LC-HRMS analysis of 13 classes of pharmaceutical substances in food supplements.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED Food additives & contaminants. Part B, Surveillance Pub Date : 2023-09-01 DOI:10.1080/19393210.2023.2214883

Luigi Giannetti, Valentina Gallo, Francesco Necci, Francesca Marini, Andrea Giorgi, Elisa Sonego, Francesca D'Onofrio, Bruno Neri

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引用次数: 1

Abstract

Food supplements should not contain substances considered unsafe or pose a health risk to consumers. In recent years illegal adulterants have been found in various functional foods without notification of their presence or amount in the labelling. In this study, a validated method was developed and applied as a screening method to detect 124 forbidden substances belonging to 13 classes of compounds in food supplements. Liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) and a simple and rapid extraction protocol was applied to 110 food supplements collected from the internet market or during official controls in Italy. The percentage of non-compliant samples was 4.5%, relatively high compared with the official control results for these substances usually obtained on other food matrices. The results suggested the need to strengthen controls in this field to detect food supplement adulteration, which represents a potential health risk for the consumer.

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食品补充剂中13类原料药的LC-HRMS分析。

食品补充剂不应含有被认为不安全或对消费者构成健康风险的物质。近年来，在各种功能食品中发现了非法掺假物质，但没有在标签上标明其存在或含量。本研究开发了一种有效的方法，并将其作为一种筛选方法，用于检测食品补充剂中13类化合物中的124种禁用物质。采用液相色谱-高分辨率质谱联用(LC-HRMS)和一种简单快速的提取方案，对从意大利网络市场或官方管制期间收集的110种食品补充剂进行了分析。不合格样品的比例为4.5%，与通常在其他食品基质上获得的这些物质的官方对照结果相比，相对较高。结果表明，有必要加强对这一领域的控制，以检测食品添加剂掺假，这对消费者构成潜在的健康风险。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.

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