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Basophil Activation Test for the Improved Diagnosis of Peanut and Tree Nut Allergy.
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-03-20 DOI: 10.1007/s11882-025-01200-1
Orlee Marini-Rapoport, Moumita Bhowmik, Sarita U Patil

Purpose of review: As an ex-vivo test of allergic effector cell activation, basophil activation testing (BAT) to allergen enables quantification of the in-vivo IgE-mediated allergic response. BAT thus holds promise in the diagnosis and monitoring of peanut and tree nut allergies. Recent systematic analyses and expert recommendations support a role for BAT in the diagnosis of peanut and tree nut allergy.

Recent findings: Diagnostic cut-offs for BAT in peanut and tree nut allergy have been identified. Consistently, BAT can discriminate with high sensitivity and specificity between allergy and tolerance when measured against oral food challenges. Furthermore, the utilization of BAT has can increase the sensitivity and specificity of peanut allergy and tree nut allergy diagnosis, both alone and in conjunction with specific IgE testing and skin prick testing. BAT is a promising tool in the diagnosis of peanut and tree nut allergy.

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引用次数: 0
T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker?
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-03-17 DOI: 10.1007/s11882-025-01199-5
Qingxiu Xu, Le Li, Rongfei Zhu

Purpose of review: This review explores the emerging role of T cell exhaustion in allergic diseases and allergen immunotherapy (AIT). It aims to synthesize current knowledge on the mechanisms of T cell exhaustion, evaluate its potential involvement in allergic inflammation, and assess its implications as a novel biomarker for predicting and monitoring AIT efficacy.

Recent findings: Recent studies highlight that T cell exhaustion, characterized by co-expression of inhibitory receptors (e.g., PD-1, CTLA-4, TIM-3), diminished cytokine production, and altered transcriptional profiles, may suppress type 2 inflammation in allergic diseases. In allergic asthma, exhausted CD4 + T cells exhibit upregulated inhibitory receptors, correlating with reduced IgE levels and airway hyperreactivity. During AIT, prolonged high-dose allergen exposure drives allergen-specific Th2 and T follicular helper (Tfh) cell exhaustion, potentially contributing to immune tolerance. Notably, clinical improvements in AIT correlate with depletion of allergen-specific Th2 cells and persistent expression of exhaustion markers (e.g., PD-1, CTLA-4) during maintenance phases. Blockade of inhibitory receptors (e.g., PD-1) enhances T cell activation, underscoring their dual regulatory role in allergy. T cell exhaustion represents a double-edged sword in allergy: it may dampen pathological inflammation in allergic diseases while serving as a mechanism for AIT-induced tolerance. The co-expression of inhibitory receptors on allergen-specific T cells emerges as a promising biomarker for AIT efficacy. Future research should clarify the transcriptional and metabolic drivers of exhaustion in allergy, validate its role across diverse allergic conditions, and optimize strategies to harness T cell exhaustion for durable immune tolerance. These insights could revolutionize therapeutic approaches and biomarker development in allergy management.

{"title":"T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker?","authors":"Qingxiu Xu, Le Li, Rongfei Zhu","doi":"10.1007/s11882-025-01199-5","DOIUrl":"https://doi.org/10.1007/s11882-025-01199-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review explores the emerging role of T cell exhaustion in allergic diseases and allergen immunotherapy (AIT). It aims to synthesize current knowledge on the mechanisms of T cell exhaustion, evaluate its potential involvement in allergic inflammation, and assess its implications as a novel biomarker for predicting and monitoring AIT efficacy.</p><p><strong>Recent findings: </strong>Recent studies highlight that T cell exhaustion, characterized by co-expression of inhibitory receptors (e.g., PD-1, CTLA-4, TIM-3), diminished cytokine production, and altered transcriptional profiles, may suppress type 2 inflammation in allergic diseases. In allergic asthma, exhausted CD4 + T cells exhibit upregulated inhibitory receptors, correlating with reduced IgE levels and airway hyperreactivity. During AIT, prolonged high-dose allergen exposure drives allergen-specific Th2 and T follicular helper (Tfh) cell exhaustion, potentially contributing to immune tolerance. Notably, clinical improvements in AIT correlate with depletion of allergen-specific Th2 cells and persistent expression of exhaustion markers (e.g., PD-1, CTLA-4) during maintenance phases. Blockade of inhibitory receptors (e.g., PD-1) enhances T cell activation, underscoring their dual regulatory role in allergy. T cell exhaustion represents a double-edged sword in allergy: it may dampen pathological inflammation in allergic diseases while serving as a mechanism for AIT-induced tolerance. The co-expression of inhibitory receptors on allergen-specific T cells emerges as a promising biomarker for AIT efficacy. Future research should clarify the transcriptional and metabolic drivers of exhaustion in allergy, validate its role across diverse allergic conditions, and optimize strategies to harness T cell exhaustion for durable immune tolerance. These insights could revolutionize therapeutic approaches and biomarker development in allergy management.</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"18"},"PeriodicalIF":5.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases.
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-03-14 DOI: 10.1007/s11882-025-01196-8
Henry Sutanto, Galih Januar Adytia, Deasy Fetarayani

Purpose of review: It seeks to answer key questions about the molecular and cellular mechanisms underlying Hyper IgE Syndrome (HIES), the genetic mutations responsible, and their contributions to both immunodeficiency and allergic manifestations. Additionally, it aims to explore diagnostic strategies and therapeutic approaches that address these overlapping domains, thereby improving disease management.

Recent findings: Recent research has identified several pivotal genetic mutations, including those in STAT3, DOCK8, and PGM3, which play critical roles in disrupting immune pathways such as Th17 differentiation and IgE regulation. These molecular defects have been linked to the hallmark features of HIES, including recurrent infections and elevated serum IgE levels, as well as its overlap with atopic conditions like eczema, asthma, and food allergies. Advances in diagnostic tools, such as biomarker identification and genetic testing, have improved the differentiation of HIES from more common atopic disorders. Therapeutic advancements, including the use of targeted biologics and interventions addressing both immunodeficiency and allergic symptoms, have shown promise in enhancing patient outcomes. This review highlights the role of specific genetic mutations in shaping the clinical and immunological phenotype of HIES. Key takeaways include the necessity of integrating molecular insights with clinical observations for accurate diagnosis and the potential of emerging targeted therapies to address both immunological and allergic aspects of the syndrome.

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引用次数: 0
Herbal Medicine in Acute and Chronic Sinusitis; Still a Cinderella?
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-03-11 DOI: 10.1007/s11882-025-01195-9
Alexios Vardouniotis, Maria Doulaptsi, Georgia Liva, Ioannis Vlastos, Alexander Karatzanis, Emmanuel Prokopakis

Purpose of review: To set the context of current knowledge regarding the role of herbal medicine in acute and chronic rhinosinusitis treatment.

Recent findings: It is estimated that adults experience 1-3 episodes of viral rhinosinusitis per year and this number increases up to 8-10 episodes in preschool children. The symptoms of acute rhinosinusitis tend to significantly overlap with symptoms of other upper respiratory infections, making the diagnosis quite difficult. The division of rhinosinusitis into bacterial or non-bacterial is clinically important in order to determine appropriate treatment and the administration of antibiotic treatment. Treatment of acute rhinosinusitis is symptomatic and includes nasal rinsing, decongestants, corticosteroids, and combinations of the above. Herbal medicine has been traditionally underestimated in Western world. Nowadays, however, treatment of diseases with the use of medicinal plant treatments is gaining more and more followers. In this context, certain herbal extracts have been tested for viral, post- viral and chronic rhinosinusitis. Phytoneering is an innovative pharmaceutical technique in research and production of herbal medicines. Herbal extracts produced with phytoneering vary in quality and active substances. In terms of quality, safety and efficacy, herbal medicines are at least on par with synthetically produced medicines, having significantly less unwanted side effects. Certain herbal extracts have been tested, and in cases of acute rhinosinusitis are effective. In chronic sinusitis those extracts show promising results and might prove a good alternative without side effects.

{"title":"Herbal Medicine in Acute and Chronic Sinusitis; Still a Cinderella?","authors":"Alexios Vardouniotis, Maria Doulaptsi, Georgia Liva, Ioannis Vlastos, Alexander Karatzanis, Emmanuel Prokopakis","doi":"10.1007/s11882-025-01195-9","DOIUrl":"10.1007/s11882-025-01195-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>To set the context of current knowledge regarding the role of herbal medicine in acute and chronic rhinosinusitis treatment.</p><p><strong>Recent findings: </strong>It is estimated that adults experience 1-3 episodes of viral rhinosinusitis per year and this number increases up to 8-10 episodes in preschool children. The symptoms of acute rhinosinusitis tend to significantly overlap with symptoms of other upper respiratory infections, making the diagnosis quite difficult. The division of rhinosinusitis into bacterial or non-bacterial is clinically important in order to determine appropriate treatment and the administration of antibiotic treatment. Treatment of acute rhinosinusitis is symptomatic and includes nasal rinsing, decongestants, corticosteroids, and combinations of the above. Herbal medicine has been traditionally underestimated in Western world. Nowadays, however, treatment of diseases with the use of medicinal plant treatments is gaining more and more followers. In this context, certain herbal extracts have been tested for viral, post- viral and chronic rhinosinusitis. Phytoneering is an innovative pharmaceutical technique in research and production of herbal medicines. Herbal extracts produced with phytoneering vary in quality and active substances. In terms of quality, safety and efficacy, herbal medicines are at least on par with synthetically produced medicines, having significantly less unwanted side effects. Certain herbal extracts have been tested, and in cases of acute rhinosinusitis are effective. In chronic sinusitis those extracts show promising results and might prove a good alternative without side effects.</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"15"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of the Environment and Occupational Exposures in Chronic Rhinosinusitis.
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-03-11 DOI: 10.1007/s11882-025-01197-7
W Jared Martin, Yasine Mirmozaffari, Lauren M Cook, Ezer H Benaim, Aurelia S Monk, Michael Armstrong, Jackson Vuncannon, Cristine Klatt-Cromwell, Charles S Ebert, Brian D Thorp, Brent A Senior, Tom Raz Yarkoni, Adam J Kimple

Purpose of review: The purpose of the review is to summarize the current literature and evaluate how different environmental exposures may contribute to the development and course of chronic rhinosinusitis (CRS). The review aims to explore the relationship between host factors and environmental exposures in the pathogenesis of CRS.

Recent findings: Recent studies have helped establish the role of air pollutants, tobacco smoke, occupational exposures, and microplastics in the pathogenesis of CRS. These exposures have been shown to cause epithelial dysfunction and promote inflammation through different mechanisms and to different degrees. The pathogenesis of CRS is complex and multifactorial, with environmental exposures playing a key role in its onset and exacerbation. Research indicates that pollutants can damage the sinonasal epithelial barrier and disrupt the microbiome, leading to increased inflammation. A deeper understanding of the mechanisms behind this inflammatory process and its link to environmental exposures could enhance strategies for preventing and treating CRS.

{"title":"The Role of the Environment and Occupational Exposures in Chronic Rhinosinusitis.","authors":"W Jared Martin, Yasine Mirmozaffari, Lauren M Cook, Ezer H Benaim, Aurelia S Monk, Michael Armstrong, Jackson Vuncannon, Cristine Klatt-Cromwell, Charles S Ebert, Brian D Thorp, Brent A Senior, Tom Raz Yarkoni, Adam J Kimple","doi":"10.1007/s11882-025-01197-7","DOIUrl":"https://doi.org/10.1007/s11882-025-01197-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of the review is to summarize the current literature and evaluate how different environmental exposures may contribute to the development and course of chronic rhinosinusitis (CRS). The review aims to explore the relationship between host factors and environmental exposures in the pathogenesis of CRS.</p><p><strong>Recent findings: </strong>Recent studies have helped establish the role of air pollutants, tobacco smoke, occupational exposures, and microplastics in the pathogenesis of CRS. These exposures have been shown to cause epithelial dysfunction and promote inflammation through different mechanisms and to different degrees. The pathogenesis of CRS is complex and multifactorial, with environmental exposures playing a key role in its onset and exacerbation. Research indicates that pollutants can damage the sinonasal epithelial barrier and disrupt the microbiome, leading to increased inflammation. A deeper understanding of the mechanisms behind this inflammatory process and its link to environmental exposures could enhance strategies for preventing and treating CRS.</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"16"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burden of Respiratory Syncytial Virus Disease in Adults with Asthma and Chronic Obstructive Pulmonary Disease: A Systematic Literature Review.
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-02-25 DOI: 10.1007/s11882-025-01194-w
Yolanda Penders, Guy Brusselle, Ann R Falsey, Gernot Rohde, Estefania Betancur, Maria Elena Guardado, Juan Luis Ramirez Agudelo, Pouya Saeedi, Lauriane Harrington, Jean-Philippe Michaud

Purpose of review: Accumulating data indicate that asthma and chronic obstructive pulmonary disease (COPD) increase the risk of severe respiratory syncytial virus (RSV) infection. This systematic literature review assessed the burden of RSV disease among adults ≥ 18 years with asthma or COPD.

Recent findings: Data on the prevalence of asthma or COPD among RSV-infected adults, RSV-related hospitalizations, complications, and mortality were collected from studies published between January 1, 2000 and November 28, 2023 in PubMed, Embase, and grey literature. All extracted data were analyzed descriptively. Pooled estimates of asthma or COPD prevalence among RSV-infected adults were calculated from generalized linear mixed effects model meta-analyses. Forty studies were included. The prevalence of asthma and COPD among RSV-infected adults was high, especially in inpatient settings with pooled estimates (95% confidence interval) of 19.3% (15.0-24.6) for asthma and 30.8% (26.1-36.0) for COPD. Adults with asthma or COPD were more likely to be hospitalized following RSV infection than those without these conditions. The incidence rate ratios of hospitalization were 2.0-3.6 (crude) and 6.7-8.2 (adjusted) for asthma and 3.2-13.4 (crude) and 9.6-9.7 (adjusted) for COPD. The most frequently reported RSV-related complications were exacerbation of asthma (up to 64.9%) and COPD (up to ≥ 83.0%). In-hospital case fatality rates were 2.6-4.3% (asthma) and 2.8-17.8% (COPD). These comprehensive data showing a high RSV disease burden in adults with asthma or COPD can be used to inform policy decisions around RSV vaccines and improve preventive care in this high-risk population.

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引用次数: 0
Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis.
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-02-05 DOI: 10.1007/s11882-025-01192-y
Miguel Rodriguez-Iglesias, Christian Calvo-Henríquez, Daniel Martin-Jimenez, Ainhoa García-Lliberós, Juan Maza-Solano, Ramon Moreno-Luna, Adriana Izquierdo-Domínguez, Gabriel Martínez-Capoccioni, Isam Alobid

Purpose of review: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating inflammatory condition that significantly impacts quality of life. Despite treatment advances, recurrence is common, prompting the exploration of novel therapies such as monoclonal antibodies targeting the type 2 immune response, notably dupilumab. This research aims to evaluate the real-world evidence (RWE) of dupilumab in treating severe CRSwNP, comparing sinonasal outcomes to those observed in randomized clinical trials.

Recent findings: Significant improvements were noted, with the average SNOT-22 score reduction being 37.2 points post-dupilumab treatment. The nasal polyp size (NPS) showed an average decrease of 3.6 points. The analysis highlighted the practical effectiveness of dupilumab, emphasizing its benefit over conventional therapies in reducing NPS and improving nasal symptoms. The findings advocate for the integration of dupilumab into standard treatment protocols for severe CRSwNP, providing a robust alternative that could potentially reduce the high recurrence rates associated with current management strategies. This study underscores the utility of RWE in assessing the effectiveness of new medical treatments, suggesting that dupilumab offers substantial real-world benefits for patients suffering from this challenging condition.

{"title":"Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis.","authors":"Miguel Rodriguez-Iglesias, Christian Calvo-Henríquez, Daniel Martin-Jimenez, Ainhoa García-Lliberós, Juan Maza-Solano, Ramon Moreno-Luna, Adriana Izquierdo-Domínguez, Gabriel Martínez-Capoccioni, Isam Alobid","doi":"10.1007/s11882-025-01192-y","DOIUrl":"10.1007/s11882-025-01192-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating inflammatory condition that significantly impacts quality of life. Despite treatment advances, recurrence is common, prompting the exploration of novel therapies such as monoclonal antibodies targeting the type 2 immune response, notably dupilumab. This research aims to evaluate the real-world evidence (RWE) of dupilumab in treating severe CRSwNP, comparing sinonasal outcomes to those observed in randomized clinical trials.</p><p><strong>Recent findings: </strong>Significant improvements were noted, with the average SNOT-22 score reduction being 37.2 points post-dupilumab treatment. The nasal polyp size (NPS) showed an average decrease of 3.6 points. The analysis highlighted the practical effectiveness of dupilumab, emphasizing its benefit over conventional therapies in reducing NPS and improving nasal symptoms. The findings advocate for the integration of dupilumab into standard treatment protocols for severe CRSwNP, providing a robust alternative that could potentially reduce the high recurrence rates associated with current management strategies. This study underscores the utility of RWE in assessing the effectiveness of new medical treatments, suggesting that dupilumab offers substantial real-world benefits for patients suffering from this challenging condition.</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"13"},"PeriodicalIF":5.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypersensitivity Reactions to Anticonvulsants.
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-01-29 DOI: 10.1007/s11882-024-01188-0
Unaiza Faizan, Allison Ramsey

Background: Antiepileptics are the mainstay of treatment for seizure management. Immediate and delayed hypersensitivity reactions associated with antiepileptics are common. It is important to differentiate between these reactions as management and prognosis varies.

Objective: This review article aims to describe the types of hypersensitivity reactions reported with antiepileptics with emphasis on delayed hypersensitivity reactions, as these can be life-threatening.

Methods: Online databases including PubMed and Cochrane were searched, from the inception of the literature to 5/10/24. Studies focusing on hypersensitivity reactions to antiepileptics were reviewed. Case reports, case series, observational studies, and clinical trials were included. Abstracts and studies published in languages other than English were not included.

Results: Immediate reactions can occur with antiepileptics however the incidence is lower than that of delayed hypersensitivity reactions. Delayed hypersensitivity reactions include benign rash as well as severe cutaneous adverse reactions. Acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms, Steven Johnson syndrome, and toxic epidermal necrolysis are discussed in detail in this review. We focused on pathogenesis, genetic predisposition, clinical presentation, treatment, and prognosis.

Conclusion: Severe cutaneous adverse reactions can be lethal. It is important to make the correct diagnosis and treat patients accordingly. More studies comparing therapeutic options head-to-head are needed.

{"title":"Hypersensitivity Reactions to Anticonvulsants.","authors":"Unaiza Faizan, Allison Ramsey","doi":"10.1007/s11882-024-01188-0","DOIUrl":"https://doi.org/10.1007/s11882-024-01188-0","url":null,"abstract":"<p><strong>Background: </strong>Antiepileptics are the mainstay of treatment for seizure management. Immediate and delayed hypersensitivity reactions associated with antiepileptics are common. It is important to differentiate between these reactions as management and prognosis varies.</p><p><strong>Objective: </strong>This review article aims to describe the types of hypersensitivity reactions reported with antiepileptics with emphasis on delayed hypersensitivity reactions, as these can be life-threatening.</p><p><strong>Methods: </strong>Online databases including PubMed and Cochrane were searched, from the inception of the literature to 5/10/24. Studies focusing on hypersensitivity reactions to antiepileptics were reviewed. Case reports, case series, observational studies, and clinical trials were included. Abstracts and studies published in languages other than English were not included.</p><p><strong>Results: </strong>Immediate reactions can occur with antiepileptics however the incidence is lower than that of delayed hypersensitivity reactions. Delayed hypersensitivity reactions include benign rash as well as severe cutaneous adverse reactions. Acute generalized exanthematous pustulosis, drug rash with eosinophilia and systemic symptoms, Steven Johnson syndrome, and toxic epidermal necrolysis are discussed in detail in this review. We focused on pathogenesis, genetic predisposition, clinical presentation, treatment, and prognosis.</p><p><strong>Conclusion: </strong>Severe cutaneous adverse reactions can be lethal. It is important to make the correct diagnosis and treat patients accordingly. More studies comparing therapeutic options head-to-head are needed.</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"12"},"PeriodicalIF":5.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of the Indoor Environment on Childhood Asthma.
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-01-27 DOI: 10.1007/s11882-025-01193-x
Ellen R Conroy, Wanda Phipatanakul, Tina M Banzon

Purpose of review: This manuscript reviews the impact of important indoor environmental exposures on pediatric asthma, with a focus on recent literature in the field.

Recent findings: Studies continue to support an association between numerous indoor aeroallergens and air pollutants found in homes and schools and increased asthma morbidity overall. Several recent home and school intervention studies have shown promise, though results have been overall mixed. Indoor environmental exposures contribute to the development of asthma and impact asthma morbidity. Further research is needed to improve our understanding of how to optimize mitigation of these indoor exposures to significantly affect asthma outcomes.

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引用次数: 0
Parosmia: Pathophysiology and Management. 失语症:病理生理学和治疗。
IF 5.4 2区 医学 Q1 ALLERGY Pub Date : 2025-01-16 DOI: 10.1007/s11882-024-01189-z
Xinni Xu, Jerry Hadi Juratli, Basile Nicolas Landis, Thomas Hummel

Purpose of review: Parosmia is a qualitative olfactory disorder in which there is a mismatch between the memory of an odor and the actual experience triggered by an odor. There has been a surge in parosmia-related publications since the COVID-19 pandemic. This review summarizes the latest clinical findings, theories on pathophysiology and potential treatment options.

Recent advances: Potential models of parosmia include peripheral or central hypotheses, which refer to aberrancies in olfactory neuron regeneration or information processing in central olfactory centers respectively. This leads to an incomplete or disorganized pattern of olfactory information relay. Studies using gas chromatography and functional magnetic resonance imaging have identified molecular triggers and intracranial functional connectivity patterns in parosmia respectively. Parosmia tends to occur in a delayed fashion after virus-induced anosmia. It may run a protracted course, but typically improves over time. Currently there are no generally approved, objective ways to ascertain the presence and measure the extent of parosmia. Evidence-based treatment for parosmia remains elusive. In some people, this can lead to health and quality of life issues.

回顾目的:嗅觉缺失症是一种定性嗅觉障碍,其中气味的记忆与气味引发的实际体验之间存在不匹配。自2019冠状病毒病大流行以来,与寄生虫相关的出版物激增。本文综述了最新的临床发现、病理生理学理论和潜在的治疗方案。最新进展:嗅觉缺失的潜在模型包括外周假说和中枢假说,它们分别是指嗅觉神经元再生或中央嗅觉中心信息处理的异常。这导致嗅觉信息传递模式不完整或混乱。通过气相色谱和功能磁共振成像的研究分别确定了腮腺畸形的分子诱因和颅内功能连接模式。在病毒引起的嗅觉缺失之后,嗅觉缺失往往以延迟的方式发生。它可能会持续很长时间,但通常会随着时间的推移而改善。目前还没有被普遍认可的客观的方法来确定是否存在并测量嗅觉缺失的程度。以证据为基础的腮帮子畸形治疗仍然难以捉摸。对一些人来说,这可能会导致健康和生活质量问题。
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引用次数: 0
期刊
Current Allergy and Asthma Reports
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