Prognostic factors for hospitalization for severe hypoglycemia without diabetes mellitus: a retrospective study.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Diabetology International Pub Date : 2024-09-30 eCollection Date: 2024-10-01 DOI:10.1007/s13340-024-00757-y
Taito Miyoshi, Tetsuya Yamada, Kazuki Ota
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Abstract

Patients with non-diabetic hypoglycemia have a poorer prognosis than those with diabetic hypoglycemia. However, the factors associated with prognosis remain unclear. Therefore, this study aimed to identify the prognostic factors for non-diabetic hypoglycemia. This is a retrospective study of patients hospitalized for severe hypoglycemia with blood glucose ≤ 3.0 mmol/L (54 mg/dL) due to non-diabetic hypoglycemia between April 2008 and June 2023. Additionally, the underlying cause of hypoglycemia was identified, and the factors associated with mortality were examined. Of the 134 hospitalized patients, 126 were analyzed, excluding cases of multiple or scheduled hospitalizations. The most common causes of hypoglycemia were malnutrition (n = 79, 62.7%), alcohol intake (n = 27, 21.4%), and hypothermia (n = 27, 21.4%); 76 (60.3%) patients had multiple associated factors. Of the 126 patients, 52 died within 90 days. In the multivariate analysis, the estimated glomerular filtration rate (eGFR) (< 30 mL/min/1.73 m2) was independently associated with death [odds ratio (OR) 5.78, 95% confidence interval (CI) 1.69-19.8], whereas blood glucose (OR 0.95, 95% CI 0.92-0.99), serum albumin (OR 0.27, 95% CI 0.12-0.59), and alcohol intake (OR 0.03, 95% CI 0.004-0.34) were associated with survival. Moreover, age (OR 1.0, 95% CI 0.97-1.04) was not associated with death. Patients with non-diabetic hypoglycemia had a very high mortality. Low eGFR, blood glucose levels, and serum albumin levels at admission were associated with 90-day mortality, and alcohol intake was associated with survival.

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无糖尿病的严重低血糖住院预后因素:一项回顾性研究。
与糖尿病低血糖患者相比,非糖尿病低血糖患者的预后较差。然而,与预后相关的因素仍不清楚。因此,本研究旨在确定非糖尿病低血糖症的预后因素。这是一项回顾性研究,研究对象是2008年4月至2023年6月期间因血糖≤3.0 mmol/L(54 mg/dL)的非糖尿病性低血糖而住院治疗的严重低血糖患者。此外,还确定了低血糖症的根本原因,并研究了与死亡率相关的因素。对 134 名住院患者中的 126 人进行了分析,其中不包括多次住院或计划住院的病例。最常见的低血糖原因是营养不良(79 例,62.7%)、酒精摄入(27 例,21.4%)和体温过低(27 例,21.4%);76 例(60.3%)患者有多种相关因素。在 126 名患者中,52 人在 90 天内死亡。在多变量分析中,估计肾小球滤过率(eGFR)(2) 与死亡独立相关[几率比(OR)5.78,95% 置信区间(CI)1.69-19.8],而血糖(OR 0.95,95% CI 0.92-0.99)、血清白蛋白(OR 0.27,95% CI 0.12-0.59)和酒精摄入量(OR 0.03,95% CI 0.004-0.34)与存活率相关。此外,年龄(OR 1.0,95% CI 0.97-1.04)与死亡无关。非糖尿病低血糖患者的死亡率非常高。入院时的低 eGFR、血糖水平和血清白蛋白水平与 90 天死亡率有关,酒精摄入量与存活率有关。
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来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
期刊最新文献
General aspects of genetic studies on diabetes mellitus. Causes of death in Japanese patients with diabetes based on the results of survey of 68,555 cases during 2011-2020: committee report on causes of death in diabetes mellitus, Japan Diabetes Society (English version). Prognostic factors for hospitalization for severe hypoglycemia without diabetes mellitus: a retrospective study. Two cases of conventional fulminant type 1 diabetes: following the depletion process of endogenous insulin secretion and literature review. Calculated estimation of the metabolic clearance rate of insulin measured by glucose clamp examination in out-patient clinical practice.
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