Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666230816160700
Viviane Amaral-Carvalho, Thais Bento Lima-Silva, Luciano Inácio Mariano, Leonardo Cruz de Souza, Henrique Cerqueira Guimarães, Valeria Santoro Bahia, Ricardo Nitrini, Maira Tonidandel Barbosa, Mônica Sanches Yassuda, Paulo Caramelli
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Abstract

Background: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are important causes of dementia with challenging differential diagnoses in many cases. Addenbrooke's Cognitive Examination-Revised (ACE-R) is a cognitive battery that may be useful to differentiate the two disorders.

Objective: The objectibe of this study is to investigate the value of the ACE-R combined with sociodemographic factors in the differential diagnosis between AD and bvFTD.

Methods: The ACE-R was administered to 102 patients with mild dementia due to probable AD, 37 with mild bvFTD, and 135 controls. Performances of patients and controls were analyzed by logistic regression and by ROC curves to refine the diagnostic accuracy of the ACE-R in AD and bvFTD.

Results: The ACE-R subscores Attention and Orientation, Fluency, and Memory, in combination with schooling differentiated AD from controls with an area under the ROC curve (AUC) of 0.936 (86% sensitivity and 87% specificity). The ACE-R subscores Attention and Orientation, Fluency, and Language, in combination with sex (male), age, and schooling, discriminated bvFTD from controls with an AUC of 0.908 (81% sensitivity and 95% specificity). In the differentiation between AD and bvFTD, the ACE-R subscores Attention and Orientation, Fluency, and Language, together with age, displayed an AUC of 0.865 (78% sensitivity and 85% specificity).

Conclusion: The combination of ACE-R scores with sociodemographic data allowed good differentiation between AD and bvFTD in the study sample.

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使用Addenbrooke认知检查修正子核与社会形态因素相结合的算法预测阿尔茨海默病和行为变异性额颞叶痴呆引起的痴呆。
背景:阿尔茨海默病(AD)和行为变异性额颞叶痴呆(bvFTD)是痴呆的重要原因,在许多情况下具有挑战性的鉴别诊断。Addenbrooke的认知检查修订版(ACE-R)是一种认知电池,可能有助于区分这两种疾病。目的:本研究的目的是探讨ACE-R与社会人口学因素在AD和bvFTD鉴别诊断中的价值。通过逻辑回归和ROC曲线分析患者和对照组的表现,以提高ACE-R在AD和bvFTD中的诊断准确性。ACE-R分量表注意力和方向、流利程度和语言,结合性别(男性)、年龄和学校教育,将FTD与对照组区分开来,AUC为0.908(81%的敏感性和95%的特异性)。在AD和bvFTD之间的区分中,ACE-R分量表注意力和方向、流利度和语言以及年龄显示出0.865的AUC(78%的敏感性和85%的特异性)。结论:将ACE-R评分与社会人口学数据相结合,可以很好地区分研究样本中的AD和bfFTD。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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