Comparison of Ibuprofen with Ketorolac on the Control of Renal Colic Pain: A Meta-Analysis of Randomized Controlled Studies.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urology Journal Pub Date : 2023-12-26 DOI:10.22037/uj.v20i.7572

Fuxian Cai, Yougang Liao, Shichun Jiang, Yuan Cao, Yaodong Wang

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Abstract

Purpose: The comparison of ibuprofen with ketorolac remains controversial for the pain control of renal colic. We therefore conduct this meta-analysis to compare the analgesic efficacy of ibuprofen with ketorolac for renal colic.

Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through December 2022 for randomized controlled trials (RCTs) assessing the analgesic efficacy of ibuprofen in comparison with ketorolac for renal colic. This meta-analysis was performed using the random-effect or fixed-effect model based on the heterogeneity.

Results: Four RCTs were included in the meta-analysis. In patients with renal colic pain, intravenous ibuprofen and ketorolac produced comparable pain scores at 15 min (MD = -0.46; 95% CI = -1.24 to 0.31; P = 0.24), 30 min (MD = -0.81; 95% CI = -1.75 to 0.31; P = 0.09), 60 min (MD=-0.63; 95% CI = -1.40 to 0.13; P = 0.10) and 120 min (MD = -0.74; 95% CI = -2.18 to 0.70; P = 0.31), as well as adverse events (OR = 0.95; 95% CI = 0.61 to 1.49; P = 0.83).

Conclusion: Ibuprofen can obtain comparable analgesic efficacy to ketorolac for renal colic pain.

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布洛芬与酮咯酸在控制肾绞痛方面的比较：随机对照研究的 Meta 分析。

目的：在控制肾绞痛疼痛方面，布洛芬与酮咯酸的比较仍存在争议。因此，我们进行了这项荟萃分析，比较布洛芬与酮咯酸治疗肾绞痛的镇痛效果：截至 2022 年 12 月，我们在 PubMed、EMbase、Web of science、EBSCO 和 Cochrane 图书馆数据库中检索了评估布洛芬与酮咯酸治疗肾绞痛镇痛效果的随机对照试验 (RCT)。本荟萃分析根据异质性采用随机效应或固定效应模型：荟萃分析纳入了四项研究。在肾绞痛患者中，静脉注射布洛芬和酮洛酸在 15 分钟（MD = -0.46; 95% CI = -1.24 to 0.31; P = 0.24）、30 分钟（MD = -0.81; 95% CI = -1.75 to 0.31；P=0.09）、60 min（MD=-0.63；95% CI=-1.40~0.13；P=0.10）和120 min（MD=-0.74；95% CI=-2.18~0.70；P=0.31），以及不良事件（OR=0.95；95% CI=0.61~1.49；P=0.83）.结论：结论：布洛芬对肾绞痛的镇痛效果与酮咯酸相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.