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Predictive Urodynamic Parameters for The Treatment Efficacy of Onabotulinum Toxin A in Neurogenic Lower Urinary Tract Dysfunction.
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v22i.8289
Muharrem Baturu, Ömer Bayrak, Yusuf Yaşar, Özlem Başgut, İlker Seçkiner

Purpose: To evaluate urodynamic parameters that may serve as predictors of treatment efficacy with Onabotulinumtoxin-A (onaBoNT-A) in patients with neurogenic lower urinary tract dysfunction (NLUTD).

Materials and methods: Patients with NLUTD who received 200 IU onaBont-A injections were included in the study. Urodynamic parameters and the correlations between these parameters and treatment outcomes were analyzed. The primary endpoints were changes in the daily pad usage, and the secondary endpoint was to demonstrate the relationship between duration of treatment efficacy of onabotulinumtoxin-A with preoperative urodynamic parameters in patients with NLUTD.

Results: The data of 74 patients were analyzed retrospectively, and 66 (89%) patients benefited from onaBoNT-A treatment. A negative correlation was observed between the number of pads changed per day and maximum cystometric capacity (MCC) (p = 0.024, r = -0.277). A positive correlation existed between the duration of treatment efficacy of onaBoNT-A and change in detrusor pressure during filling cystometry (ΔPdet) (p = 0.018, r = 0.291), whereas a negative correlation was noted with bladder compliance (p = 0.035, r = -0.260). Any additional indicator of its urodynamic efficacy showing a correlation with the number of pads changed per day has not been identified yet.

Conclusion: OnaBoNT-A injections effectively manage NLUTD, with MCC being a potential predictor of treatment response. Other urodynamic parameters showed limited predictive value. Patients with lower MCC experienced greater improvements in reducing the number of pads used following treatment. High ΔPdet and low bladder compliance were associated with treatment benefits persisting for longer periods of time.

{"title":"Predictive Urodynamic Parameters for The Treatment Efficacy of Onabotulinum Toxin A in Neurogenic Lower Urinary Tract Dysfunction.","authors":"Muharrem Baturu, Ömer Bayrak, Yusuf Yaşar, Özlem Başgut, İlker Seçkiner","doi":"10.22037/uj.v22i.8289","DOIUrl":"https://doi.org/10.22037/uj.v22i.8289","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate urodynamic parameters that may serve as predictors of treatment efficacy with Onabotulinumtoxin-A (onaBoNT-A) in patients with neurogenic lower urinary tract dysfunction (NLUTD).</p><p><strong>Materials and methods: </strong>Patients with NLUTD who received 200 IU onaBont-A injections were included in the study. Urodynamic parameters and the correlations between these parameters and treatment outcomes were analyzed. The primary endpoints were changes in the daily pad usage, and the secondary endpoint was to demonstrate the relationship between duration of treatment efficacy of onabotulinumtoxin-A with preoperative urodynamic parameters in patients with NLUTD.</p><p><strong>Results: </strong>The data of 74 patients were analyzed retrospectively, and 66 (89%) patients benefited from onaBoNT-A treatment. A negative correlation was observed between the number of pads changed per day and maximum cystometric capacity (MCC) (p = 0.024, r = -0.277). A positive correlation existed between the duration of treatment efficacy of onaBoNT-A and change in detrusor pressure during filling cystometry (ΔPdet) (p = 0.018, r = 0.291), whereas a negative correlation was noted with bladder compliance (p = 0.035, r = -0.260). Any additional indicator of its urodynamic efficacy showing a correlation with the number of pads changed per day has not been identified yet.</p><p><strong>Conclusion: </strong>OnaBoNT-A injections effectively manage NLUTD, with MCC being a potential predictor of treatment response. Other urodynamic parameters showed limited predictive value. Patients with lower MCC experienced greater improvements in reducing the number of pads used following treatment. High ΔPdet and low bladder compliance were associated with treatment benefits persisting for longer periods of time.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":"22 2","pages":"95-101"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Plasmakinetic Resection and Conventional Transurethral Resection of the Prostate on Clinical Symptoms and Quality of Life in Patients with Benign Prostatic Hyperplasia: Retrospective Cohort Study.
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v22i.8330
Caoke Gong, Songnian Zou, Shouxi Cui

Purpose: Benign prostatic hyperplasia (BPH) is a condition commonly observed in elderly males, leading to lower urinary tract symptoms and potential complications. Surgical procedures primarily include transurethral resection of the prostate (TURP) and plasmakinetic resection, with their effectiveness under active research and clinical interest.

Materials and methods: This retrospective cohort study compared the impacts of plasmakinetic resection and conventional TURP on clinical symptoms and quality of life in patients with benign prostatic hyperplasia. It encompassed surgical duration, postoperative complications, urodynamic parameters, quality of life scores, sexual function, and long-term outcomes.

Results: Postoperative symptom improvements, including International Prostate Symptom Score (IPSS) and Quality of Life (QoL) score, were significantly higher in the plasmakinetic resection group (P = 0.033 and P = 0.003, respectively). Urodynamic parameters such as peak flow rate (P = 0.008), post-void residual volume (P = 0.044), and Qmax (P = 0.012) also showed significant improvements. Quality of life assessments, including (EuroQol-5 Dimensions)EQ-5D scores (P = 0.003), general health perception (P = 0.009), sexual function (P = 0.011), and overall satisfaction (P = 0.004) favored plasmakinetic resection. Plasmakinetic resection resulted in better outcomes for continence and sexual function. Long-term outcomes at 1 year post-operation, including IPSS scores (P = 0.006) and overall satisfaction (P = 0.002), were significantly better in the plasmakinetic resection group. No significant differences were observed in health care resource utilization.

Conclusion: The study suggests that plasmakinetic resection offers advantages over conventional TURP in symptom relief, quality of life, continence, sexual function, and long-term results for patients with BPH.

{"title":"The Impact of Plasmakinetic Resection and Conventional Transurethral Resection of the Prostate on Clinical Symptoms and Quality of Life in Patients with Benign Prostatic Hyperplasia: Retrospective Cohort Study.","authors":"Caoke Gong, Songnian Zou, Shouxi Cui","doi":"10.22037/uj.v22i.8330","DOIUrl":"https://doi.org/10.22037/uj.v22i.8330","url":null,"abstract":"<p><strong>Purpose: </strong>Benign prostatic hyperplasia (BPH) is a condition commonly observed in elderly males, leading to lower urinary tract symptoms and potential complications. Surgical procedures primarily include transurethral resection of the prostate (TURP) and plasmakinetic resection, with their effectiveness under active research and clinical interest.</p><p><strong>Materials and methods: </strong>This retrospective cohort study compared the impacts of plasmakinetic resection and conventional TURP on clinical symptoms and quality of life in patients with benign prostatic hyperplasia. It encompassed surgical duration, postoperative complications, urodynamic parameters, quality of life scores, sexual function, and long-term outcomes.</p><p><strong>Results: </strong>Postoperative symptom improvements, including International Prostate Symptom Score (IPSS) and Quality of Life (QoL) score, were significantly higher in the plasmakinetic resection group (P = 0.033 and P = 0.003, respectively). Urodynamic parameters such as peak flow rate (P = 0.008), post-void residual volume (P = 0.044), and Qmax (P = 0.012) also showed significant improvements. Quality of life assessments, including (EuroQol-5 Dimensions)EQ-5D scores (P = 0.003), general health perception (P = 0.009), sexual function (P = 0.011), and overall satisfaction (P = 0.004) favored plasmakinetic resection. Plasmakinetic resection resulted in better outcomes for continence and sexual function. Long-term outcomes at 1 year post-operation, including IPSS scores (P = 0.006) and overall satisfaction (P = 0.002), were significantly better in the plasmakinetic resection group. No significant differences were observed in health care resource utilization.</p><p><strong>Conclusion: </strong>The study suggests that plasmakinetic resection offers advantages over conventional TURP in symptom relief, quality of life, continence, sexual function, and long-term results for patients with BPH.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":"22 2","pages":"106-113"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erectile Dysfunction and Ejaculatory Dysfunction in Covid-19 Recovered Patient: Temporary or Persistent? Covid-19康复患者的勃起功能障碍和射精功能障碍:暂时的还是持续的?
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v21i.8113
Exsa Hadibrata, Sutyarso Sutyarso, Hendri Busman, Sumardi Sumardi

Purpose: Examine the prevalence of erectile dysfunction and ejaculatory dysfunction among COVID-19 recovered patients and whether this condition improved over time. The retrospective study of 50 male patients who have recovered from COVID-19 infection previously hospitalized in dr. H Abdul Moeloek General Hospital between March 2020 - March 2021.

Materials and methods: All of these patients were evaluated in terms of erectile and ejaculation function via phone interview. The International Index of Erectile Function 5 (IIEF-5) and Male sexual health questionnaire ejaculatory dysfunction (MHSQ-EJD) were used to assess the erectile function and ejaculatory dysfunction. Statistical analysis was performed to evaluate whether there was a difference between IIEF-5 & MHSQ-EJD scores within 6 months, 6 to 12 months, and >24 months after COVID-19 infection.

Results: The prevalence of ED was 70% and EJD was 2 % during 0-6 months after COVID-19 infection. Mean age and BMI were 50.4 ± 8.5 years and 23.6 ± 1.6 kg/m2 respectively. There are 26 patients (52%) had an educational background lower than bachelor's degree and 24 patients (48%) had an educational background of bachelor's degree or higher. It was reported that 4 patients (8%) had Diabetes Mellitus and 12 patients (24%) had Hypertension. Most were active smokers (74%) and 2 patients (4%) had reported as active alcohol drinkers. There was a statistically significant IIEF-5 scores difference between three periods of time (p <0,001).

Conclusion: The prevalence of Erectile Dysfunction was high in COVID-19 recovered patients. There was a temporary erectile dysfunction and ejaculatory dysfunction among COVID-19 patients.

目的:研究COVID-19康复患者勃起功能障碍和射精功能障碍的患病率,以及这种情况是否随着时间的推移而改善。对2020年3月至2021年3月期间曾在H Abdul Moeloek综合医院住院的50名COVID-19感染后康复的男性患者进行回顾性研究。材料和方法:通过电话访谈对所有患者的勃起和射精功能进行评估。采用国际勃起功能指数5 (IIEF-5)和男性性健康问卷射精功能障碍(MHSQ-EJD)对勃起功能和射精功能障碍进行评估。统计分析感染后6个月内、6 ~ 12个月内、24个月内IIEF-5和MHSQ-EJD评分是否存在差异。结果:新冠肺炎感染后0 ~ 6个月,ED患病率为70%,EJD为2%。平均年龄50.4±8.5岁,BMI为23.6±1.6 kg/m2。本科以下学历26例(52%),本科及以上学历24例(48%)。有糖尿病4例(8%),高血压12例(24%)。大多数患者是活跃吸烟者(74%),2例患者(4%)报告为活跃饮酒者。三个时间段的IIEF-5评分差异有统计学意义(p)。结论:新冠肺炎康复患者勃起功能障碍发生率较高。新冠肺炎患者存在暂时性勃起功能障碍和射精功能障碍。
{"title":"Erectile Dysfunction and Ejaculatory Dysfunction in Covid-19 Recovered Patient: Temporary or Persistent?","authors":"Exsa Hadibrata, Sutyarso Sutyarso, Hendri Busman, Sumardi Sumardi","doi":"10.22037/uj.v21i.8113","DOIUrl":"10.22037/uj.v21i.8113","url":null,"abstract":"<p><strong>Purpose: </strong>Examine the prevalence of erectile dysfunction and ejaculatory dysfunction among COVID-19 recovered patients and whether this condition improved over time. The retrospective study of 50 male patients who have recovered from COVID-19 infection previously hospitalized in dr. H Abdul Moeloek General Hospital between March 2020 - March 2021.</p><p><strong>Materials and methods: </strong>All of these patients were evaluated in terms of erectile and ejaculation function via phone interview. The International Index of Erectile Function 5 (IIEF-5) and Male sexual health questionnaire ejaculatory dysfunction (MHSQ-EJD) were used to assess the erectile function and ejaculatory dysfunction. Statistical analysis was performed to evaluate whether there was a difference between IIEF-5 & MHSQ-EJD scores within 6 months, 6 to 12 months, and >24 months after COVID-19 infection.</p><p><strong>Results: </strong>The prevalence of ED was 70% and EJD was 2 % during 0-6 months after COVID-19 infection. Mean age and BMI were 50.4 ± 8.5 years and 23.6 ± 1.6 kg/m2 respectively. There are 26 patients (52%) had an educational background lower than bachelor's degree and 24 patients (48%) had an educational background of bachelor's degree or higher. It was reported that 4 patients (8%) had Diabetes Mellitus and 12 patients (24%) had Hypertension. Most were active smokers (74%) and 2 patients (4%) had reported as active alcohol drinkers. There was a statistically significant IIEF-5 scores difference between three periods of time (p <0,001).</p><p><strong>Conclusion: </strong>The prevalence of Erectile Dysfunction was high in COVID-19 recovered patients. There was a temporary erectile dysfunction and ejaculatory dysfunction among COVID-19 patients.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"102-105"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic Management of the Urinary Stones.
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v22i.8456
Hamid Pakmanesh

Laparoscopic stone surgery was historically recommended only for cases involving concomitant ureteropelvic junction obstruction (UPJO), congenital abnormalities, or when other endourological procedures had failed as an alternative to open surgery. However, recent randomized clinical trials and meta-analyses involving patients with normal anatomy and large renal stones have shown that laparoscopic pyelolithotomy (LPL) has a higher success rate and lower complication rates compared to the gold standard, percutaneous nephrolithotomy (PCNL). Furthermore, stone recurrence appears to be lower following LPL compared to PCNL. Therefore, we suggest that current guidelines for stone treatment reconsider laparoscopy as an effective primary treatment for large kidney stones, rather than simply viewing it as an alternative option. Nonetheless, careful case selection and the surgeon's experience are critical for the success of this treatment.

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引用次数: 0
Ultra-mini Percutaneous Nephrolithotomy (UM-PCNL) with a Semi-rigid Ureteroscope in Preschool Children: An Innovative Experience in Southern Iran. 学龄前儿童超小型经皮肾镜碎石术(UM-PCNL):伊朗南部的创新经验。
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v21i.8084
Mohammad Mehdi Hosseini, Ali Eslahi, Fatemeh Masjedi, Sohail Ahmed, Seyed Sajjad Tabei, Mohammad Reza Abedini

Purpose: Percutaneous nephrolithotomy (PCNL) has undergone extensive modification to reduce complications. One of the recent advances in minimally invasive procedures is the advent of ultra-mini PCNL (UM-PCNL), which provides miniaturized access to the kidney. However, the specific instruments applied in UM-PCNL may not be found in centers with limited resources. This study evaluated the safety, feasibility, results, and short-term complication rates of performing UM-PCNL using a semi-rigid ureteroscope in preschool children.

Materials and methods: Between September 2013 and September 2021, a total of 68 patients, including 42 boys and 26 girls with a mean age of 3.2 ± 2.4 years, underwent UM-PCNL with a 4.5French tip ureteroscope instead of an ultra-mini nephroscope in children aged less than 7 years old. The procedure was done under general anesthesia in the prone position. The nephrostomy tract was dilated to 12F. Stones were fragmented using a pneumatic lithotripter. Irrigation was done with normal saline.

Results: The early stone-free rate (SFR) was 91%, and the short-term total SFR was 97%. No statistically significant difference was found in pre-operative and post-operative Hb, BUN, Cr, Na+, and K+. Fever (11 patients) and ileus (5 patients) constituted the majority of complications, and only one patient required a blood transfusion. None of the cases undergoing UM-PCNL with this method required a re-do PCNL.

Conclusion: Our experience shows that with sufficient experience in handling semi-rigid ureteroscopes, urologists practicing in centers with limited resources could perform UM-PCNL with relatively favorable outcomes.

目的:为减少并发症,经皮肾镜取石术(PCNL)进行了广泛的改良。微创手术的最新进展之一是超小型 PCNL(UM-PCNL)的出现,它提供了进入肾脏的微型通道。然而,在资源有限的中心可能找不到用于超微型 PCNL 的特定器械。本研究评估了在学龄前儿童中使用半硬质输尿管镜进行 UM-PCNL 的安全性、可行性、结果和短期并发症发生率:2013 年 9 月至 2021 年 9 月期间,共有 68 名 7 岁以下儿童接受了 UM-PCNL 手术,其中包括 42 名男孩和 26 名女孩,平均年龄(3.2±2.4)岁。手术在全身麻醉下以俯卧位进行。肾造瘘道扩张至 12F。使用气动碎石机碎石。结果:早期无石率(SFR)为 91%,短期总无石率为 97%。术前和术后的 Hb、BUN、Cr、Na+ 和 K+ 均无统计学差异。发热(11 名患者)和回肠梗阻(5 名患者)是大多数并发症,只有一名患者需要输血。采用这种方法进行 UM-PCNL 的病例无一需要再次进行 PCNL:我们的经验表明,在资源有限的中心执业的泌尿科医生只要在处理半硬性输尿管镜方面有足够的经验,就能实施 UM-PCNL,并取得相对较好的效果。
{"title":"Ultra-mini Percutaneous Nephrolithotomy (UM-PCNL) with a Semi-rigid Ureteroscope in Preschool Children: An Innovative Experience in Southern Iran.","authors":"Mohammad Mehdi Hosseini, Ali Eslahi, Fatemeh Masjedi, Sohail Ahmed, Seyed Sajjad Tabei, Mohammad Reza Abedini","doi":"10.22037/uj.v21i.8084","DOIUrl":"10.22037/uj.v21i.8084","url":null,"abstract":"<p><strong>Purpose: </strong>Percutaneous nephrolithotomy (PCNL) has undergone extensive modification to reduce complications. One of the recent advances in minimally invasive procedures is the advent of ultra-mini PCNL (UM-PCNL), which provides miniaturized access to the kidney. However, the specific instruments applied in UM-PCNL may not be found in centers with limited resources. This study evaluated the safety, feasibility, results, and short-term complication rates of performing UM-PCNL using a semi-rigid ureteroscope in preschool children.</p><p><strong>Materials and methods: </strong>Between September 2013 and September 2021, a total of 68 patients, including 42 boys and 26 girls with a mean age of 3.2 ± 2.4 years, underwent UM-PCNL with a 4.5French tip ureteroscope instead of an ultra-mini nephroscope in children aged less than 7 years old. The procedure was done under general anesthesia in the prone position. The nephrostomy tract was dilated to 12F. Stones were fragmented using a pneumatic lithotripter. Irrigation was done with normal saline.</p><p><strong>Results: </strong>The early stone-free rate (SFR) was 91%, and the short-term total SFR was 97%. No statistically significant difference was found in pre-operative and post-operative Hb, BUN, Cr, Na+, and K+. Fever (11 patients) and ileus (5 patients) constituted the majority of complications, and only one patient required a blood transfusion. None of the cases undergoing UM-PCNL with this method required a re-do PCNL.</p><p><strong>Conclusion: </strong>Our experience shows that with sufficient experience in handling semi-rigid ureteroscopes, urologists practicing in centers with limited resources could perform UM-PCNL with relatively favorable outcomes.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"68-74"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentially Expressed Blood ARLNC1 in Combination with PCA3/PSA has Reassuring Clinical Applications in the Early Diagnosis of Prostate Cancer in Iranians: A pilot study. 差异表达的血液 ARLNC1 与 PCA3/PSA 结合在伊朗人前列腺癌的早期诊断中具有可靠的临床应用价值:一项试点研究。
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v21i.8144
Nasser Simforoosh, Azadeh Arabi, Mahan Mohammadi, Farkhondeh Pouresmaeili, Bahman Jamali, Mehdi Azizmohammad Looha

Purpose: Prostate cancer (PCA) is the second most common malignancy in Western countries. Long non-coding RNAs are new markers in disease diagnosis. Our aim of this study was to investigate liquid biopsy biomarkers with high specificity and sensitivity for early diagnosis of PCA patients in Iran.

Materials and methods: Blood specimens were collected from 29 PCA, 32 benign prostate hyperplasia (BPH), and 29 control (CTRL) individuals. Real-time PCR analyzed expression amounts of PSA, ARLNC1, UCA1, and PCA3. The ROC curve (receiver operating characteristic curve) analysis evaluated the diagnostic power of the examined molecules for PCA.

Results: There was a significant upregulation of PCA3 in PCA and BPH groups compared to the controls (p values for PCA3=< 0.001 and BPH vs. CTRL = 0.0015) while there was no significant difference between PCA and BPH individuals. A significant upregulation of ARLNC1 was seen in BPH group compared to the controls (p value = 0.0042). Also, PCA3 expression level showed a significant relationship with prostate volume. There was no significant difference in UCA1 and PSA expression levels among the three groups (> 0.05). The PCA3/PSA ratio was significantly increased in PCA and BPH individuals vs. the CTRL group with high sensitivity and specificity. The gene expression of PCA3 and ARLNC1 in the BPH group showed a significant relationship with age.

Conclusion: Our findings showed that in the diagnosis of prostate cancer, measuring the expression of PCA3, PSA, and ARLNC1 genes is necessary to determine the health, benign, or cancerous status of patients' prostate. Also, selecting the PCA3/PSA ratio provides a new approach for diagnosing this cancer if confirmed in a larger clinical sample size and functional studies.

目的:前列腺癌(PCA)是西方国家第二大常见恶性肿瘤。长非编码 RNA 是疾病诊断的新标志物。我们这项研究的目的是调查具有高特异性和高灵敏度的液体生物标记物,以用于伊朗 PCA 患者的早期诊断:收集了 29 名 PCA 患者、32 名良性前列腺增生症(BPH)患者和 29 名对照组(CTRL)患者的血液标本。实时 PCR 分析了 PSA、ARLNC1、UCA1 和 PCA3 的表达量。ROC曲线(接收者操作特征曲线)分析评估了所研究分子对PCA的诊断能力:结果:与对照组相比,PCA3在PCA组和良性前列腺增生组中明显上调(PCA3=< 0.001,良性前列腺增生组与对照组相比=0.0015),而PCA组和良性前列腺增生组之间没有明显差异。与对照组相比,良性前列腺增生组的 ARLNC1 明显上调(p 值=0.0042)。此外,PCA3 的表达水平与前列腺体积也有显著关系。三组间 UCA1 和 PSA 表达水平无明显差异(>0.05)。PCA3/PSA 比值在 PCA 组和 BPH 组与 CTRL 组相比明显升高,具有较高的敏感性和特异性。良性前列腺增生组中PCA3和ARLNC1的基因表达与年龄有明显关系:我们的研究结果表明,在前列腺癌的诊断中,测量 PCA3、PSA 和 ARLNC1 基因的表达对确定患者前列腺的健康、良性或癌症状态非常必要。此外,如果在更大的临床样本量和功能研究中得到证实,选择 PCA3/PSA 比值为诊断前列腺癌提供了一种新方法。
{"title":"Differentially Expressed Blood ARLNC1 in Combination with PCA3/PSA has Reassuring Clinical Applications in the Early Diagnosis of Prostate Cancer in Iranians: A pilot study.","authors":"Nasser Simforoosh, Azadeh Arabi, Mahan Mohammadi, Farkhondeh Pouresmaeili, Bahman Jamali, Mehdi Azizmohammad Looha","doi":"10.22037/uj.v21i.8144","DOIUrl":"10.22037/uj.v21i.8144","url":null,"abstract":"<p><strong>Purpose: </strong>Prostate cancer (PCA) is the second most common malignancy in Western countries. Long non-coding RNAs are new markers in disease diagnosis. Our aim of this study was to investigate liquid biopsy biomarkers with high specificity and sensitivity for early diagnosis of PCA patients in Iran.</p><p><strong>Materials and methods: </strong>Blood specimens were collected from 29 PCA, 32 benign prostate hyperplasia (BPH), and 29 control (CTRL) individuals. Real-time PCR analyzed expression amounts of PSA, ARLNC1, UCA1, and PCA3. The ROC curve (receiver operating characteristic curve) analysis evaluated the diagnostic power of the examined molecules for PCA.</p><p><strong>Results: </strong>There was a significant upregulation of PCA3 in PCA and BPH groups compared to the controls (p values for PCA3=< 0.001 and BPH vs. CTRL = 0.0015) while there was no significant difference between PCA and BPH individuals. A significant upregulation of ARLNC1 was seen in BPH group compared to the controls (p value = 0.0042). Also, PCA3 expression level showed a significant relationship with prostate volume. There was no significant difference in UCA1 and PSA expression levels among the three groups (> 0.05). The PCA3/PSA ratio was significantly increased in PCA and BPH individuals vs. the CTRL group with high sensitivity and specificity. The gene expression of PCA3 and ARLNC1 in the BPH group showed a significant relationship with age.</p><p><strong>Conclusion: </strong>Our findings showed that in the diagnosis of prostate cancer, measuring the expression of PCA3, PSA, and ARLNC1 genes is necessary to determine the health, benign, or cancerous status of patients' prostate. Also, selecting the PCA3/PSA ratio provides a new approach for diagnosing this cancer if confirmed in a larger clinical sample size and functional studies.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"75-82"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved Graft Function and Decreased Post-transplantation Urinary Tract Infection after Azithromycin Dosing to Donors: A Pilot Study.
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v22i.7988
Mojtaba Teimoori, Gholamreza Mokhtari, Siavash Falahatkar, Masoud Khosravi, Majid Momeni Moghaddam, Zahra Taheri

Purpose: The rising trend of End-stage Renal Disease (ESRD) patients requiring dialysis or transplantation needs a more therapeutic plan. As the best strategy for ESRD patients, kidney transplantation still needs outcome improvement. Macrolide drugs display antimicrobial and anti-inflammatory properties in chronic disease and intraoperatively and can concentrate in tissues for extended periods. Hence, theoretically, the drug prescription to the donor and accumulation in the kidney can cause graft immunomodulation and improve kidney transplantation outcomes.

Methods and analysis: This double-blinded randomized clinical trial was conducted on 62 eligible kidney donors randomly allocated to the azithromycin or placebo group and treated with a single dose (one gram) one day before surgery. The primary outcome was kidney graft function, and secondary outcomes included rejection rate, urinary tract infections in graft recipients, pain and systemic inflammatory response syndrome in live donors, and complications in donors and recipients. Outcomes were measured at baseline and every day in the first week after transplantation in both live donors and recipients and 30 and 90 days after transplantation. The adverse events were recorded as well.

Result: The mean age was 39 (SD, 13) years; 40% were women, and 11.6% were diabetic. Mean creatinine was 6.11 mL/min/1.73m2. Most patients in both arms were male (61.3%) and in early middle age. Hypertension was the most common cause of ESRD. Azithromycin could reduce the rejection rate in the first few days after kidney transplantation. Inflammatory mediators were lower in the azithromycin group, and fewer cases of urinary tract infection were found in the azithromycin group (p < 0.05).

Conclusion: Azithromycin reduces adverse outcomes and enhances graft function. It would offer an intervention that is easy to use and economical, lowering post-transplant risks.

{"title":"Improved Graft Function and Decreased Post-transplantation Urinary Tract Infection after Azithromycin Dosing to Donors: A Pilot Study.","authors":"Mojtaba Teimoori, Gholamreza Mokhtari, Siavash Falahatkar, Masoud Khosravi, Majid Momeni Moghaddam, Zahra Taheri","doi":"10.22037/uj.v22i.7988","DOIUrl":"https://doi.org/10.22037/uj.v22i.7988","url":null,"abstract":"<p><strong>Purpose: </strong>The rising trend of End-stage Renal Disease (ESRD) patients requiring dialysis or transplantation needs a more therapeutic plan. As the best strategy for ESRD patients, kidney transplantation still needs outcome improvement. Macrolide drugs display antimicrobial and anti-inflammatory properties in chronic disease and intraoperatively and can concentrate in tissues for extended periods. Hence, theoretically, the drug prescription to the donor and accumulation in the kidney can cause graft immunomodulation and improve kidney transplantation outcomes.</p><p><strong>Methods and analysis: </strong>This double-blinded randomized clinical trial was conducted on 62 eligible kidney donors randomly allocated to the azithromycin or placebo group and treated with a single dose (one gram) one day before surgery. The primary outcome was kidney graft function, and secondary outcomes included rejection rate, urinary tract infections in graft recipients, pain and systemic inflammatory response syndrome in live donors, and complications in donors and recipients. Outcomes were measured at baseline and every day in the first week after transplantation in both live donors and recipients and 30 and 90 days after transplantation. The adverse events were recorded as well.</p><p><strong>Result: </strong>The mean age was 39 (SD, 13) years; 40% were women, and 11.6% were diabetic. Mean creatinine was 6.11 mL/min/1.73m2. Most patients in both arms were male (61.3%) and in early middle age. Hypertension was the most common cause of ESRD. Azithromycin could reduce the rejection rate in the first few days after kidney transplantation. Inflammatory mediators were lower in the azithromycin group, and fewer cases of urinary tract infection were found in the azithromycin group (p < 0.05).</p><p><strong>Conclusion: </strong>Azithromycin reduces adverse outcomes and enhances graft function. It would offer an intervention that is easy to use and economical, lowering post-transplant risks.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":"22 2","pages":"89-94"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tele-urology in the Era of COVID-19: An Experience of the Reconstructive Urology Department in Iran. COVID-19 时代的远程泌尿外科:伊朗泌尿外科整形部门的经验。
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v20i.8096
Jalil Hosseini, Amir Hossein Eslami, Shahrzad Nematollahi, Rayka Sharifian, Arezoo Sheikh Milani, Alireza Fatemi

None.

引言冠状病毒的爆发给许多国家的医疗保健系统带来了额外的压力;但远程医疗可以成为应对这一问题的重要途径,尤其是对那些健康受到病毒影响的人而言。本研究旨在调查远程泌尿外科重建转诊计划的实施情况:材料和方法:所有在去年接受过尿道重建手术的患者都被纳入我们的研究中,两名护士收集了患者的人口统计学和既往病史数据。电话访问:泌尿整形外科研究员通过电话与患者取得联系,并填写 USS-PROM 和 COVID-19 问卷。面对面访问:所有患者均被要求回答有关近期接触和感染科罗娜病毒、近期旅行和其他 COVID-19 危险因素的问卷:USSPROM量表的平均值为1.65(+2.91),范围为0-15。根据 USSPROM 量表的分类,74 名患者(94.8%)症状轻微,4 名患者(5.1%)症状中度,需要进一步就医。4名USSPROM评分为中度的患者需要进行膀胱镜评估,其中1名USSPROM评分为中度的患者有严重的尿道狭窄,需要重新进行尿道成形术。另外两名患者需要进行尿道狭窄扩张术。费用根据出租车服务费计算。因此,亲自去看医生的平均费用(+SD)估计为 480+432 万里亚尔。就距离而言,根据患者居住地区,接受医疗服务的平均距离为 373.2 +348.79 公里。就患者对虚拟检查的看法而言,虚拟就诊不适合体检、患者无法正确解释问题、虚拟就诊时患者的状况是受访者报告的主要挑战:考虑到目前的 COVID-19 紧急情况可能会持续数月,远程医疗可能是为大部分患者提供泌尿科护理的最安全方式,例如那些更有可能出现 COVID-19 不良后果的患者。
{"title":"Tele-urology in the Era of COVID-19: An Experience of the Reconstructive Urology Department in Iran.","authors":"Jalil Hosseini, Amir Hossein Eslami, Shahrzad Nematollahi, Rayka Sharifian, Arezoo Sheikh Milani, Alireza Fatemi","doi":"10.22037/uj.v20i.8096","DOIUrl":"10.22037/uj.v20i.8096","url":null,"abstract":"<p><p>None.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"114-115"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epididimal Cyst in Children: A Single-Institutional Experience. 儿童表皮囊肿:一家医院的经验。
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-03-02 DOI: 10.22037/uj.v21i.8003
Onursal Varlikli, Mustafa Alper Akay, Semih Metin, Mehmet Akif Cankorur, Yonca Anik

Purpose: Simple epididymal cysts (EC) are rare in childhood and are mostly diagnosed at puberty. Although there is no consensus on the treatment, a conservative approach is generally preferred. To evaluate patients diagnosed with EC at our clinic in terms of presenting symptoms, diagnosis, and treatment methods.

Materials and methods: Data of patients treated for epididymal cysts at our institution between March 2012 and March 2023 were retrospectively analyzed in terms of age, symptomatology, diagnostic method, treatment method, and outcomes. In all cases, the diagnosis of EC was based on physical examination with scrotal ultrasonography (US) confirmation.

Results: A total of 1829 patients underwent scrotal Doppler US, and EC was detected in 72 patients (10.7%). The median follow-up period of the 43 patients was 21.7 (6-80 months). Of these, 9 were bilateral (12.5%). The mean age of the patients at presentation was 14.8 years. Forty-one patients had scrotal pain, 12 had scrotal swelling, and 19 incidentally had EC. The cysts were between 1.2- 37 mm. Only 3 (4.1%) patients required surgical excision due to persistent pain.

Conclusion: EC is a benign lesion, and treatment approaches are usually conservative. Surgical excision is recommended for patients with persistent scrotal pain or an acute scrotum.

目的:单纯性附睾囊肿(EC)在儿童期很少见,大多在青春期确诊。虽然对治疗方法尚未达成共识,但一般倾向于保守治疗。本研究旨在评估本诊所确诊的附睾囊肿患者的症状、诊断和治疗方法:回顾性分析 2012 年 3 月至 2023 年 3 月期间在我院接受治疗的附睾囊肿患者的年龄、症状、诊断方法、治疗方法和结果。所有病例的睾丸囊肿诊断均基于体格检查和阴囊超声检查(US)确诊:结果:共有 1829 名患者接受了阴囊多普勒超声检查,其中 72 名患者(10.7%)被发现患有阴囊癌。43 名患者的中位随访时间为 21.7 个月(6-80 个月)。其中,9 例为双侧患者(12.5%)。患者发病时的平均年龄为 14.8 岁。41名患者有阴囊疼痛,12名患者有阴囊肿胀,19名患者偶然发现了EC。囊肿大小在1.2-37毫米之间。只有3例(4.1%)患者因持续疼痛而需要手术切除:EC是一种良性病变,治疗方法通常比较保守。结论:阴囊癌是一种良性病变,治疗方法通常为保守治疗,建议对阴囊持续疼痛或阴囊急性疼痛的患者进行手术切除。
{"title":"Epididimal Cyst in Children: A Single-Institutional Experience.","authors":"Onursal Varlikli, Mustafa Alper Akay, Semih Metin, Mehmet Akif Cankorur, Yonca Anik","doi":"10.22037/uj.v21i.8003","DOIUrl":"10.22037/uj.v21i.8003","url":null,"abstract":"<p><strong>Purpose: </strong>Simple epididymal cysts (EC) are rare in childhood and are mostly diagnosed at puberty. Although there is no consensus on the treatment, a conservative approach is generally preferred. To evaluate patients diagnosed with EC at our clinic in terms of presenting symptoms, diagnosis, and treatment methods.</p><p><strong>Materials and methods: </strong>Data of patients treated for epididymal cysts at our institution between March 2012 and March 2023 were retrospectively analyzed in terms of age, symptomatology, diagnostic method, treatment method, and outcomes. In all cases, the diagnosis of EC was based on physical examination with scrotal ultrasonography (US) confirmation.</p><p><strong>Results: </strong>A total of 1829 patients underwent scrotal Doppler US, and EC was detected in 72 patients (10.7%). The median follow-up period of the 43 patients was 21.7 (6-80 months). Of these, 9 were bilateral (12.5%). The mean age of the patients at presentation was 14.8 years. Forty-one patients had scrotal pain, 12 had scrotal swelling, and 19 incidentally had EC. The cysts were between 1.2- 37 mm. Only 3 (4.1%) patients required surgical excision due to persistent pain.</p><p><strong>Conclusion: </strong>EC is a benign lesion, and treatment approaches are usually conservative. Surgical excision is recommended for patients with persistent scrotal pain or an acute scrotum.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"83-88"},"PeriodicalIF":1.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual Functions in Men with Congenital Bilateral Absence of the Vas Deferens: A Retrospective Cross-sectional Study with Fertile Men. 先天性双侧输精管缺失男性的性功能:对有生育能力男性的回顾性横断面研究。
IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-12 DOI: 10.22037/uj.v21i.8242
Emre Can Akinsal, Numan Baydilli, Halil Tosun, Emrah Kızılay, Gökhan Sönmez

Purpose: To examine the sexual and psychological conditions of men with Bilateral Congenital Bilateral Absence of the Vas Deferens (CBAVD), a rare condition that contributes to male infertility, and compare it with healthy fertile men.

Material and methods: A total of 52 patients with CBAVD and 66 healthy, fertile men who attended our infertility and andrology clinic were included in the study. Patients with cognitive impairments, language barriers, significant comorbidities, or a history of urogenital surgery were excluded. Reproductive hormone levels and semen volumes were evaluated. In addition, sexual status was investigated with validated questionnaires such as the International Index of Erectile Function, Male Sexual Health Questionnaire, Arabic Index of Premature Ejaculation, Premature Ejaculation Diagnostic Tool, and Premature Ejaculation Profile.

Results: In the CBAVD group, median total testosterone, FSH, LH levels, and semen volume were 401 ng/dL, 3.9 mIU/ml, 3.9 mIU/ml, and 0.9 ml, respectively. These parameters were 376 (ng/dL), 4.8 mIU/ml, 5 mIU/ml, and 3 ml in the control group. Semen volume was significantly lower in CBAVD men (p < 0.001). Questionnaires assessing erectile and ejaculatory function have shown that there was no significant difference between the CBAVD and control groups in terms of erectile function, orgasmic function, and sexual relationship satisfaction. However, sexual desire (p = 0.006) and overall satisfaction (p = 0.028) were found to be higher in the CBAVD group.

Conclusion: The study suggests that CBAVD may not be a direct etiological factor for erectile dysfunction or premature ejaculation.

目的:研究导致男性不育的罕见疾病--先天性双侧输精管缺如(CBAVD)男性患者的性和心理状况,并将其与健康可育男性进行比较:研究对象包括 52 名先天性双侧输精管缺如患者和 66 名在本院不孕不育和泌尿科门诊就诊的健康可育男性。排除了有认知障碍、语言障碍、严重合并症或泌尿生殖系统手术史的患者。对生殖激素水平和精液量进行了评估。此外,还使用国际勃起功能指数、男性性健康问卷、阿拉伯早泄指数、早泄诊断工具和早泄档案等有效问卷调查性功能状况:在 CBAVD 组中,总睾酮、FSH、LH 水平和精液量的中位数分别为 401 ng/dL、3.9 mIU/ml、3.9 mIU/ml 和 0.9 ml。对照组的这些参数分别为 376(纳克/分升)、4.8 mIU/ml、5 mIU/ml 和 3 毫升。 CBAVD男性的精液量明显较低(p< 0.001)。评估勃起和射精功能的问卷调查显示,在勃起功能、性高潮功能和性关系满意度方面,CBAVD 组和对照组没有明显差异。然而,CBAVD 组的性欲(p=0.006)和总体满意度(p=0.028)较高:研究表明,CBAVD 可能不是勃起功能障碍或早泄的直接病因。
{"title":"Sexual Functions in Men with Congenital Bilateral Absence of the Vas Deferens: A Retrospective Cross-sectional Study with Fertile Men.","authors":"Emre Can Akinsal, Numan Baydilli, Halil Tosun, Emrah Kızılay, Gökhan Sönmez","doi":"10.22037/uj.v21i.8242","DOIUrl":"10.22037/uj.v21i.8242","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the sexual and psychological conditions of men with Bilateral Congenital Bilateral Absence of the Vas Deferens (CBAVD), a rare condition that contributes to male infertility, and compare it with healthy fertile men.</p><p><strong>Material and methods: </strong>A total of 52 patients with CBAVD and 66 healthy, fertile men who attended our infertility and andrology clinic were included in the study. Patients with cognitive impairments, language barriers, significant comorbidities, or a history of urogenital surgery were excluded. Reproductive hormone levels and semen volumes were evaluated. In addition, sexual status was investigated with validated questionnaires such as the International Index of Erectile Function, Male Sexual Health Questionnaire, Arabic Index of Premature Ejaculation, Premature Ejaculation Diagnostic Tool, and Premature Ejaculation Profile.</p><p><strong>Results: </strong>In the CBAVD group, median total testosterone, FSH, LH levels, and semen volume were 401 ng/dL, 3.9 mIU/ml, 3.9 mIU/ml, and 0.9 ml, respectively. These parameters were 376 (ng/dL), 4.8 mIU/ml, 5 mIU/ml, and 3 ml in the control group. Semen volume was significantly lower in CBAVD men (p < 0.001). Questionnaires assessing erectile and ejaculatory function have shown that there was no significant difference between the CBAVD and control groups in terms of erectile function, orgasmic function, and sexual relationship satisfaction. However, sexual desire (p = 0.006) and overall satisfaction (p = 0.028) were found to be higher in the CBAVD group.</p><p><strong>Conclusion: </strong>The study suggests that CBAVD may not be a direct etiological factor for erectile dysfunction or premature ejaculation.</p>","PeriodicalId":23416,"journal":{"name":"Urology Journal","volume":" ","pages":"44-49"},"PeriodicalIF":1.5,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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