Alterations of gut microbiome and metabolism induced by inulin associated with weight loss in obese female mice.

IF 3.5 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY International Journal of Food Sciences and Nutrition Pub Date : 2023-09-01 DOI:10.1080/09637486.2023.2235901

Zeang Wu, Mei Zhang, Yuhong Deng, Guangyuan Zhou, Meng Yang, Haixia Wang

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Abstract

Our previous work revealed the microbiota-dependent beneficial effects of inulin in obese male mice, but the effects in obese female mice were not determined. High-fat diet (HFD)-induced obese female mice were switched to normal diets and gavaged with normal saline or inulin for 10 weeks. Inulin supplementation significantly accelerated weight loss and reversed HFD-induced gut microbiota dysbiosis in obese female mice, and also reduced the ratio of Firmicutes/Bacteroidetes and enriched the abundance of norank_f_Muribaculaceae and Alistipes. In addition, 52 key serum metabolites were distinctly altered after inulin supplementation. Among them, andrographolide and monoacylglycerols (18:4) increased more than 9-fold and 14-fold, respectively, while phosphatidylcholine (PC) (18:1e/2:0), PC (20:1/20:2) and PC (19:1/19:1) decreased. In conclusion, gut microbiota and metabolites were closely associated with the beneficial effects of inulin in accelerating weight loss in obese female mice.

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菊粉诱导的肠道微生物组和代谢的改变与肥胖雌性小鼠体重减轻有关。

我们之前的工作揭示了菊粉对肥胖雄性小鼠的微生物依赖的有益作用，但对肥胖雌性小鼠的作用尚未确定。将高脂饮食诱导的肥胖雌性小鼠转换为正常饮食，并用生理盐水或菊粉灌胃10周。在肥胖雌性小鼠中，添加菊粉显著加速了体重减轻，逆转了hfd诱导的肠道微生物群失调，还降低了厚壁菌门/拟杆菌门的比例，增加了norank_f_Muribaculaceae和Alistipes的丰度。此外，添加菊粉后，52种关键的血清代谢物明显改变。其中，穿心莲内酯和单酰基甘油(18:4)含量分别增加了9倍和14倍以上，磷脂酰胆碱(PC) (18:11 e/2:0)、PC(20:1/20:2)和PC(19:1/19:1)含量减少。综上所述，肠道菌群和代谢物与菊粉加速肥胖雌性小鼠减肥的有益作用密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Food Sciences and Nutrition 工程技术-食品科技

CiteScore

7.50

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.