Associations of attention-deficit/hyperactivity disorder with inflammatory diseases. Results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS).

IF 1.1 Q4 PSYCHIATRY NEUROPSYCHIATRIE Pub Date : 2024-12-01 Epub Date: 2023-08-17 DOI:10.1007/s40211-023-00479-8

Lena Boemanns, Julia Staab, Thomas Meyer

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Abstract

Background: Despite conflicting data, some studies have suggested a pathophysiological relationship between inflammation and attention-deficit/hyperactivity disorder (ADHD).

Methods: Using data from the nationwide and representative German Health Interview and Examination Survey for Children and Adolescents (KiGGS; n = 6922 study participants aged 11-17 years), this post hoc analysis assessed the associations between ADHD and three common inflammatory diseases.

Results: Results showed univariate associations between ADHD and lifetime inflammatory diseases including atopic dermatitis (p = 0.002), otitis media (p = 0.001), and herpes simplex infection (p = 0.032). In logistic regression models adjusted for clinically relevant confounders, we found that ADHD remained a significant predictor of all three inflammatory diseases (atopic dermatitis, Exp(β) = 1.672, 95% confidence interval [CI] 1.239-2.257, p = 0.001; otitis media, Exp(β) = 1.571, 95% CI 1.209-2.040, p = 0.001; herpes simplex, Exp(β) = 1.483, 95% CI 1.137-1.933, p = 0.004).

Conclusion: Our findings demonstrate a positive link between ADHD and peripheral inflammatory diseases, including atopic dermatitis, otitis media, and herpes simplex infection. Further studies are needed to understand the exact pathophysiological mechanisms underlying these associations.

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注意缺陷/多动症与炎症性疾病的关系。德国全国儿童和青少年健康访谈和检查调查（KiGGS）的结果。

背景：尽管数据相互矛盾，但一些研究表明炎症与注意力缺陷/多动症（ADHD）之间存在病理生理关系：尽管数据相互矛盾，但一些研究表明炎症与注意力缺陷/多动症（ADHD）之间存在病理生理关系：方法：利用具有全国代表性的德国儿童和青少年健康访谈和检查调查（KiGGS；n = 6922 名 11-17 岁的研究参与者）的数据，进行事后分析，评估多动症与三种常见炎症之间的关系：结果显示，多动症与终生炎症性疾病（包括特应性皮炎（p = 0.002）、中耳炎（p = 0.001）和单纯疱疹病毒感染（p = 0.032））之间存在单变量关联。在调整了临床相关混杂因素的逻辑回归模型中，我们发现多动症仍然是所有三种炎症性疾病的重要预测因素（异位性皮炎，Exp(β) = 1.672，95% 置信区间 [CI] 1.239-2.257，p = 0.001；中耳炎，Exp(β) = 1.571，95% CI 1.209-2.040，p = 0.001；单纯疱疹，Exp(β) = 1.483，95% CI 1.137-1.933，p = 0.004）：我们的研究结果表明，多动症与特应性皮炎、中耳炎和单纯疱疹感染等外周炎症性疾病之间存在正相关。要了解这些关联的确切病理生理机制，还需要进一步的研究。

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NEUROPSYCHIATRIE PSYCHIATRY-

CiteScore

3.80

自引率

20.00%

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期刊介绍： Die Zeitschrift ist das offizielle Organ der „Österreichischen Gesellschaft für Psychiatrie, Psychotherapie und Psychosomatik (ÖGPP)'', und wissenschaftliches Organ der Österreichischen Alzheimer Gesellschaft, der Österreichischen Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie, der Österreichischen Schizophreniegesellschaft, und der pro mente austria - Österreichischer Dachverband der Vereine und Gesellschaften für psychische und soziale Gesundheit.Sie veröffentlicht Übersichten zu relevanten Themen des Fachs, Originalarbeiten, Kasuistiken sowie Briefe an die Herausgeber. Zudem wird auch Buchbesprechungen sowie Neuigkeiten aus den Bereichen Personalia, Standes- und Berufspolitik sowie Kongressankündigungen Raum gewidmet.Thematisch ist das Fach Psychiatrie und die Methoden der Psychotherapie in allen ihren Facetten vertreten. Die Zeitschrift richtet sich somit an alle Berufsgruppen, die sich mit Ursachen, Erscheinungsformen und Behandlungsmöglichkeiten von psychischen Störungen beschäftigen. -----------------------------------------------------------------------------------------------------· The professional and educational journal of the Austrian Society of Psychiatry, Psychotherapy and Psychosomatics (Österreichische Gesellschaft für Psychiatrie, Psychotherapie und Psychosomatik; ÖGPP) and the Austrian Society of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (Österreichische Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie; ÖGKJP)· Overviews of all relevant topics pertaining to the discipline· Intended for all occupational groups committed to the causes and manifestations of, as well as therapy options for psychic disorders· All manuscripts principally pass through a double-blind peer review process involving at least two independent expertsThe official journal of the Austrian Societies of Psychiatry, Psychotherapy and Psychosomatics (ÖGPP) and Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (ÖGKJP)The journal publishes overviews of relevant issues in the field, original work, case reports and letters to the editors. In addition, space is devoted to book reviews, news from the areas of personnel matters and professional policies, and conference announcements.Thematically, the discipline of psychiatry and the methods of psychotherapy are represented in all their facets. The journal is thus aimed at all professional groups committed to the causes and manifestations of, as well as therapy options for psychic disorders

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