Weight loss to disrupt type 2 diabetes.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Diabetology International Pub Date : 2023-04-04 eCollection Date: 2023-07-01 DOI:10.1007/s13340-023-00626-0
Moath S Alsaqaaby, Carel W le Roux
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Abstract

Obesity is now recognised as a disease associated with significant morbidity and mortality. One of the most common metabolic complications of obesity is type 2 diabetes, because the two disease share similar pathophysiology. Weight loss is known to ameliorate the metabolic abnormalities underlying type 2 diabetes and improve glycemic control. A 15% or greater total body weight loss (TBWL) in patients with type 2 diabetes will have a disease-modifying effect, a result that is incomparable with other hypoglycemic-lowering interventions. Moreover, in patients with diabetes and obesity, weight loss exerts benefits beyond glycemic control and improves cardiometabolic disease risk factors and well-being. We review evidence supporting the role of intentional weight loss in managing type 2 diabetes. We suggest that many people with type 2 diabetes would benefit from an additional weight-based approach to managing their diabetes. Therefore, we proposed a weight-based treatment goal for patients with type 2 diabetes and obesity.

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减肥可以破坏2型糖尿病。
肥胖现在被认为是一种与严重的发病率和死亡率相关的疾病。肥胖最常见的代谢并发症之一是2型糖尿病,因为这两种疾病的病理生理学相似。众所周知,减肥可以改善2型糖尿病的代谢异常,改善血糖控制。2型糖尿病患者的总体重减轻15%或以上将具有改善疾病的效果,这是其他降血糖干预措施无法比拟的。此外,在糖尿病和肥胖患者中,减肥带来的好处超出了血糖控制,并改善了心脏代谢疾病的风险因素和健康状况。我们回顾了支持有意减肥在治疗2型糖尿病中的作用的证据。我们建议,许多2型糖尿病患者将受益于额外的基于体重的糖尿病管理方法。因此,我们为2型糖尿病和肥胖症患者提出了一个基于体重的治疗目标。
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来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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