Lactose Intolerance - Single Nucleotide Polymorphisms and Treatment.

IF 6.8 4区 医学 Q1 NUTRITION & DIETETICS Journal of the American Nutrition Association Pub Date : 2024-02-01 Epub Date: 2023-08-28 DOI:10.1080/27697061.2023.2251557
Zlatina Chengolova, Radina Ivanova, Katya Gabrovska
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Abstract

The majority (about 70%) of the world's population suffers from lactose intolerance. Lactose intolerance leads to long-term discomfort when consuming milk and dairy products, and hence, to their avoidance. Consequently, the intake of important nutrients is reduced, which potentially has a negative impact on the overall health. Knowing the condition - lactose intolerance - will prevent people from unnecessarily restricting dairy products in their diets. In this study, lactose synthesis and catabolism in the human body are presented, also the types of lactose intolerance, as well as the methods of diagnosing this condition, are discussed. Special attention is paid to the genetic causes of this discomfort and to the tests that can be performed. Solutions for the treatment of lactose intolerance have also been proposed, both up-to-date and easily applicable, as well as future developments.

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乳糖不耐症--单核苷酸多态性与治疗。
世界上大多数人(约 70%)都患有乳糖不耐症。乳糖不耐症会导致人们在食用牛奶和乳制品时长期感到不适,从而避免食用。因此,重要营养素的摄入量会减少,这可能会对整体健康产生负面影响。了解乳糖不耐受症这一病症,可以避免人们在饮食中不必要地限制乳制品的摄入。本研究介绍了乳糖在人体内的合成和分解,还讨论了乳糖不耐受症的类型以及诊断方法。特别关注这种不适的遗传原因和可以进行的测试。此外,还提出了治疗乳糖不耐受症的最新和易于应用的解决方案,以及未来的发展方向。
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