Fronto-parietal white matter microstructure associated with working memory performance in children with ADHD

IF 3.2 2区心理学 Q1 BEHAVIORAL SCIENCES Cortex Pub Date : 2023-09-01 DOI:10.1016/j.cortex.2023.03.015

Lillian M. Dipnall , Danah Hourani , Simone Darling , Vicki Anderson , Emma Sciberras , Timothy J. Silk

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Abstract

Introduction

Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with many functional impairments thought to be underpinned by difficulties in executive function domains such as working memory. The superior longitudinal fasciculus (SLF) plays an integral role in the development of working memory in neurotypical children. Neuroimaging research suggests reduced white matter organization of the SLF may contribute to working memory difficulties commonly seen in ADHD. This study aimed to examine the relationship between white matter organization of the SLF and working memory in children with ADHD.

Methods

We examined the association of tract volume and apparent fibre density (AFD) of the SLF with working memory in children with ADHD (n = 64) and controls (n = 58) aged 9–11years. Children completed a computerized spatial n-back task and underwent diffusion magnetic resonance imaging (dMRI). Constrained spherical deconvolution-based tractography was used to construct the three branches of the SLF bilaterally and examine volume and AFD of the SLF.

Results

Regression analyses revealed children with ADHD exhibited poorer working memory, and lower volume and AFD of the left SLF-II compared to healthy controls. There was also an association between reaction time and variability (RT and RT-V) and the left SLF-II. Further analyses revealed volume of the left SLF-II mediated the relationship between ADHD and working memory performance (RT and RT-V).

Discussion

These findings add to the current body of ADHD literature, revealing the potential role of frontoparietal white matter in working memory difficulties in ADHD.

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多动症儿童工作记忆表现与额顶叶白质微观结构的关系

引言注意力缺陷/多动障碍（ADHD）是一种神经发育障碍，有许多功能损伤，被认为是由工作记忆等执行功能领域的困难所支撑的。上纵束（SLF）在神经正常儿童工作记忆的发展中起着不可或缺的作用。神经影像学研究表明，SLF白质组织的减少可能导致多动症中常见的工作记忆困难。本研究旨在探讨多动症儿童SLF的白质组织和工作记忆之间的关系。方法在9–11岁的ADHD儿童（n=64）和对照组（n=58）中，我们研究了SLF的束体积和表观纤维密度（AFD）与工作记忆的关系。儿童完成了一项计算机化的空间n背任务，并接受了扩散磁共振成像（dMRI）。使用基于约束球面反褶积的束描记术构建双侧SLF的三个分支，并检查SLF的体积和AFD。结果回归分析显示，与健康对照组相比，ADHD儿童的工作记忆较差，左侧SLF-II的体积和AFD较低。反应时间和变异性（RT和RT-V）以及左侧SLF-II之间也存在关联。进一步的分析显示，左侧SLF-II的体积介导了多动症和工作记忆表现（RT和RT-V）之间的关系。讨论这些发现增加了ADHD的现有文献，揭示了额顶白质在ADHD工作记忆困难中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cortex 医学-行为科学

CiteScore

7.00

自引率

5.60%

发文量

250

审稿时长

74 days

期刊介绍： CORTEX is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi.