Comorbidities in Patients with Lichen Planopilaris: A Case-Control Study.

IF 1.3 Q3 DERMATOLOGY Skin Appendage Disorders Pub Date : 2022-07-01 Epub Date: 2022-03-09 DOI:10.1159/000522371

Maryam Nasimi, Gholamreza Garmaroudi, Maryam Ghiasi, Vahideh Lajevardi, Zahra Fooladi, Mahgol Sadat Hassan Zadeh Tabatabaei, Mahshid Sadat Ansari

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Abstract

Introduction: Lichen planopilaris (LPP) is a lymphocyte-mediated type of scarring alopecia and considered to have autoimmune etiology. Studies about systemic comorbid conditions are limited. Our goal is to identify the prevalence of medical comorbidities in patients with LPP.

Methods: In a retrospective case-control study, the medical records of 208 LPP patients and 208 controls were reviewed for existing comorbidities such as thyroid diseases, cardiovascular disorders, hypertension, hyperlipidemia, and lupus erythematous.

Results: Hyperlipidemia was found in 41.8% of all patients with LPP and in 17.3% of controls (p value <0.001, OR = 4.167). Chances of hypertension and cardiovascular disorders were lower in the LPP group in comparison to controls (p value = 0.009). Thyroid disorders were more prevalent in LPP patients, but the difference was not statistically significant (p value = 0.277).

Conclusion: Our study further emphasizes that LPP patients should be screened for medical comorbidities, especially lipid profile abnormalities.

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扁平苔藓患者的合并症：病例对照研究

简介扁平苔癣（LPP）是一种淋巴细胞介导的瘢痕性脱发，被认为是自身免疫性病因。有关全身合并症的研究十分有限。我们的目标是确定 LPP 患者合并症的发病率：在一项回顾性病例对照研究中，我们查阅了 208 名 LPP 患者和 208 名对照组患者的病历，以了解他们是否患有甲状腺疾病、心血管疾病、高血压、高脂血症和红斑狼疮等合并症：41.8%的红斑狼疮患者患有高脂血症，17.3%的对照组患者患有高脂血症（P值=0.009）。甲状腺疾病在 LPP 患者中更为普遍，但差异无统计学意义（P 值 = 0.277）：我们的研究进一步强调，应筛查 LPP 患者的合并症，尤其是血脂异常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Appendage Disorders DERMATOLOGY-

CiteScore

2.00

自引率

10.00%

发文量