Extensive topographic remapping and functional sharpening in the adult rat visual pathway upon first visual experience.

IF 7.8 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY PLoS Biology Pub Date : 2023-08-17 eCollection Date: 2023-08-01 DOI:10.1371/journal.pbio.3002229
Joana Carvalho, Francisca F Fernandes, Noam Shemesh
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Abstract

Understanding the dynamics of stability/plasticity balances during adulthood is pivotal for learning, disease, and recovery from injury. However, the brain-wide topography of sensory remapping remains unknown. Here, using a first-of-its-kind setup for delivering patterned visual stimuli in a rodent magnetic resonance imaging (MRI) scanner, coupled with biologically inspired computational models, we noninvasively mapped brain-wide properties-receptive fields (RFs) and spatial frequency (SF) tuning curves-that were insofar only available from invasive electrophysiology or optical imaging. We then tracked the RF dynamics in the chronic visual deprivation model (VDM) of plasticity and found that light exposure progressively promoted a large-scale topographic remapping in adult rats. Upon light exposure, the initially unspecialized visual pathway progressively evidenced sharpened RFs (smaller and more spatially selective) and enhanced SF tuning curves. Our findings reveal that visual experience following VDM reshapes both structure and function of the visual system and shifts the stability/plasticity balance in adults.

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首次视觉体验后成年大鼠视觉通路的广泛地形重映射和功能锐化。
了解成年期稳定性/可塑性平衡的动态对于学习、疾病和从损伤中恢复至关重要。然而,感觉重映射的全脑地形图仍然未知。在这里,我们使用第一种在啮齿类动物磁共振成像(MRI)扫描仪中提供模式化视觉刺激的装置,结合生物学启发的计算模型,无创地绘制了全脑特性感受野(RF)和空间频率(SF)调谐曲线,这些曲线目前只能从侵入性电生理学或光学成像中获得。然后,我们追踪了可塑性慢性视觉剥夺模型(VDM)中的RF动力学,发现光照逐渐促进了成年大鼠的大规模地形重映射。在光照下,最初未专门化的视觉通路逐渐证明RF变尖(更小且更具空间选择性)和SF调谐曲线增强。我们的研究结果表明,VDM后的视觉体验重塑了视觉系统的结构和功能,并改变了成年人的稳定性/可塑性平衡。
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来源期刊
PLoS Biology
PLoS Biology 生物-生化与分子生物学
CiteScore
14.40
自引率
2.00%
发文量
359
审稿时长
3 months
期刊介绍: PLOS Biology is an open-access, peer-reviewed general biology journal published by PLOS, a nonprofit organization of scientists and physicians dedicated to making the world's scientific and medical literature freely accessible. The journal publishes new articles online weekly, with issues compiled and published monthly. ISSN Numbers: eISSN: 1545-7885 ISSN: 1544-9173
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