Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Current Osteoporosis Reports Pub Date : 2023-04-01 DOI:10.1007/s11914-023-00783-w

Arianna Ericka Gómez, Sumaya Addish, Kurtis Alvarado, Priscilla Boatemaa, Anne C Onyali, Emily G Ramirez, Maria F Rojas, Jyoti Rai, Kiana A Reynolds, W Joyce Tang, Ronald Young Kwon

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Abstract

Purpose of review: Chromosome region 7q31.31, also known as the CPED1-WNT16 locus, is robustly associated with BMD and fracture risk. The aim of the review is to highlight experimental studies examining the function of genes at the CPED1-WNT16 locus.

Recent findings: Genes that reside at the CPED1-WNT16 locus include WNT16, FAM3C, ING3, CPED1, and TSPAN12. Experimental studies in mice strongly support the notion that Wnt16 is necessary for bone mass and strength. In addition, roles for Fam3c and Ing3 in regulating bone morphology in vivo and/or osteoblast differentiation in vitro have been identified. Finally, a role for wnt16 in dually influencing bone and muscle morphogenesis in zebrafish has recently been discovered, which has brought forth new questions related to whether the influence of WNT16 in muscle may conspire with its influence in bone to alter BMD and fracture risk.

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多种机制解释CPED1-WNT16骨密度位点的遗传效应。

回顾目的:染色体区域7q31.31，也被称为CPED1-WNT16位点，与骨密度和骨折风险密切相关。本综述的目的是重点介绍CPED1-WNT16位点基因功能的实验研究。最近发现:位于CPED1-WNT16位点的基因包括WNT16、FAM3C、ING3、CPED1和TSPAN12。小鼠实验研究强烈支持Wnt16对骨量和强度是必要的这一观点。此外，Fam3c和Ing3在体内调节骨形态和/或体外成骨细胞分化中的作用已被确定。最后，最近发现wnt16在斑马鱼骨和肌肉形态发生中的双重作用，这就提出了新的问题，即wnt16对肌肉的影响是否可能与对骨骼的影响共同改变骨密度和骨折风险。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.