Escherichia coli, Enterococcus faecalis</em>, <em>Xanthomonas phaseoli,</em> and <em>Dickeya dadantii</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 1010-1014"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138630627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intraocular pressure (IOP) positively correlates with both normal and high-tension glaucoma. To date, IOP targeting remains the validated pharmacological approach in counteracting glaucoma progression as well as in halting vision loss. Among the different adjuvant compounds, evidence highlighted the potential effectiveness of Palmitoylethanolamide (PEA), an endogenous fatty acid amide. Thus, a systematic review of the literature was conducted, thoroughly evaluating PEA treatment regimen in decreasing IOP in patients with eye disorders. We checked for articles across the scientific databases Pubmed (MEDLINE), Embase (OVID), and Web of Science from the inception to 30 August 2023, and a total of 828 articles were recovered. Six of these studies (199 patients) were included in the systematic review after the study selection process, and three studies for meta-analysia. Overall, PEA showed significant efficacy in reducing IOP in patients, this encourages its clinical use in glaucoma as well as across different forms of eye disorders.
眼压（IOP）与正常青光眼和高眼压性青光眼均呈正相关。迄今为止，针对眼压的药物疗法仍是对抗青光眼发展和阻止视力丧失的有效方法。在不同的辅助化合物中，有证据表明棕榈酰乙醇酰胺（PEA）--一种内源性脂肪酸酰胺--具有潜在的有效性。因此，我们对文献进行了系统性回顾，全面评估了 PEA 治疗方案在降低眼疾患者眼压方面的效果。我们在 Pubmed (MEDLINE)、Embase (OVID) 和 Web of Science 等科学数据库中检索了从开始到 2023 年 8 月 30 日的文章，共检索到 828 篇文章。经过研究筛选，其中六项研究（199 名患者）被纳入系统综述，三项研究被纳入荟萃分析。总体而言，PEA 在降低患者眼压方面具有显著疗效，这促进了其在青光眼以及各种眼部疾病中的临床应用。
{"title":"Evaluation of the nutraceutical Palmitoylethanolamide in reducing intraocular pressure (IOP) in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis","authors":"Lelio Crupi , Anna Paola Capra , Irene Paterniti , Marika Lanza , Fabrizio Calapai , Salvatore Cuzzocrea , Alessio Ardizzone , Emanuela Esposito","doi":"10.1080/14786419.2024.2306916","DOIUrl":"10.1080/14786419.2024.2306916","url":null,"abstract":"<div><div>Intraocular pressure (IOP) positively correlates with both normal and high-tension glaucoma. To date, IOP targeting remains the validated pharmacological approach in counteracting glaucoma progression as well as in halting vision loss. Among the different adjuvant compounds, evidence highlighted the potential effectiveness of Palmitoylethanolamide (PEA), an endogenous fatty acid amide. Thus, a systematic review of the literature was conducted, thoroughly evaluating PEA treatment regimen in decreasing IOP in patients with eye disorders. We checked for articles across the scientific databases Pubmed (MEDLINE), Embase (OVID), and Web of Science from the inception to 30 August 2023, and a total of 828 articles were recovered. Six of these studies (199 patients) were included in the systematic review after the study selection process, and three studies for meta-analysia. Overall, PEA showed significant efficacy in reducing IOP in patients, this encourages its clinical use in glaucoma as well as across different forms of eye disorders.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 797-816"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2024.2319655
Muhammad Khairil Rumaling , Siat Yee Fong , Pasupuleti Visweswara Rao , Johnny Gisil , Mohd Hijaz Mohd Sani , Wan Salman Wan Saudi
In tropical forests, Hoya, a plant with significant indigenous medicinal applications, has been underexplored in pharmacological studies. This systematic review meticulously investigates the diverse pharmacological effects exhibited by various Hoya species on human health. A comprehensive literature search, encompassing Scopus, ScienceDirect, and SpringerLink databases, employed specific keyword combinations (‘Hoya’ and ‘pharmacological properties’ OR ‘pharmacology property’). The included studies exclusively focused on Hoya’s impact on human health. The findings underscore Hoya’s potential as a medicinal plant, demonstrating promising attributes such as anticancer, antibacterial, antioxidant, anti-inflammatory, anti-diabetic, antinociceptive, and parasympatholytic effects. Despite these promising indications, the review underscores the necessity for further in vivo investigations to fully unlock Hoya’s therapeutic potential. A comprehensive understanding of its mechanisms of action, efficacy, and safety in living systems is imperative for realising its holistic therapeutic benefits.
{"title":"Pharmacological properties of Hoya (Apocynaceae): a systematic review","authors":"Muhammad Khairil Rumaling , Siat Yee Fong , Pasupuleti Visweswara Rao , Johnny Gisil , Mohd Hijaz Mohd Sani , Wan Salman Wan Saudi","doi":"10.1080/14786419.2024.2319655","DOIUrl":"10.1080/14786419.2024.2319655","url":null,"abstract":"<div><div>In tropical forests, <em>Hoya</em>, a plant with significant indigenous medicinal applications, has been underexplored in pharmacological studies. This systematic review meticulously investigates the diverse pharmacological effects exhibited by various <em>Hoya</em> species on human health. A comprehensive literature search, encompassing Scopus, ScienceDirect, and SpringerLink databases, employed specific keyword combinations (‘<em>Hoya’</em> and ‘pharmacological properties’ OR ‘pharmacology property’). The included studies exclusively focused on <em>Hoya’s</em> impact on human health. The findings underscore <em>Hoya’s</em> potential as a medicinal plant, demonstrating promising attributes such as anticancer, antibacterial, antioxidant, anti-inflammatory, anti-diabetic, antinociceptive, and parasympatholytic effects. Despite these promising indications, the review underscores the necessity for further <em>in vivo</em> investigations to fully unlock <em>Hoya’s</em> therapeutic potential. A comprehensive understanding of its mechanisms of action, efficacy, and safety in living systems is imperative for realising its holistic therapeutic benefits.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 905-921"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2282114
Hui Zhang , YanRu Wang , Yuhang Liang , Xu Zhao , Gang Chen
One previously undescribed prenylated flavonoid (1) and three known ones (2-4) were isolated from leaves of Epimedium brevicornu maxim. Their structures were determined through extensive spectroscopic analysis and comparison with the NMR data in the literature. Compound 1 showed a moderate cytotoxicity with an IC50 value of 18.7 μM, while known compounds 2 and 3 elicited weak cytotoxicities with IC50 values of 29.2 and 32.8 μM against Lewis Lung cancer cells (LLC cells), respectively.
{"title":"One new prenylated flavonoid with cytotoxic activity from Epimedium brevicornu maxim","authors":"Hui Zhang , YanRu Wang , Yuhang Liang , Xu Zhao , Gang Chen","doi":"10.1080/14786419.2023.2282114","DOIUrl":"10.1080/14786419.2023.2282114","url":null,"abstract":"<div><div>One previously undescribed prenylated flavonoid (<strong>1</strong>) and three known ones (<strong>2-4</strong>) were isolated from leaves of <em>Epimedium brevicornu</em> maxim. Their structures were determined through extensive spectroscopic analysis and comparison with the NMR data in the literature. Compound <strong>1</strong> showed a moderate cytotoxicity with an IC<sub>50</sub> value of 18.7 μM, while known compounds <strong>2</strong> and <strong>3</strong> elicited weak cytotoxicities with IC<sub>50</sub> values of 29.2 and 32.8 μM against Lewis Lung cancer cells (LLC cells), respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 981-984"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134647913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2286605
Aijiao Zhong , Peng Shen , Yue Sun , Jiaxin Feng , Junyi Zhu , Li Li , Zijing Wu , Hao Zang
Aegopodium alpestre Ledeb (A. alpestre) is a plant known for its fragrant smell and has been traditionally used to treat influenza. However, despite its widespread use, there is no research on its flowering aerial parts. This study aims to contribute to the understanding the flowering aerial parts by investigating its volatile oil. The essential oil was extracted through hydrodistillation and analysed using GC-MS. The analysis identified 54 compounds, which accounted for 95.16% of the oil composition. The major components are germacrene D (31.68%), β-caryophyllene (16.07%), and (E)-β-farnesene (7.99%). To evaluate the antioxidant activity of volatile oil, six antioxidant experiments were conducted. The results indicated that volatile oil exhibited significant 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt and hydroxyl radical scavenging abilities. Furthermore, the antibacterial activity of volatile oil was assessed against four common pathogenic bacteria. The findings demonstrated that volatile oil displayed potent antibacterial activity against Escherichia coli and Aerogenic bacterium.
{"title":"Chemical composition and biological evaluation of the essential oil of the flowering aerial parts of Aegopodium alpestre Ledeb","authors":"Aijiao Zhong , Peng Shen , Yue Sun , Jiaxin Feng , Junyi Zhu , Li Li , Zijing Wu , Hao Zang","doi":"10.1080/14786419.2023.2286605","DOIUrl":"10.1080/14786419.2023.2286605","url":null,"abstract":"<div><div><em>Aegopodium alpestre</em> Ledeb (<em>A. alpestre</em>) is a plant known for its fragrant smell and has been traditionally used to treat influenza. However, despite its widespread use, there is no research on its flowering aerial parts. This study aims to contribute to the understanding the flowering aerial parts by investigating its volatile oil. The essential oil was extracted through hydrodistillation and analysed using GC-MS. The analysis identified 54 compounds, which accounted for 95.16% of the oil composition. The major components are germacrene D (31.68%), <em>β</em>-caryophyllene (16.07%), and (<em>E</em>)-<em>β</em>-farnesene (7.99%). To evaluate the antioxidant activity of volatile oil, six antioxidant experiments were conducted. The results indicated that volatile oil exhibited significant 2,2’-azino-<em>bis</em>(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt and hydroxyl radical scavenging abilities. Furthermore, the antibacterial activity of volatile oil was assessed against four common pathogenic bacteria. The findings demonstrated that volatile oil displayed potent antibacterial activity against <em>Escherichia coli</em> and <em>Aerogenic bacterium</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 998-1003"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-16DOI: 10.1080/14786419.2023.2288232
Livia Reisen Perin , Luciana Alves Parreira , Estevão Carlos Silva Barcelos , Mario Ferreira Conceição Santos , Luciano Menini , Daniel de Oliveira Gomes , Francisco de Paula Careta
Cutaneous and visceral leishmaniasis are public health problems in Africa, Asia, Europe, and America. The treatment has a high cost and toxicity. Thus, this work aims to evaluate the leishmanicidal activity of alpha-bisabolol and its three synthetic derivatives, P1, P2, and P3, on the promastigotes and amastigotes Leishmania infantum and L. amazonensis forms. Alpha-bisabolol showed the lowest IC50 with 3.43 for L. amazonensis promastigotes, while P1 was the most toxic for L. infantum with an IC50 of 9.10. The derivative P3 was better for the amastigote form, with an IC50 of 3.39 for L. amazonensis. All the compounds effectively decreased the intracellular load of amastigote and its ability to turn promastigote again. Thus, alpha-bisabolol and its three synthetic derivatives were effective in their leishmanicidal activity. Therefore, it can be an option for developing new treatments against leishmaniasis.
{"title":"In vitro effect of alpha-bisabolol and its synthetic derivatives on macrophages, promastigotes, and amastigotes of Leishmania amazonensis and Leishmania infantum","authors":"Livia Reisen Perin , Luciana Alves Parreira , Estevão Carlos Silva Barcelos , Mario Ferreira Conceição Santos , Luciano Menini , Daniel de Oliveira Gomes , Francisco de Paula Careta","doi":"10.1080/14786419.2023.2288232","DOIUrl":"10.1080/14786419.2023.2288232","url":null,"abstract":"<div><div>Cutaneous and visceral leishmaniasis are public health problems in Africa, Asia, Europe, and America. The treatment has a high cost and toxicity. Thus, this work aims to evaluate the leishmanicidal activity of alpha-bisabolol and its three synthetic derivatives, P1, P2, and P3, on the promastigotes and amastigotes <em>Leishmania infantum</em> and <em>L. amazonensis</em> forms. Alpha-bisabolol showed the lowest IC<sub>50</sub> with 3.43 for <em>L. amazonensis</em> promastigotes, while P1 was the most toxic for <em>L. infantum</em> with an IC<sub>50</sub> of 9.10. The derivative P3 was better for the amastigote form, with an IC<sub>50</sub> of 3.39 for <em>L. amazonensis</em>. All the compounds effectively decreased the intracellular load of amastigote and its ability to turn promastigote again. Thus, alpha-bisabolol and its three synthetic derivatives were effective in their leishmanicidal activity. Therefore, it can be an option for developing new treatments against leishmaniasis.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 4","pages":"Pages 1004-1009"},"PeriodicalIF":1.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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