The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals.

IF 1.4 4区医学 Q4 CELL BIOLOGY Cell and Tissue Banking Pub Date : 2024-03-01 Epub Date: 2023-06-26 DOI:10.1007/s10561-023-10099-9

Mehdi Rasouli, Roya Fattahi, Ghader Nuoroozi, Zeinab Zarei-Behjani, Maliheh Yaghoobi, Zeinab Hajmohammadi, Simzar Hosseinzadeh

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Abstract

Oxygen pressure plays an integral role in regulating various aspects of cellular biology. Cell metabolism, proliferation, morphology, senescence, metastasis, and angiogenesis are some instances that are affected by different tensions of oxygen. Hyperoxia or high oxygen concentration, enforces the production of reactive oxygen species (ROS) that disturbs physiological homeostasis, and consequently, in the absence of antioxidants, cells and tissues are directed to an undesired fate. On the other side, hypoxia or low oxygen concentration, impacts cell metabolism and fate strongly through inducing changes in the expression level of specific genes. Thus, understanding the precise mechanism and the extent of the implication of oxygen tension and ROS in biological events is crucial to maintaining the desired cell and tissue function for application in regenerative medicine strategies. Herein, a comprehensive literature review has been performed to find out the impacts of oxygen tensions on the various behaviors of cells or tissues.

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氧张力在细胞命运和再生医学中的作用：缺氧/过氧和自由基的影响。

氧压在调节细胞生物学的各个方面发挥着不可或缺的作用。细胞的新陈代谢、增殖、形态、衰老、转移和血管生成都会受到不同氧压的影响。高氧或高浓度氧气会强制产生活性氧（ROS），从而扰乱生理平衡，因此，在缺乏抗氧化剂的情况下，细胞和组织会走向不可取的命运。另一方面，缺氧或低氧浓度通过诱导特定基因表达水平的变化，对细胞的新陈代谢和命运产生强烈影响。因此，了解氧张力和 ROS 在生物事件中的确切机制和影响程度，对于维持细胞和组织的理想功能以应用于再生医学策略至关重要。在此，我们进行了全面的文献综述，以了解氧张力对细胞或组织各种行为的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell and Tissue Banking CELL BIOLOGY-ENGINEERING, BIOMEDICAL

CiteScore

3.10

自引率

13.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell and Tissue Banking provides a forum for disseminating information to scientists and clinicians involved in the banking and transplantation of cells and tissues. Cell and Tissue Banking is an international, peer-reviewed journal that publishes original papers in the following areas: basic research concerning general aspects of tissue banking such as quality assurance and control of banked cells/tissues, effects of preservation and sterilisation methods on cells/tissues, biotechnology, etc.; clinical applications of banked cells/tissues; standards of practice in procurement, processing, storage and distribution of cells/tissues; ethical issues; medico-legal issues.