Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age.

IF 7.8 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY PLoS Biology Pub Date : 2023-08-17 eCollection Date: 2023-08-01 DOI:10.1371/journal.pbio.3002230
Elizabeth K Mallott, Alexandra R Sitarik, Leslie D Leve, Camille Cioffi, Carlos A Camargo, Kohei Hasegawa, Seth R Bordenstein
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Abstract

Human microbiome variation is linked to the incidence, prevalence, and mortality of many diseases and associates with race and ethnicity in the United States. However, the age at which microbiome variability emerges between these groups remains a central gap in knowledge. Here, we identify that gut microbiome variation associated with race and ethnicity arises after 3 months of age and persists through childhood. One-third of the bacterial taxa that vary across caregiver-identified racial categories in children are taxa reported to also vary between adults. Machine learning modeling of childhood microbiomes from 8 cohort studies (2,756 samples from 729 children) distinguishes racial and ethnic categories with 87% accuracy. Importantly, predictive genera are also among the top 30 most important taxa when childhood microbiomes are used to predict adult self-identified race and ethnicity. Our results highlight a critical developmental window at or shortly after 3 months of age when social and environmental factors drive race and ethnicity-associated microbiome variation and may contribute to adult health and health disparities.

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与种族和民族相关的人类微生物组变异最早在3个月大时出现。
在美国,人类微生物组变异与许多疾病的发病率、流行率和死亡率有关,并与种族和民族有关。然而,这些群体之间出现微生物组变异的年龄仍然是知识的核心差距。在这里,我们发现与种族和民族相关的肠道微生物组变异在3个月大后出现,并持续到儿童时期。三分之一的细菌分类群因照顾者确定的儿童种族类别而异,据报道,成年人之间的分类群也有所不同。来自8项队列研究的儿童微生物组的机器学习建模(来自729名儿童的2756个样本)以87%的准确率区分了种族和民族类别。重要的是,当儿童微生物群用于预测成年人自我识别的种族和民族时,预测属也是前30个最重要的分类群之一。我们的研究结果强调了一个关键的发育窗口,即在3个月大时或3个月后不久,社会和环境因素会导致种族和族裔相关的微生物组变异,并可能导致成人健康和健康差异。
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来源期刊
PLoS Biology
PLoS Biology 生物-生化与分子生物学
CiteScore
14.40
自引率
2.00%
发文量
359
审稿时长
3 months
期刊介绍: PLOS Biology is an open-access, peer-reviewed general biology journal published by PLOS, a nonprofit organization of scientists and physicians dedicated to making the world's scientific and medical literature freely accessible. The journal publishes new articles online weekly, with issues compiled and published monthly. ISSN Numbers: eISSN: 1545-7885 ISSN: 1544-9173
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