Using the Infant Sibling-Design to Explore Associations Between Autism and ADHD Traits in Probands and Temperament in the Younger Siblings.

IF 3.2 2区 心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL Journal of Autism and Developmental Disorders Pub Date : 2024-09-01 Epub Date: 2023-06-24 DOI:10.1007/s10803-023-06047-x
Linn Andersson Konke, Terje Falck-Ytter, Emily J H Jones, Amy Goodwin, Karin Brocki
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Abstract

The purpose of the current study was to use the infant sibling design to explore whether proband traits of autism and ADHD could provide information about their infant sibling's temperament. This could help us to gain information about the extent to which infant temperament traits are differentially associated with autism and ADHD traits. We used parent-ratings of autistic traits and ADHD traits (CRS-3) in older siblings diagnosed with autism (age range 4 to 19 years), and their infant siblings' temperament traits (IBQ) at 9 months of age in 216 sibling pairs from two sites (BASIS, UK, and EASE, Sweden) to examine associations across siblings. We found specific, but modest, associations across siblings after controlling for sex, age, developmental level and site. Proband autistic traits were specifically related to low levels of approach in the infant siblings, with infant developmental level explaining part of the variance in infant approach. Proband ADHD traits were specifically related to high levels of infant activity even after controlling for covariates. Our findings suggest that proband traits of autism and ADHD carry information for infant sibling's temperament, indicating that inherited liability may influence early emerging behaviours in infant siblings. The impact of sex, age, developmental level and site are discussed.

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利用婴儿兄弟姐妹设计探讨自闭症和多动症特质与年幼兄弟姐妹性情之间的关联。
本研究的目的是利用婴儿兄弟姐妹设计来探讨自闭症和多动症的原告特质是否能提供其婴儿兄弟姐妹的气质信息。这有助于我们了解婴儿的气质特征与自闭症和多动症特征之间的关联程度。我们利用父母对被诊断患有自闭症的年长兄弟姐妹(年龄范围为 4 至 19 岁)的自闭症特征和多动症特征(CRS-3)的评分,以及来自两个研究机构(英国 BASIS 研究机构和瑞典 EASE 研究机构)的 216 对 9 个月大的婴儿兄弟姐妹的气质特征(IBQ),来研究不同兄弟姐妹之间的关联。在对性别、年龄、发育水平和研究地点进行控制后,我们发现不同兄弟姐妹之间存在特定但适度的关联。Proband 自闭症特质与婴儿兄弟姐妹的低亲近水平特别相关,而婴儿的发育水平可以解释婴儿亲近水平的部分差异。即使在控制了协变量之后,原带多动症特质仍与婴儿的高活动水平有特殊关系。我们的研究结果表明,自闭症和多动症的原发特质会对婴儿兄弟姐妹的性情产生影响,这表明遗传因素可能会影响婴儿兄弟姐妹的早期行为。我们还讨论了性别、年龄、发育水平和地点的影响。
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来源期刊
CiteScore
8.00
自引率
10.30%
发文量
433
期刊介绍: The Journal of Autism and Developmental Disorders seeks to advance theoretical and applied research as well as examine and evaluate clinical diagnoses and treatments for autism and related disabilities. JADD encourages research submissions on the causes of ASDs and related disorders, including genetic, immunological, and environmental factors; diagnosis and assessment tools (e.g., for early detection as well as behavioral and communications characteristics); and prevention and treatment options. Sample topics include: Social responsiveness in young children with autism Advances in diagnosing and reporting autism Omega-3 fatty acids to treat autism symptoms Parental and child adherence to behavioral and medical treatments for autism Increasing independent task completion by students with autism spectrum disorder Does laughter differ in children with autism? Predicting ASD diagnosis and social impairment in younger siblings of children with autism The effects of psychotropic and nonpsychotropic medication with adolescents and adults with ASD Increasing independence for individuals with ASDs Group interventions to promote social skills in school-aged children with ASDs Standard diagnostic measures for ASDs Substance abuse in adults with autism Differentiating between ADHD and autism symptoms Social competence and social skills training and interventions for children with ASDs Therapeutic horseback riding and social functioning in children with autism Authors and readers of the Journal of Autism and Developmental Disorders include sch olars, researchers, professionals, policy makers, and graduate students from a broad range of cross-disciplines, including developmental, clinical child, and school psychology; pediatrics; psychiatry; education; social work and counseling; speech, communication, and physical therapy; medicine and neuroscience; and public health.
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