The Impact of Air Pollution on Atopic Dermatitis.

IF 5.4 2区医学 Q1 ALLERGY Current Allergy and Asthma Reports Pub Date : 2023-08-01 DOI:10.1007/s11882-023-01095-w

Austin Lai, Kelly Owens, Surya Patel, Matilda Nicholas

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Abstract

Purpose of review: Atopic dermatitis (AD) remains a dermatological disease that imposes a significant burden on society. Air pollution has previously been linked to both the onset and severity of atopic dermatitis. As air pollution remains a critical environmental factor impacting human health, this review seeks to provide an overview of the relationship between different air pollutants and AD.

Recent findings: AD can develop from multiple causes that can be broadly grouped into epidermal barrier dysfunction and immune dysregulation. Air pollution imposes significant health risks and includes a wide variety of pollutant types. AD has been linked to outdoor air pollutants such as particulate matter (PM), volatile organic compounds (VOC), gaseous compounds, and heavy metals. Exposure to indoor pollutants such as tobacco smoke and fungal molds has also been associated with an increased incidence of AD. While different pollutants impact distinct molecular pathways in the cell, they mostly converge on ROS product, DNA damage, and dysregulated T-cell activity and cytokine production. The presented review suggests a strengthening tie between air pollution and AD. It points to opportunities for further studies to clarify, as well as potential therapeutic opportunities that leverage the mechanistic relationships between air pollution and AD.

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空气污染对特应性皮炎的影响。

综述目的:特应性皮炎(AD)仍然是一种皮肤病，对社会造成了重大负担。此前，空气污染与特应性皮炎的发病和严重程度有关。由于空气污染仍然是影响人类健康的关键环境因素，本综述旨在概述不同空气污染物与AD之间的关系。最近的研究发现:AD可由多种原因引起，可大致分为表皮屏障功能障碍和免疫失调。空气污染造成重大的健康风险，包括各种各样的污染物类型。AD与室外空气污染物有关，如颗粒物(PM)、挥发性有机化合物(VOC)、气态化合物和重金属。暴露于室内污染物(如烟草烟雾和真菌霉菌)也与阿尔茨海默病的发病率增加有关。虽然不同的污染物影响细胞中不同的分子途径，但它们大多集中在ROS产物、DNA损伤、t细胞活性和细胞因子产生失调上。这一综述表明，空气污染与AD之间的联系日益密切。它指出了进一步研究澄清的机会，以及利用空气污染和AD之间的机制关系的潜在治疗机会。

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来源期刊

Current Allergy and Asthma Reports 医学-过敏

CiteScore

11.20

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma. We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.

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