Skin Appendage Disorders最新文献

Background: Scalp discoid lupus erythematosus in Caucasians is still a rare disease with a variable clinical presentation. Its dermoscopic characteristics are poorly described in literature, especially in the white population. The aim of this review was to critically analyze published papers on this topic and summarize relevant features.

Summary: A comprehensive search for eligible articles was conducted in the databases of MEDLINE/PubMed. Results were analyzed following dermoscopic patterns such as follicular openings, hair shafts, perifollicular surface, and vessel pattern.

Key messages: The most representative features appeared the absence of follicular openings and the presence of follicular keratotic plugs, along with yellow-brown and red dots. In long-lasting lesions with chronic stage, trichoscopy showed the absence of follicular openings, white or milky red cicatricial patches, white and brown structureless areas, and thick arborizing vessels.

Introduction: Oral finasteride and topical minoxidil are long-standing androgenetic alopecia (AGA) treatments; topical finasteride is a more recent medicine. Few studies have compared their therapeutic effects in postmenopausal women. We compared the therapeutic impact of topical finasteride (1-4 sprays of 0.25% topical finasteride solution daily for 12 months), oral finasteride (2.5 mg oral finasteride once daily for 12 months), and topical minoxidil (1 mL of topical minoxidil 5% twice daily for 12 months) in postmenopausal women with AGA.

Methods: We conducted Bayesian network meta-analyses of individual patient-level data insofar as four clinically relevant endpoints, namely, 12-month change in (1) total hair density, (2) hair diameter, (3) clinical photographs, and (4) patients' opinion of efficacy. Data were obtained through medical charts. Regimens' surface under the cumulative ranking distribution (SUCRA) values and relative effects - as per odds ratios - were computed.

Results: As per SUCRA, the most and least effective regimens - across the four outcomes - were oral finasteride, and topical finasteride, respectively; however, no significant statistical differences were found (i.e., p > 0.05).

Conclusion: Oral finasteride is ranked more effective than the topical forms of minoxidil and finasteride; however, more studies are needed to confirm this result.

[This corrects the article DOI: 10.1159/000538581.].

[This corrects the article DOI: 10.1159/000517831.].

[This corrects the article DOI: 10.1159/000528658.].

[This corrects the article DOI: 10.1159/000533796.].

Background: Squamous cell carcinoma (SCC) and SCC in situ (Bowen's disease) are the most common malignancies of the nail unit. They are frequently seen in men over 50 and most commonly affect the fingers. The role of high-risk human papillomavirus (HPV) infection has been identified as a key contributor to the development of nail unit SCC.

Summary: In this review, we aimed to summarize the current state of our understanding of how HPV contributes to nail unit SCC, the role of genitodigital transmission of HPV, and the clinical features of HPV-associated nail unit SCC. We also review current advances in the treatment of nail unit SCC, with a focus on the potential role of HPV vaccination in the treatment and prevention of nail unit SCC.

Key messages: Nail unit SCC should be recognized as an HPV-associated disease. HPV vaccination may represent a non-surgical modality for the management of these challenging malignancies in the appropriate clinical setting.